Because of its antitumor therapeutic-activity,as well as its application in food industries to improve the quality,L-asparaginase has attracted considerable attention from several investigators.In recent years,fungi h...Because of its antitumor therapeutic-activity,as well as its application in food industries to improve the quality,L-asparaginase has attracted considerable attention from several investigators.In recent years,fungi have occupied advanced rank among microorganisms in the production process of the enzyme.This review is spotting the light on the advantages of fungal enzyme and its applications in the food industry and medications.The solid-state fermentation was discussed as the wide alternative and most accepted biosynthesis technique.However,some lights were also spotted to the statistical experimental design of the fermentation process,mainly on the methodology of the response surface for L-asparaginase biosynthesis by fungi.Finally,the immobilization of the enzyme and the features of the widely used solid substrates for the maximization of the production process were explored.展开更多
基金the Deanship of Scientific Research at King Khalid University,Abha,KSA for funding this work under Grant number(G.R.P/150/40).
文摘Because of its antitumor therapeutic-activity,as well as its application in food industries to improve the quality,L-asparaginase has attracted considerable attention from several investigators.In recent years,fungi have occupied advanced rank among microorganisms in the production process of the enzyme.This review is spotting the light on the advantages of fungal enzyme and its applications in the food industry and medications.The solid-state fermentation was discussed as the wide alternative and most accepted biosynthesis technique.However,some lights were also spotted to the statistical experimental design of the fermentation process,mainly on the methodology of the response surface for L-asparaginase biosynthesis by fungi.Finally,the immobilization of the enzyme and the features of the widely used solid substrates for the maximization of the production process were explored.
