Newly identified genetic variant rs2294693 in UNC5CL gene is associated with decreased risk of esophageal carcinoma in the J&K Population–India

Esophageal cancer is the second most common type of cancer after lung carcinoma in the state of Jammu and Kashmir(J&K).The understanding of genetics in Esophageal cancer development is poor in the state.Genome wide association studies(GWAS)has proved to be unsurpassed tool in identification of new loci associated with different cancers.GWAS in Chinese population has identified SNP rs2294693 present in UNC5CL(UNC-5 Family C-Terminal like)to be associated with non-cardia gastric cancer.We performed a case control association study and genotyped the SNP rs2294693 using Taqman allele discrimination assay in 566 individuals(166 esophageal cancer patients and 400 controls)belonging to the J&K population.A statistically significant protective association with allelic odds ratio of 0.73(0.56–0.94 at 95%CI)and p value=0.016 was observed.This is the first study in relation to esophageal cancer in the Jammu and Kashmir population,so far it has been studied in association with gastric carcinoma in the Chinese population only.The results indicate that the polymorphism rs2294693 is associated with esophageal cancer susceptibility and the mutant(T)allele might be a protective factor for esophageal cancer among Jammu and Kashmir population.Further the functional characterization of the variation is also warranted.

任何事物都可以基于IP之上

从VoIP技术的流行至今,整个基于IP的商业通讯经历了巨大的变化。这篇文章着眼于运行于IP之上的各种应用技术,如移动电视、远程呈现、手机视频会议、基于IP的气味合成、Teredo隧道。众所周知,IP技术的出现是如何改变了我们的沟通方式。在单纯的数据传输之后,也许就是VoIP的天下了。时下VoIP已经成为我们生活中不可缺少的一部分,甚至在我们都还没有了解它之前,这项技术就让我们如此的着迷了。而眼前最时尚的事或许就是基于IP之上的视频服务了,它如同手机视频一样,受到了广泛的关注。在这篇文章中,我们将重点关注那些建筑于IP之上的通讯热点潮流和最新的一些研发成果,向您阐释基于IP的林林总总。