Peraluminous A-type granites formed through synchronous fractionation,magma mixing,mingling,and undercooling:evidence from microgranular enclaves and host Mesoproterozoic Kanigiri granite pluton,Nellore Schist Belt,southeast India

The field and microstructural features coupled with mineral chemical data from microgranular enclave(ME)and host Mesoproterozoic Kanigiri granite(KG)pluton of Nellore Schist Belt(NSB),Southeastern India,have been documented in order to infer the likely processes responsible for the origin and evolution of ME and host KG magma.The ME and host KG bear the same mineral assemblages barring the KG which does not contain amphibole;however,they are modally disequilibrated.The ME in KG is originated due to multiple intrusions of ME magmas into the crystallizing host KG magma chamber.Field and textural features indicate the dynamic magma flow,mingling,and undercooling of the ME against a relatively cooler surface of host KG magma.The presence of NSB country rock xenoliths and its diffuse boundaries suggest the intrusive relation and marginal assimilation by the intruding KG magma.The occasional cumulate texture in the ME appears to have formed by the accumulation of early-formed minerals that crystallized rapidly in the ME magma globules.The ME shows the magmatically deform features developed due to the flowage and erosion by the subsequent intrusions of ME magma pulses into the crystallizing host KG magma chamber.The ME amphiboles show unusual composition as ferro-edenitic hornblende to potassian-hastingsitic hornblende,that crystallized in the subalkaline-alkaline transition,low fO_(2)(reducing to mildly oxidizing)magma.The unusual extremely low Mg/Mg+Fe^(t)=0.015(avg.)of ME amphiboles may be related to the changing physico-chemical(P,T,fO_(2),and H_(2)O)condition of the ME magma or they might have crystallized in equilibrium with more evolved KG magma.The KG(FeOt/MgO=37.04,avg.)and ME(FeO~t/MgO=77.72,avg.)biotites are siderophyllite,and buffered between QFM and NNO syn-crystallizing in the water undersaturated(H_(2O)≈3.58 wt.%in KG;≈3.53wt.%in ME),alkaline anorogenic(A-type)host magmas that were emplaced at mid-crustal(4–5 kbar;17 km)depth.Field,microtextural and mineral chemical evidences suggest that the alkaline KG magma originated from crustal source and evolved through synchronous fractionation,mixing,and mingling with coeval ME magmas in the KG magma chamber.

Impact of COVID-19 Pandemic on Mental Health of Healthcare Workers–A Perception of Indian Hospital Administrators

Since the coronavirus pandemic,many factors led to the change in the mental well-being of hospital administrators and their staff.The pandemic negatively impacted the availability and capability of health professionals to deliver essential services and meet rising demand.Therefore,this study aimed to understand the perspective of hospital administrators about issues and challenges that negatively impacted their staff’s mental health and hospital administrators’coping response to mitigate those challenges and issues.An exploratory qualitative study was conducted with 17 hospital administrators(superintendents,deputy superintendents,nursing in charge and hospital in charge)working in a government district hospital of Rajasthan state during September 2022 and October 2022.This study revealed various emerging themes on mental health-related issues,challenges and coping strategies reported by the administrators.Themes and sub-themes that emerged from this study were 1)Perceived mental health of HCWs-perceived importance of mental health,2)Impact of COVID-19 on the mental health of HCWs–common mental health issues,changes in mental health pre and post-pandemic,3)Impact of COVID-19 on health behavior of HCWs-increased self-care and awareness,4)Challenges responsible for poor mental health of HCWs-organizational,ethical and societal challenges and 5)Strategies to retain mental health of HCWs-effective coping strategies.The most common problems were increased levels of stress,feeling fatigued,tiredness,weak and anxiety among the HCWs.Keeping their staff motivated was the biggest challenge reported.Social support,counseling through professionals and demystifying myths were the most effective coping strategies adopted by the participants.In conclusion,this study reported poor mental health-related issues,challenges faced by the HCWs and effective strategies adopted by hospital administrators during tough situations.This study will assist hospital administrators in developing interventions such as regular training programs and workshops to teach effective coping skills to address poor mental health during crises.

Emerging leishmaniasis in southern Himalayas:A mini-review

Leishmaniasis is a vector-borne parasitic disease affecting millions of people worldwide.However,in the last decade,the number of cases has been reduced from well-documented endemic parts,but sporadic cases have been reported widely from various non-endemic areas,especially from the southern Himalayan zone.This raises concerns about the emergence of new ecological niches.This warrants a critical evaluation of key factors causing this rapid spread and possibly indigenous transmission.This mini-review article is aimed to briefly address the parasite,the vector,and the environmental aspects in the transmission of leishmaniasis in these new foci against a background of worldwide endemic leishmaniasis with a special focus on the southern Himalayan zone.As the lack of knowledge about the causative parasites,vectors,reservoir hosts,atypical presentations,and their management make the problem serious and may lead to the emergence of public health issues.The present works also reviewed the existing information regarding clinical variations,diagnostic methods,treatment,its outcome,and ignite for further research in these aspects of the disease.

白内障合并翼状胬肉患者行联合手术后的疗效观察

目的:观察白内障合并翼状胬肉患者行联合手术后的疗效。方法:对22例(平均年龄:59.05±8.70岁)并发白内障和翼状胬肉(长度2-5mm)患者进行前瞻性单中心研究,随访时间为3mo~1a。测定术前和术后3mo的平均角膜曲率(Kmean)、平均散光和最佳矫正视力(LogMAR)。观察术前角膜曲率和翼状胬肉大小与预测误差的关系。结果:共18例(81.8%)患者PE<±0.50D,4例(18.2%)患者PE为±0.50D~±1.00D,没有PE>1.00D的患者。手术前后眼轴长度无差异(P=0.77)。Kmean从术前42.994±1.536增加到术后43.324±1.479(P=0.105)。术后角膜散光由术前2.09±0.789D降至术后0.523±0.277D(P<0.05)。BCVA(LogMAR)从术前1.007±0.402显著提高到术后0.024±0.062(P<0.05)。角膜曲率变化与预测误差无相关性(r=-0.29,P=0.19)。翼状胬肉大小与预测误差无相关性(r=0.2997,P=0.17)。结论:超声乳化与折叠式人工晶状体植入联合自体结膜移植术的应用是一种安全有效的手术方法。

An Integrated Approach to Comprehend MYMIV-Susceptibility of Blackgram Cv. T9 Possessing Allele of CYR1, the Cognate R-Gene

Blackgram, an important legume crop, faces the constraint of Mungbean yellow mosaic India virus (MYMIV)-stress resulting in severe crop penalty. MYMIV-resistant plants exhibit incompatible response via a cognate CYR1 gene-mediated interaction with virus effector molecule. In this study, we searched for the susceptible allele of the “R” gene in Cv. T9. Southern hybridization study confirmed presence of an allele in Cv. T9. However, transcripts of the CYR1 could not be detected either by RT-PCR or by Northern hybridization in Cv. T9 and also in other susceptible blackgram line. The allele was isolated, sequenced and referred as cyr1. In silico study revealed that cyr1 also encodes a CC-NBS-LRR protein like CYR1. However the CC domain of cyr1 is truncated by 128 amino acid residues indicating functional impairment with respect to the signal transduction after pathogen invasion. Comparative 3D structural modeling, hydrogen bonding and Van der Waals interaction studies revealed differences between CYR1 and cyr1. Lys519 and Thr490 present in the largest pockets of the CYR1 are the key interacting hotspots between CYR1 and MYMIV coat protein (CP). The weak Van der Waals interactions and intermolecular hydrogen bonding between cyr1 and CP confers less stability to the molecular recognition complex, unlike CYR1. Thus, the present investigation revealed Cv. T9 shows compatible interaction with MYMIV due to the truncation in the cyr1 sequence and consequent structural difference in the N-terminal of CC-domain.

Interdependence of Software and Progress of Mathematics in OR: Some Illustrative Cases and Challenges

This paper points out that delayed or no supply of software can kill potential benefits associated with new mathematical ideas that have led to development of new mathematics in OR. It also points out that it is a self-created situation by the scientific community. This situation needs attention and should be resolved urgently. Many illustrative examples have been given to justify the claim.

Equilibrium Positions of a Cable-Connected Satellites System under Several Influences

The present paper deals with the study of equilibrium positions of the motion of a system of two artificial satellites connected by a light, flexible, inextensible and non-conducting cable under the influence of solar radiation pressure, earth’s oblateness, shadow of the earth and air resistance. Here, we study the case of circular orbit of the centre of mass of the system. We derive differential equations of motion of the system. General solutions of the differential equations are beyond the reach. On the other hand, the general solutions do not serve our purpose. Jacobian integral of the system has also been obtained. Thereafter equilibrium positions of the motion of the system have been obtained.

Recent advances on the association of apoptosis in chronic non healing diabetic wound

Generally, wounds are of two categories, such as chronic and acute. Chronic wounds takes time to heal when compared to the acute wounds. Chronic wounds include vasculitis, non healing ulcer, pyoderma gangrenosum, and diseases that cause ischemia. Chronic wounds are rapidly increasing among the elderly population with dysfunctional valves in their lower extremity deep veins, ulcer, neuropathic foot and pressure ulcers. The process of the healing of wounds has several steps with the involvement of immune cells and several other cell types. There are many evidences supporting the hypothesis that apoptosis of immune cells is involved in the wound healing process by ending inflammatory condition. It is also involved in the resolution of various phases of tissue repair. During final steps of wound healing most of the endothelial cells, macrophagesand myofibroblasts undergo apoptosis or exit from the wound, leaving a mass that contains few cells and consists mostly of collagen and other extracellular matrix proteins to provide strength to the healing tissue. This review discusses the various phases of wound healing both in the chronic and acute wounds especially during diabetes mellitus and thus support the hypothesis that the oxidative stress, apoptosis, connexins and other molecules involved in the regulation of chronic wound healing in diabetes mellitus and gives proper understanding of the mechanisms controlling apoptosis and tissue repair during diabetes and may eventually develop therapeutic modalities to fasten the healing process in diabetic patients.

Introduction to magnesium alloy processing technology and development of low-cost stir casting process for magnesium alloy and its composites

This paper presents the processing of magnesium alloys and its composite through different stir casting technologies.Design and devel-opment of stir casting technology that is suitable for processing of magnesium alloys has been done in this study.The low-cost stir casting processing of magnesium alloy and its composite with flux and without flux has been explained.The magnesium alloy and its composite have been fabricated by both the stir casting process.The micro structural characterization and mechanical properties of the developed composites has been evaluated.The optical emission spectroscopy of the developed alloy and factography of the developed alloy as well as composite was also examined.

A phase II study of neoadjuvant chemotherapy followed by organ preservation in patients with muscle-invasive bladder cancer

Objective:Conservative approaches in muscle-invasive bladder cancer(MIBC)have been evolved to avoid aggressive surgery,but are limited to elderly,frail,and patients medically unfit for surgery.Our study aimed to assess the response rate of neoadjuvant chemotherapy(NACT)before radiotherapy(RT)in MIBC patients.Methods:Forty patients with urothelial carcinoma of stage T2-T4a,N0,M0 were enrolled between November 2013 and November 2015,and treated with three cycles of NACT with gemcitabine-cisplatin.Post-NACT response was assessed using Response Evaluation Criteria in Solid Tumors(RECIST)criteria.Patients who achieved complete response(CR)and partial response(PR)>50%were treated with radical RT,and those who had PR<50%,stable disease(SD),and progressive disease(PD)underwent radical cystectomy(RC).Survival analysis was done with Kaplan-Meier method and point-to-time events were analyzed with Cox-proportional hazards regression model.Results:After NACT,35(87.5%)patients achieved either PR>50%or CR,and were treated with RT.Five(12.5%)patients who had PR<50%,SD,or PD underwent RC.All patients who received radiation showed CR after 6 weeks.Median follow-up was 43 months(range:10-66 months)and median overall survival(OS)was not reached.Three-year OS,local control,and disease-free survival were 70.1%,60.9%,50.6%,respectively,and 50%of patients preserved their functioning bladder.Three-year OS rate was 88.9%in patients who achieved CR to NACT,73.1%in patients with PR≥50%and 40%in patients with PR<50%.Conclusion:NACT followed by RT provides a high probability of local response with bladder preservation in CR patients.Appropriate use of this treatment regimen in carefully selected patients may omit the need for morbid surgery.

Inhibition of extracellular vesicle pathway using neutral sphingomyelinase inhibitors as a neuroprotective treatment for brain injury

Traumatic brain injury is a sudden trauma or blow on the head,and severe traumatic brain injury is a major cause of death and disability worldwide.The acute and chronic consequences following traumatic brain injury can lead to progressive secondary neurodegenerative changes and cognitive dysfunction.To date,there is no effective pharmaceutical products for the treatment to reduce secondary damage after brain injury.The discovery of extracellular vesicles has attracted considerable scientific attention due to their role in cell-to-cell communication.Extracellular vesicles have shown their potential to carry not only biological molecules but also as a drug delivery vehicle.As a carrier of molecular information,extracellular vesicles have been involved in physiological functions as well as in the modulation of immune responses.Here,we aim to provide new insights into the contrasting role of extracellular vesicles in the propagation of inflammatory responses after brain injury.As a carrier of pro-inflammatory molecules,their role as functional mediators in the pathophysiology of brain injury is discussed,addressing the inhibition of the extracellular vesicle pathway as an anti-inflammatory or neuroprotective approach to improve the outcome of both acute and chronic inflammation following brain injury.Here,we summarize therapeutic strategies to diminish the risk the neurodegeneration post brain injury and propose that neutral sphingomyelinase inhibitors could be used as potentially useful therapeutic agents for the treatment of brain injury associated neuroinflammation.

Mineralogy, Geochemistry and Palaeomagnetism of Mafic Dykes from Kumaun Lesser Himalaya: Implication on Petrogenesis, Tectonic Setting and Timing of Mafic Magmatism in Northern Part of Indian Lithosphere

Occurrence of mafic dykes in Himalaya has been intriguing and debated since long because of its difficulty to ascent and emplacement through a thickened crust.Mafic dykes in Kumaun Lesser Himalaya(KLH)of central Indian

Influence of Rising Atmospheric CO₂Concentrations and Temperature on Morpho-Physiological Traits and Yield of Rice Genotypes in Sub Humid Climate of Eastern India

A possible scenario for the end of the 21st century is that the atmospheric CO2 concentration will be in the range of 510 - 760 μl&middot;L-I and that the mean global temperature will be 1.5&deg;C - 4.5&deg;C higher than present day. One of the pre-eminent manifestations of climate change is the increase in atmospheric CO2 concentration. Both CO2 and temperature are the key variables of global climate and may cause significant changes in crop productivity. An experiment was conducted inside open top chamber (OTCs) in kharif season 2014 to evaluate the effects of CO2 enrichment and temperature rise with condition OTC1 (ambient condition), OTC2 (25% higher CO2 than ambient), OTC3 (25% higher CO2 + 2&deg;C 】ambient temperature) and OTC4 (2&deg;C 】ambient temperature) on physiological traits and yield of rice genotypes to identify the suitable genotypes for changing climatic conditions. The study revealed that rice genotypes performed better under elevated CO2, with slight changes in development, such as growth and in yield attributing traits, depending on the genotypes. However, the beneficial direct impact of elevated (CO2) on crop yield can be counteract by elevated temperatures. Rice genotype IR83376-B-B-24-2 was highly responsive while IR84895-B-127-CRA-5-1-1 was least responsive toward elevated CO2. Physiological traits like relative water content (RWC %), membrane stability index (MSI %), chlorophyll content, photosynthetic rate and TSS content were improved under elevated CO2. However, responses of these traits were negative with elevated temperature. We point out that studies related to changes in crop physiology and yield as a consequence of global climatic changes should be a priority due to their association with food security.

Biometric Recognition for Pet Animal

Missing, swapping, false insurance claims and reallocation of pet animals (dog) are global problems throughout the world and research done to solve this problem is minimal. Traditional biometrics and non-biometrics methods have their own boundaries and they fail to provide competent level of security to pet animal (dog). The work on animal identification based on their phenotype appearance (coat patterns) has been an active research area in recent years and automatic face recognition for dog is not reported in the literature. Dog identification needs innovative research to protect the pet animal. Therefore it is imperative to initiate research, so that future face recognition algorithm will be able to solve this important problem for identification of pet animal (like dog, cat). In this paper an attempt has been made to minimize the above mentioned problems by biometrics face recognition of dog. The contributions of this research are: 1) implementation of an existing biometrics algorithm which mitigates the effects of covariates for dogs;2) proposed fusion based method for recognition of pet animal with 94.86% accuracy. Thus in this paper, we have tried to demonstrate that face recognition of dog can be used to recognize the dog efficiently.

Noninvasive method for determining blood pressure and contours of arterial and volume pulses

A noninvasive method for monitoring blood pressure, based on the principles established by Riva-Rocci and Korotkoff (K), is described;it furnishes, after a single compression-deflation cycle of the arm-encircling cuff, values of sys-tolic and diastolic blood pressures as well as the contours of the brachial arterial pulse and the corresponding volume pulse. K-sounds are detected by a single microphone situated in the cubital fossa, and the time-varying cuff pressure P(t) is read by a piezoresistive pressure sensor. The behavior of P(t) during deflation is resolved into two parts, P(t)=p(t)+b(t);p is a train of posi-tive going pulses (arising from arterial pulsa-tions), whereas b is a slowly changing baseline. Noise pulses in the microphone output are re-jected by using the observation that the first few K-sounds are emitted when p is close to a maxi-mum, and the last few when dp/dt is close to a maximum. The performance of the instrument is illustrated by showing how it copes with ambi-ent noise and involuntary manual perturbations of P, and by presenting contours of various pulses.

A New Heuristic for the Convex Quadratic Programming Problem

This paper presents a new heuristic to linearise the convex quadratic programming problem. The usual Karush-Kuhn-Tucker conditions are used but in this case a linear objective function is also formulated from the set of linear equations and complementarity slackness conditions. An unboundedness challenge arises in the proposed formulation and this challenge is alleviated by construction of an additional constraint. The formulated linear programming problem can be solved efficiently by the available simplex or interior point algorithms. There is no restricted base entry in this new formulation. Some computational experiments were carried out and results are provided.

Impact of Coupling and Cohesion in Object-Oriented Technology

The interaction between the classes or within the classes shows the complexity of the design. For one smaller problem, there may be more than one software design but who will be the best;depends on the complexity level of software design. Therefore, coupling and cohesion which shows the interlinking of classes and strength of classes;control the complexity of the design. The best software object oriented design is based upon the low coupling and high cohesion level. In the present work, a real case study of Life Insurance policy for handicapped person is demonstrated through the UML Class Diagram;coupling and cohesion levels are measured and results are demonstrated in the form of tables.

Defect induced room-temperature ferromagnetism and enhanced photocatalytic activity in Ni-doped ZnO synthesized by electrodeposition

Zn0.90Ni0.10O nanoparticles have been synthesized by single-bath two-electrode electrodeposition at constant voltage. X-ray diffraction, UV vis and photoluminescence studies reveal that a single-phase polycrystalline hcp wurtzite crystal structure of ZnO is evolved. The material consists of a large number of defects such as oxygen vacancy (Ov) and zinc interstitial (Zi). The magnetization study reveals that the sample exhibits room-temperature global ferromagnetism and the ferromagnetic ordering seems to be defect induced via bound magnetic polaron mechanism, and double exchange is also expected to have played role. Interesting optoelectronic properties have been found in the synthesized sample and the material seems to be a potential candidate to be used as a UV sensor. Such a transition metal doped ZnO based dilute magnetic semiconducting system exhibiting room-temperature ferromagnetism is likely to be first of its kind in the sense that such materials have not yet been reported to be synthesized by the simple method of electrodeposition to the best of our knowledge on the basis of ample literature review.

Conquering new battlegrounds:Successful management of isolated giant retrovesical hydatid cyst with robotic assistance

Hydatid disease(HD)is an accidental human parasitic infestation by cestodes and is most commonly caused by Echinococcus granulosus.Liver happens to be the most common site of involvement,although involvement of other organ symptoms is not uncommon.Involvement of the retrovesical pouch by hydatidosis is generally secondary in nature with an incidence of 0.1%-0.5%only.Primary retrovesical hydatid cyst(RVHC)is extremely rare with only few cases in existing literature.RVHC can present with a wide gamut of symptoms ranging from asymptomatic to obstructive uropathy.A 38-year-old male presented to us with complaints of lower urinary tract symptoms(LUTS)and was found to have an isolated primary retrovesical hydatid cyst on evaluation.The RVHC had compressed the right ureter leading to a grossly hydronephrotic non-functional right kidney.The patient was started on albendazole therapy and underwent robot assisted right nephroureterectomy and partial pericystectomy for the RVHC.The postoperative period was uneventful with resolution of symptoms.This report highlights the various clinical presentations of RVHC as well as the minimal invasive management of this rare entity.

Measuring Effectiveness of Health Program Intervention in the Field

Improving and sustaining successful public health interventions relies increasingly on the ability to identify the key components of an intervention that are effective, to identify for whom the intervention is effective, and to identify under what conditions the intervention is effective. Bayesian probability an “advanced” experimental design framework of methodology is used in the study to develop a systematic tool that can assist health care managers and field workers in measuring effectiveness of health program intervention and systematically assess the components of programs to be applied to design program improvements and to advocate for resources. The study focuses on essential management elements of the health system that must be in place to ensure the effectiveness of IMNCI intervention. Early experiences with IMNCI implemented led to greater awareness of the need to improve drug delivery, support for effective planning and management at all levels and address issues related to the organization of work at health facilities. The efficacy of IMNCI program from the experience of experts and specialists working in the state is 0.67 and probability of effective- ness of all management components in the study is 58%. Overall the standard assessment tool used predicts success of around 39% for the IMNCI intervention implemented in current situation in Rajasthan. Training management component carried the highest weight-age of 21% with 73% probability of being effective in the state. Human resource management has weight-age of 13% with 53% probability of being effective in current scenario. Monitoring and evaluation carried a weight-age of 11% with only 33% probability of being effective. Operational planning carried a weight-age of 9% with 100% probability of being effectively managed. Supply management carried a weight-age of 8% with zero probability of being effective in the current field scenario. In the study, each question that received low score identifies it as a likely obstacle to the success of the health program. The health program should improve all sub-components with low scores to increase the likelihood of meeting its objectives. Public health interventions tend to be complex, programmatic and context dependent. The evaluation of evidence must distinguish between the fidelity of the evaluation process in detecting the success or failure of the intervention, and relative success or failure of the intervention itself. We advocate management attributes incorporation into criteria for appraising evidence on public health interventions. This can strengthen the value of evidence and their potential contributions to the process of public health management and social development.