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Traditional Chinese Medicinal Syndromes and Treatment in Colorectal Cancer 被引量:17
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作者 shan deng Bing Hu Hong-Mei An 《Journal of Cancer Therapy》 2012年第6期888-897,共10页
Colorectal cancer remains the third most common malignancy worldwide. According to the principles of Traditional Chinese Medicine (TCM), colorectal cancer is related to spleen-deficiency, damp-heat, and toxicity accum... Colorectal cancer remains the third most common malignancy worldwide. According to the principles of Traditional Chinese Medicine (TCM), colorectal cancer is related to spleen-deficiency, damp-heat, and toxicity accumulation. Traditional Chinese medicine has been confirmed to effectively reduce toxic side effects and enhance curative effects of chemotherapy, palliate clinical syndrome, prevent recurrence and metastasis, improve quality of life and immune function, and prolong survival time in colorectal cancer. However, TCM theoretical and syndrome differentiation study has lagged far behind due to progression of therapy model in colorectal cancer. As a type of drug treatment, there are some common biological basis between chemotherapy, targeted therapy and anti-cancer herb therapy in colorectal cancer, such as apoptosis, cell senescence and autophagy. There are growing needs to explore the effect mechanism and compatibility of anti-cancer herbs, to further enhance the efficacy of TCM treatment in colorectal cancer. 展开更多
关键词 Colorectal Cancer Syndrome Differentiation TRADITIONAL CHINESE MEDICINAL Treatment ANTI-CANCER HERB
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In vivo protective effect of late embryogenesis abundant protein(ApSK3 dehydrin)on Agapanthus praecox to promote post-cryopreservation survival
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作者 TINGTING HUANG shan deng +1 位作者 JIANGYUAN SHENG DI ZHANG 《BIOCELL》 SCIE 2022年第11期2507-2515,共9页
Dehydrins(DHNs),as members of the late embryogenesis abundant protein family,play critical roles in the protection of seeds from dehydration and plant adaptation to multiple abiotic stresses.Vitrification is a basic m... Dehydrins(DHNs),as members of the late embryogenesis abundant protein family,play critical roles in the protection of seeds from dehydration and plant adaptation to multiple abiotic stresses.Vitrification is a basic method in plant cryopreservation and is characterized by forming a glassy state to prevent lethal ice crystals produced during cryogenic storage.In this study,ApSK3 type DHN was genetically transformed into embryogenic calluses(EC)of Agapanthus praecox by overexpression(OE)and RNA interference(RNAi)techniques to evaluate the in vivo protective effect of DHNs during cryopreservation.The cell viability showed a completely opposite trend in OE and RNAi cell lines,the cell relative death ratio was decreased by 20.0%in ApSK3-OE EC and significantly increased by 66.15%in ApSK3-RNAi cells after cryopreservation.Overexpression of ApSK3 increased the content of non-enzymatic antioxidants(AsA and GSH)and up-regulated the expression of CAT,SOD,POD,and GPX genes,while ApSK3-RNAi cells decreased antioxidant enzyme activities and FeSOD,POD,and APX genes expression during cryopreservation.These findings suggest that ApSK3 affects ROS metabolism through chelating metal ions(Cu^(2+)and Fe^(3+)),alleviates H_(2)O_(2)and OH·excessive generation,activates the antioxidant system,and improves cellular REDOX balance and membrane lipid peroxidation damage of plant cells during cryopreservation.DHNs can effectively improve cell stress tolerance and have great potential for in vivo or in vitro applications in plant cryopreservation. 展开更多
关键词 DEHYDRIN Embryogenic callus CRYOPRESERVATION RNAI Gene overexpression
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《宫腔镜下子宫肌瘤去除术管理规范》团体标准的解读
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作者 魏莉 张浩 +3 位作者 谭欣 邓姗 黄秀峰 冯力民 《中华腔镜外科杂志(电子版)》 2024年第4期199-204,共6页
宫腔镜手术是黏膜下肌瘤微创保守性的一线治疗方案,随着宫腔镜技术的推广普及、作为一种普遍开展的常见病手术类型,中国妇幼保健协会于2023年10月22日颁布了《宫腔镜下子宫肌瘤去除术管理规范》(T/CMCHA 002-2023)团体标准。旨在为宫腔... 宫腔镜手术是黏膜下肌瘤微创保守性的一线治疗方案,随着宫腔镜技术的推广普及、作为一种普遍开展的常见病手术类型,中国妇幼保健协会于2023年10月22日颁布了《宫腔镜下子宫肌瘤去除术管理规范》(T/CMCHA 002-2023)团体标准。旨在为宫腔镜下子宫肌瘤去除术的技术、管理、实施方面提供指导和支持。该标准对宫腔镜下子宫肌瘤去除术的医疗机构、团队人员、设备和环境提出了标准化要求。同时,该标准还规范了宫腔镜下子宫肌瘤去除术的临床技术标准,包括手术技术、培训制度、结果评价和质量控制管理等。本文对该团体标准中提出的要求与建议进行解读,以期为临床工作者更好地理解及应用标准、规范临床实践提供参考。 展开更多
关键词 子宫肌瘤 子宫黏膜下肌瘤 宫腔镜下子宫肌瘤去除术 团体标准 解读
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Efficacy of intrauterine balloon stent or oral estrogen on prevention of adhesion after transcervical resection of septum in septate uterus:Study protocol for a randomized controlled multicenter study in China
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作者 shan deng Zichen Zhao +9 位作者 Limin Feng Xiaowu Huang Sumin Wang Xiang Xue Lei Yan Baorong Ma Lijuan Hao Xueying Li Lihua Yang Lan Zhu 《Chinese Medical Journal》 SCIE CAS CSCD 2023年第24期3016-3018,共3页
To the Editor:The septate uterus is the most common uterine anomaly and is associated with an increased risk of adverse reproductive outcomes.Transcervical resection of septum(TCRS)is widely performed in patients with... To the Editor:The septate uterus is the most common uterine anomaly and is associated with an increased risk of adverse reproductive outcomes.Transcervical resection of septum(TCRS)is widely performed in patients with adverse reproductive outcomes.The incidence of de novo intrauterine adhesions(IUAs)after TCRS is approximately 5%to 25%.[1]Various anti-adhesion methods are widely used in the clinical management of patients with septate uteri,including intrauterine devices,Foley balloons,estrogen,antibiotics,and hyaluronic acid gel.However,insufficient evidence supports or opposes any of these methods(Level C),[2]lacking high-grade evidence. 展开更多
关键词 PREVENTION SEPTUM AFTER
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子宫内膜息肉临床诊疗路径 被引量:18
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作者 仝佳丽 冯力民 +13 位作者 薛凤霞 沈丹华 郝敏 郭瑞霞 黄秀峰 邓姗 徐大宝 宋建东 王刚 朱琳 陈玉清 冯云 郎景和 朱兰 《中华妇产科杂志》 CAS CSCD 北大核心 2022年第7期491-495,共5页
子宫内膜息肉是常见的子宫内膜良性病变之一,可发生于青春期后的任何年龄,患病率随年龄增加而增高,其常见症状为异常子宫出血、不孕,或无明显症状。本临床诊疗路径以循证医学证据为基础,以临床规范诊疗为目的,建立从子宫内膜息肉高危因... 子宫内膜息肉是常见的子宫内膜良性病变之一,可发生于青春期后的任何年龄,患病率随年龄增加而增高,其常见症状为异常子宫出血、不孕,或无明显症状。本临床诊疗路径以循证医学证据为基础,以临床规范诊疗为目的,建立从子宫内膜息肉高危因素的识别、临床诊断、病理分型到治疗再到患者的长期管理、宣教的诊疗流程路径,给予临床医师共识性的指导建议,旨在为广大妇产科医师提供子宫内膜息肉临床诊疗的可行性和规范性流程。 展开更多
关键词 子宫内膜息肉 妇产科医师 异常子宫出血 循证医学证据 常见症状 临床医师 诊疗路径 诊疗流程
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Anxiety symptoms in patients with Mayer-Rokitansky-Küster-Hauser syndrome:a cross-sectional study 被引量:7
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作者 Shuang Song Na Chen +4 位作者 Yan-Ping Duan Jia Kang shan deng Hong-Xin Pan Lan Zhu 《Chinese Medical Journal》 SCIE CAS CSCD 2020年第4期388-394,共7页
Background:As a congenital malformation that results in infertility and an inability to have vaginal intercourse,Mayer-Rokitansky-Küster-Hauser(MRKH)syndrome places a considerable psychological burden on patients... Background:As a congenital malformation that results in infertility and an inability to have vaginal intercourse,Mayer-Rokitansky-Küster-Hauser(MRKH)syndrome places a considerable psychological burden on patients,which results in anxiety symptoms.However,only single case studies or a few small to medium-sized cross-sectional studies were identified to focus on anxiety symptoms in MRKH patients.Thus,the aim of this study was to explore the status of anxiety symptoms and the related factors in patients with MRKH syndrome.Methods:This cross-sectional study involving 141 patients with MRKH syndrome and 178 healthy women was conducted from January 2018 to December 2018.All participants were required to complete a demographic questionnaire and the Generalized Anxiety Disorder 7-item scale(GAD-7),Patient Health Questionnaire-9,Eysenck Personality Questionnaire-Revised,Short Scale for Chinese,and Chinese Version of the Female Sexual Function Index.The main outcome was the anxiety symptoms measured by the GAD-7.Main outcome was compared between the MRKH syndrome group and the healthy control group.Then,we explored the related factors by comparing patients with and without anxiety symptoms.Results:Of the respondents,24.1%experienced moderate to severe anxiety symptoms.Patients with MRKH syndrome manifested more severe anxiety symptoms than healthy women.Negative self-evaluation of femininity(odds ratio[OR]2.706,95%confidence interval[CI]1.010-7.247),neurotic personality traits(OR 1.100,95%CI 1.029-1.175),and coexisting depressive symptoms(OR 4.422,95%CI 1.498-13.049)were more prevalent in anxious patients.Conclusion:The findings stress the importance of anxiety symptom screening in MRKH patients and identify patients at risk of anxiety symptoms,providing a possible basis for future intervention. 展开更多
关键词 MRKH SYNDROME ANXIETY RISK FACTORS
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Preoperative Evaluation for Complex Female Genital Tract Malformation Using Three?dimensional Printing Technology 被引量:2
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作者 Shu Wang shan deng +3 位作者 Lan Zhu Jing-Jing Lu Yue Wang Jing-He Lang 《Chinese Medical Journal》 SCIE CAS CSCD 2017年第19期2388-2390,共3页
A 33-year-old woman, gravida 1, para 0, came to the hospital with the chief complaint of severe dysmenorrhea and infertility. Her menstrual cycle was regular, bleeding moderately for 3–5 days with an interval of 30 d... A 33-year-old woman, gravida 1, para 0, came to the hospital with the chief complaint of severe dysmenorrhea and infertility. Her menstrual cycle was regular, bleeding moderately for 3–5 days with an interval of 30 days. She was diagnosed with ectopic pregnancy and received the left salpingectomy in September 2014. Intraoperative exploration showed a slightly enlarged retroverted uterus with a wide fundus and a normal right fallopian tube. As a further examination of infertility, hysterosalpingography was done in January 2016, which showed a unicornuate uterus (left) with an obstructed unilateral fallopian tube. She was referred to the Department of Obstetrics and Gynecology at Peking Union Medical College Hospital in February 2016. Her basic body temperature showed biphasic pattern. The sperm test of her husband was normal. Physical examination indicated two vaginal orifices in the vestibule, with a vertical septate lying in between. The left lateral vaginal lumen could be easily expanded and speculated, and a normal cervix was seen at its top. In contrast, the cervix was unable to be seen through the right lateral vaginal lumen, which was narrow and difficult to be exposed or inspected. Pelvic ultrasound scan showed that the uterus was 4.7 cm ×6.0 cm × 3.6 cm in size, along with the Y-shaped endometrium of 0.8 cm in thickness, and a normal echo in the muscular layer. No abnormalities were found at the bilateral adnexa areas or pelvic cavity. Besides, the bilateral renal areas and ureters were found normal in the ultrasound scan as well. 展开更多
关键词 Female Genital Tract Anomalies Preoperative Diagnosis Three-dimensional Printing
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Comparison and Error Analysis of Off-design and Design Models of Energy Hubs 被引量:1
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作者 J.H.Zheng Jun Huang +4 位作者 shan deng Q.H.Wu Mengshi Li Xiaoxin Zhou Zhaoxia Jing 《CSEE Journal of Power and Energy Systems》 SCIE CSCD 2019年第4期454-465,共12页
The accuracy of the simulation model has a pro-found impact on the optimal operation of the energy hubs(EHs).However,in many articles,the constant model of the efficiency of equipment is adopted to formulate the opera... The accuracy of the simulation model has a pro-found impact on the optimal operation of the energy hubs(EHs).However,in many articles,the constant model of the efficiency of equipment is adopted to formulate the operation system,which would probably lead to a simplification of the simulation models.But,EHs are typically operated under off-design condition due to the fluctuations in cooling,heating,electricity requirement.More-over,even though the off-design characteristics are considered,few studies have suggested comparing the differences between those two models by considering the operation cost.In order to assess the effect of the off-design characteristics of EH on the optimal operation accuracy in this paper,two test cases are performed on the fixed and variable load conditions,respectively.In addition,the individual effect of off-design characteristics of each equipment on the optimal operation cost of the EH is also investigated through four optimization runs.It is worth mentioning that the optimal operation problem of the EH considering the off-design characteristics and on-off status of the equipment is a mixed integer non-linear programming problem(MINLP).By testing the design and off-design models on the two cases,the results of simulation demonstrate that the optimal operation cost for the off-design model is larger than that for the design model.Nonetheless,in the aspect of the authenticity of the system operation strategy,the off-design model performs better than the design model.Furthermore,a larger relative error of the system operation cost between the two models can be observed when the EH is operated under a relatively lower load condition,revealing that the influence of off-design characteristic on the optimal operation of EHs is too significant to be neglected. 展开更多
关键词 Design energy hubs MINLP OFF-DESIGN optimal operation
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