●AIM:To assess effectivity and safety of trifocal intraocular lenses(IOLs)and capsular tension rings in treating cataract patients with axial high myopia.●METHODS:A prospective nonrandomized controlled clinical tria...●AIM:To assess effectivity and safety of trifocal intraocular lenses(IOLs)and capsular tension rings in treating cataract patients with axial high myopia.●METHODS:A prospective nonrandomized controlled clinical trial was conducted.Totally 98 eyes(74 patients)who underwent femtosecond laser-assisted cataract surgery(FLACS)with trifocal IOLs were enrolled in the study and followed up for 2y after surgery:46 eyes(33 patients)with capsular tension ring implantation in the long axial lengths(AL)group(26<AL<29 mm)and 52 eyes(41 patients)in the normal AL group(22<AL<24.5 mm).Postoperative outcomes about effectivity and safety,including the subjective and objective visual quality,and postoperative complications were assessed.●RESULTS:Uncorrected distance visual acuity at 5 m and uncorrected intermediate visual acuity at 60 and 80 cm in the long AL group were significantly worse than those in the normal AL group at 3mo postoperatively(P<0.05).The differences in reading speed,spectacle independence and potential visual complaints between the two groups were not statistically significant(P>0.05).The dysfunctional lens index and total modulation transfer function(MTF)average height were similar between the two groups.The postoperative internal coma aberrations in the axial high myopia eyes were significantly higher than that in the normal AL group(P<0.05).The total satisfaction score in the long AL group(91.32±2.76)was slightly higher than that in the normal AL group(90.36±3.47),but there was no difference(P=0.136).A statistically negative correlation was found between corrected distance visual acuity(CDVA)and dysfunctional lens index(r=-0.382,P=0.009),and between CDVA and the total MTF average height(r=-0.374,P=0.01).But there was no significant correlation between CDVA and total satisfaction score(r=0.059,P=0.696).Postoperative complications mainly presented as posterior capsular opacity(PCO),retinal detachment and cystoid macular edema.There was no difference in the incidence of fundus disease(6.5%vs 3.8%,P=0.663)or PCO(17.4%vs 7.7%,P=0.217)between the two groups at two years.●CONCLUSION:The utilization of trifocal IOL and capsular tension ring implantation is beneficial for cataract patients with axial high myopia undergoing FLACS.This approach not only ensures excellent subjective feelings and objective visual quality,but also does not increase the incidence of postoperative complications.展开更多
由于可再生能源发电系统固有的不确定性以及日益扩大的电网规模和区域内电站结构的复杂度对电力系统稳定运行造成影响。抽水蓄能电站作为一种调频资源,已成为区域电网负荷频率控制(load frequency control,LFC)的重要手段之一。由此,开...由于可再生能源发电系统固有的不确定性以及日益扩大的电网规模和区域内电站结构的复杂度对电力系统稳定运行造成影响。抽水蓄能电站作为一种调频资源,已成为区域电网负荷频率控制(load frequency control,LFC)的重要手段之一。由此,开展了抽水蓄能电站的区域LFC研究,搭建了考虑死区和发电速度约束等非线性因素下的两区域再热式汽轮机组LFC模型,设计了一个分数阶PID(fractional order PID,FOPID)控制器,利用改进Oustaloup算法实现分数阶微分算子的近似并与传统的PID控制器进行比较。仿真结果表明,文中提出的FOPID策略在控制含有非线性环节的系统时能达到更好的控制效果,表现出较强的鲁棒稳定性。对于抽水蓄能电站参与的负荷频率控制,能够缩短频率恢复时间,使二次调频的动态性能得到很大提升。展开更多
目的观察远隔缺血处理对缺血再灌注损伤所致认知障碍大鼠的神经保护作用及其作用机理。方法选用雄性SD大鼠,采用双侧颈动脉闭塞(bilateral common carotid arteries occlusion,BCCAO)方法建立脑缺血再灌注致血管性认知障碍(vascular cog...目的观察远隔缺血处理对缺血再灌注损伤所致认知障碍大鼠的神经保护作用及其作用机理。方法选用雄性SD大鼠,采用双侧颈动脉闭塞(bilateral common carotid arteries occlusion,BCCAO)方法建立脑缺血再灌注致血管性认知障碍(vascular cognitive impairment,VCI)动物模型,将大鼠随机分为假手术组、对照组(VCI组)及远隔缺血处理(remote ischemic conditioning,RIC)组(VCI+RIC组)。VCI建模成功24 h后对RIC组大鼠进行RIC连续干预21 d,RIC期满后对三组大鼠采用Morris水迷宫实验进行定位航行实验和空间探索实验,定位航行实验连续进行5 d,记录第1天、第3天、第5天检测大鼠逃避潜伏期,第6天检测平台停留时间和穿越平台次数以评估认知功能。实验完成后在各组大鼠中随机选择5只取脑进行HE染色,电镜下观察各组大鼠脑白质及海马病理改变和神经元凋亡情况。结果Morri s水迷宫实验结果显示第1天、第3天、第5天对照组及RI C组大鼠逃避潜伏期较假手术组均有延长(P<0.05)。除假手术组外,另外两组大鼠逃避潜伏期时长随着训练次数增加逐渐缩短。第1天、第3天两组间差异无统计学意义,第5天RIC组成绩好于对照组(P<0.05)。第6天空间探索实验中,目标象限停留时间假手术组与RIC组相近(47.2±10.2 s vs 41.2±9.7s,P>0.05),均优于对照组(33.5±11.3s),差异均具有统计学意义;穿越平台次数假手术组与RIC组相近(5.3±1.6 vs 4.7±1.2,P>0.05),均多于对照组(2.8±1.3),差异均具有统计学意义。在空间探索实验中,与假手术组比较,对照组大鼠的运动缺乏目的性而呈现出杂乱的曲线轨迹,RIC组相对于对照组具有明确的目的呈现出较规则的曲线。HE染色显示与假手术组(CA1:93.53±5.01;CA3:104.63±8.26)相比,对照组CA1区和CA3区存活的锥体神经元数目(CA1:51.03±4.95;CA3:78.53±5.31)明显减少(均P<0.05);而与对照组相比,RIC组大鼠CA1区和CA3区锥体神经元存活数目(CA1:80.57±7.30;CA3:92.43±8.16)明显增加(均P<0.05)。结论脑缺血再灌注损伤可引起大鼠学习记忆障碍而导致VCI。RIC能够明显改善VCI,发挥神经保护作用。展开更多
目的:分析儿童爆发性心肌炎(fulminant myocarditis,FM)的3.0T心脏磁共振(cardiac magnetic resonance,CMR)表现,探讨其在FM早期诊断及短期预后中的价值。方法:以2016年1月~2018年1月在我院收治的20例FM患儿为研究对象,所有FM患者在入...目的:分析儿童爆发性心肌炎(fulminant myocarditis,FM)的3.0T心脏磁共振(cardiac magnetic resonance,CMR)表现,探讨其在FM早期诊断及短期预后中的价值。方法:以2016年1月~2018年1月在我院收治的20例FM患儿为研究对象,所有FM患者在入院时及治疗后各进行1次CMR检查,观察入院时及治疗后患者的临床表现、CMR表现(心脏结构及功能、心肌组织特性)及短期预后情况。结果:入院及治疗后CMR检查时患儿的cTNT及BNP水平、IVST、LVEF、LVM、ESV、LVEDD、T2比值及LGE范围比较差异有统计学意义(P<0.05)。入院CMR检查时,20例患儿为EGE,17例患儿为LGE及T2信号增加,15例患心肌增厚,10例患儿LVEF增高;治疗后CMR检查时,5例患儿为LGE,1例患儿为T2信号增加,1例患儿LVEF增高。短期预后完全恢复患儿的Ⅲ度房室传导阻滞发生率未完全恢复患儿(P<0.05)、LGE面积小于未完全恢复患儿(P<0.05)。结论:CMR对儿童FM早期诊断的敏感性高,特征性强,用于儿童FM的早期诊断及短期预后评估的价值高。展开更多
文摘●AIM:To assess effectivity and safety of trifocal intraocular lenses(IOLs)and capsular tension rings in treating cataract patients with axial high myopia.●METHODS:A prospective nonrandomized controlled clinical trial was conducted.Totally 98 eyes(74 patients)who underwent femtosecond laser-assisted cataract surgery(FLACS)with trifocal IOLs were enrolled in the study and followed up for 2y after surgery:46 eyes(33 patients)with capsular tension ring implantation in the long axial lengths(AL)group(26<AL<29 mm)and 52 eyes(41 patients)in the normal AL group(22<AL<24.5 mm).Postoperative outcomes about effectivity and safety,including the subjective and objective visual quality,and postoperative complications were assessed.●RESULTS:Uncorrected distance visual acuity at 5 m and uncorrected intermediate visual acuity at 60 and 80 cm in the long AL group were significantly worse than those in the normal AL group at 3mo postoperatively(P<0.05).The differences in reading speed,spectacle independence and potential visual complaints between the two groups were not statistically significant(P>0.05).The dysfunctional lens index and total modulation transfer function(MTF)average height were similar between the two groups.The postoperative internal coma aberrations in the axial high myopia eyes were significantly higher than that in the normal AL group(P<0.05).The total satisfaction score in the long AL group(91.32±2.76)was slightly higher than that in the normal AL group(90.36±3.47),but there was no difference(P=0.136).A statistically negative correlation was found between corrected distance visual acuity(CDVA)and dysfunctional lens index(r=-0.382,P=0.009),and between CDVA and the total MTF average height(r=-0.374,P=0.01).But there was no significant correlation between CDVA and total satisfaction score(r=0.059,P=0.696).Postoperative complications mainly presented as posterior capsular opacity(PCO),retinal detachment and cystoid macular edema.There was no difference in the incidence of fundus disease(6.5%vs 3.8%,P=0.663)or PCO(17.4%vs 7.7%,P=0.217)between the two groups at two years.●CONCLUSION:The utilization of trifocal IOL and capsular tension ring implantation is beneficial for cataract patients with axial high myopia undergoing FLACS.This approach not only ensures excellent subjective feelings and objective visual quality,but also does not increase the incidence of postoperative complications.
文摘由于可再生能源发电系统固有的不确定性以及日益扩大的电网规模和区域内电站结构的复杂度对电力系统稳定运行造成影响。抽水蓄能电站作为一种调频资源,已成为区域电网负荷频率控制(load frequency control,LFC)的重要手段之一。由此,开展了抽水蓄能电站的区域LFC研究,搭建了考虑死区和发电速度约束等非线性因素下的两区域再热式汽轮机组LFC模型,设计了一个分数阶PID(fractional order PID,FOPID)控制器,利用改进Oustaloup算法实现分数阶微分算子的近似并与传统的PID控制器进行比较。仿真结果表明,文中提出的FOPID策略在控制含有非线性环节的系统时能达到更好的控制效果,表现出较强的鲁棒稳定性。对于抽水蓄能电站参与的负荷频率控制,能够缩短频率恢复时间,使二次调频的动态性能得到很大提升。
文摘目的观察远隔缺血处理对缺血再灌注损伤所致认知障碍大鼠的神经保护作用及其作用机理。方法选用雄性SD大鼠,采用双侧颈动脉闭塞(bilateral common carotid arteries occlusion,BCCAO)方法建立脑缺血再灌注致血管性认知障碍(vascular cognitive impairment,VCI)动物模型,将大鼠随机分为假手术组、对照组(VCI组)及远隔缺血处理(remote ischemic conditioning,RIC)组(VCI+RIC组)。VCI建模成功24 h后对RIC组大鼠进行RIC连续干预21 d,RIC期满后对三组大鼠采用Morris水迷宫实验进行定位航行实验和空间探索实验,定位航行实验连续进行5 d,记录第1天、第3天、第5天检测大鼠逃避潜伏期,第6天检测平台停留时间和穿越平台次数以评估认知功能。实验完成后在各组大鼠中随机选择5只取脑进行HE染色,电镜下观察各组大鼠脑白质及海马病理改变和神经元凋亡情况。结果Morri s水迷宫实验结果显示第1天、第3天、第5天对照组及RI C组大鼠逃避潜伏期较假手术组均有延长(P<0.05)。除假手术组外,另外两组大鼠逃避潜伏期时长随着训练次数增加逐渐缩短。第1天、第3天两组间差异无统计学意义,第5天RIC组成绩好于对照组(P<0.05)。第6天空间探索实验中,目标象限停留时间假手术组与RIC组相近(47.2±10.2 s vs 41.2±9.7s,P>0.05),均优于对照组(33.5±11.3s),差异均具有统计学意义;穿越平台次数假手术组与RIC组相近(5.3±1.6 vs 4.7±1.2,P>0.05),均多于对照组(2.8±1.3),差异均具有统计学意义。在空间探索实验中,与假手术组比较,对照组大鼠的运动缺乏目的性而呈现出杂乱的曲线轨迹,RIC组相对于对照组具有明确的目的呈现出较规则的曲线。HE染色显示与假手术组(CA1:93.53±5.01;CA3:104.63±8.26)相比,对照组CA1区和CA3区存活的锥体神经元数目(CA1:51.03±4.95;CA3:78.53±5.31)明显减少(均P<0.05);而与对照组相比,RIC组大鼠CA1区和CA3区锥体神经元存活数目(CA1:80.57±7.30;CA3:92.43±8.16)明显增加(均P<0.05)。结论脑缺血再灌注损伤可引起大鼠学习记忆障碍而导致VCI。RIC能够明显改善VCI,发挥神经保护作用。
文摘目的:分析儿童爆发性心肌炎(fulminant myocarditis,FM)的3.0T心脏磁共振(cardiac magnetic resonance,CMR)表现,探讨其在FM早期诊断及短期预后中的价值。方法:以2016年1月~2018年1月在我院收治的20例FM患儿为研究对象,所有FM患者在入院时及治疗后各进行1次CMR检查,观察入院时及治疗后患者的临床表现、CMR表现(心脏结构及功能、心肌组织特性)及短期预后情况。结果:入院及治疗后CMR检查时患儿的cTNT及BNP水平、IVST、LVEF、LVM、ESV、LVEDD、T2比值及LGE范围比较差异有统计学意义(P<0.05)。入院CMR检查时,20例患儿为EGE,17例患儿为LGE及T2信号增加,15例患心肌增厚,10例患儿LVEF增高;治疗后CMR检查时,5例患儿为LGE,1例患儿为T2信号增加,1例患儿LVEF增高。短期预后完全恢复患儿的Ⅲ度房室传导阻滞发生率未完全恢复患儿(P<0.05)、LGE面积小于未完全恢复患儿(P<0.05)。结论:CMR对儿童FM早期诊断的敏感性高,特征性强,用于儿童FM的早期诊断及短期预后评估的价值高。
