目的探讨老年高血压患者血压昼夜节律与颈动脉粥样硬化的关系。方法选择2016年9月～2018年6月青岛大学附属医院保健科住院的老年高血压患者117例,根据24h动态血压监测结果分为杓型组24例和异常昼夜节律组93例,异常昼夜节律组又分为非杓...目的探讨老年高血压患者血压昼夜节律与颈动脉粥样硬化的关系。方法选择2016年9月～2018年6月青岛大学附属医院保健科住院的老年高血压患者117例,根据24h动态血压监测结果分为杓型组24例和异常昼夜节律组93例,异常昼夜节律组又分为非杓型组67例,反杓型组26例。所有患者行颈动脉超声检查,检测左右颈总动脉内膜中层厚度(IMT)、颈动脉斑块及管腔狭窄情况,对颈动脉粥样硬化进行分级。测定患者空腹血糖,血脂,同型半胱氨酸,记录24h收缩压、24h舒张压、昼间收缩压、昼间舒张压、夜间收缩压和夜间舒张压。结果异常昼夜节律组左侧IMT、右侧IMT、斑块发生率和颈动脉粥样硬化程度明显高于杓型组,差异有统计学意义(P<0.05,P<0.01)。反杓型组夜间收缩压、夜间舒张压明显高于非杓型组[(132.92±15.75)mm Hg vs (122.85±14.91)mm Hg(1mm Hg=0.133kPa),(72.38±8.75)mm Hg vs (64.34±9.98)mm Hg,P<0.01]。非杓型组和反杓型组左侧IMT和左侧斑块发生率明显高于右侧,差异有统计学意义(P<0.05)。结论老年高血压患者血压昼夜节律与颈动脉粥样硬化关系密切,异常血压昼夜节律损伤靶器官概率更大,并且对左侧颈动脉内膜损害较右侧明显。展开更多
The Upper Paleozoic in the north part of Tianhuan depression in the Ordos Basin,NW China has lower hydrocarbon generation intensity and complex gas-water relationship,the main factors controlling the formation of tigh...The Upper Paleozoic in the north part of Tianhuan depression in the Ordos Basin,NW China has lower hydrocarbon generation intensity and complex gas-water relationship,the main factors controlling the formation of tight sandstone gas and the distribution of tight sandstone gas in the low hydrocarbon generation intensity area are studied.Through two-dimensional physical simulation experiment of hydrocarbon accumulation,analysis of reservoir micro-pore-throat hydrocarbon system and dissection of typical gas reservoirs,the evaluation models of gas injection pressure,reservoir physical property,and gas generation threshold were established to determine the features of tight gas reservoirs in low hydrocarbon intensity area:(1)at the burial depth of less than 3 000 m,the hydrocarbon generation intensity ofis high enough to maintain effective charging;(2)tight sandstone in large scale occurrence is conducive to accumulation of tight gas;(3)differences in reservoir physical property control the distribution of gas pool,for the channel sandstone reservoirs,ones with better physical properties generally concentrate in the middle of sandstone zone and local structural highs;ones with poor physical properties have low gas content generally.Based on the dissection of the gas reservoir in the north Tianhuan depression,the formation of tight gas reservoirs in low hydrocarbon generating intensity area are characterized by"long term continuous charging under hydrocarbon generation pressure,gas accumulation in large scale tight sandstone,pool control by difference in reservoir physical property,and local sweet spot",and the tight gas pools are distributed in discontinuous"sheets"on the plane.This understanding has been proved by expanding exploration of tight sandstone gas in the north Tianhuan depression.展开更多
文摘目的探讨老年高血压患者血压昼夜节律与颈动脉粥样硬化的关系。方法选择2016年9月～2018年6月青岛大学附属医院保健科住院的老年高血压患者117例,根据24h动态血压监测结果分为杓型组24例和异常昼夜节律组93例,异常昼夜节律组又分为非杓型组67例,反杓型组26例。所有患者行颈动脉超声检查,检测左右颈总动脉内膜中层厚度(IMT)、颈动脉斑块及管腔狭窄情况,对颈动脉粥样硬化进行分级。测定患者空腹血糖,血脂,同型半胱氨酸,记录24h收缩压、24h舒张压、昼间收缩压、昼间舒张压、夜间收缩压和夜间舒张压。结果异常昼夜节律组左侧IMT、右侧IMT、斑块发生率和颈动脉粥样硬化程度明显高于杓型组,差异有统计学意义(P<0.05,P<0.01)。反杓型组夜间收缩压、夜间舒张压明显高于非杓型组[(132.92±15.75)mm Hg vs (122.85±14.91)mm Hg(1mm Hg=0.133kPa),(72.38±8.75)mm Hg vs (64.34±9.98)mm Hg,P<0.01]。非杓型组和反杓型组左侧IMT和左侧斑块发生率明显高于右侧,差异有统计学意义(P<0.05)。结论老年高血压患者血压昼夜节律与颈动脉粥样硬化关系密切,异常血压昼夜节律损伤靶器官概率更大,并且对左侧颈动脉内膜损害较右侧明显。
基金Supported by the China National Science and Technology Major Project(2016ZX05047)
文摘The Upper Paleozoic in the north part of Tianhuan depression in the Ordos Basin,NW China has lower hydrocarbon generation intensity and complex gas-water relationship,the main factors controlling the formation of tight sandstone gas and the distribution of tight sandstone gas in the low hydrocarbon generation intensity area are studied.Through two-dimensional physical simulation experiment of hydrocarbon accumulation,analysis of reservoir micro-pore-throat hydrocarbon system and dissection of typical gas reservoirs,the evaluation models of gas injection pressure,reservoir physical property,and gas generation threshold were established to determine the features of tight gas reservoirs in low hydrocarbon intensity area:(1)at the burial depth of less than 3 000 m,the hydrocarbon generation intensity ofis high enough to maintain effective charging;(2)tight sandstone in large scale occurrence is conducive to accumulation of tight gas;(3)differences in reservoir physical property control the distribution of gas pool,for the channel sandstone reservoirs,ones with better physical properties generally concentrate in the middle of sandstone zone and local structural highs;ones with poor physical properties have low gas content generally.Based on the dissection of the gas reservoir in the north Tianhuan depression,the formation of tight gas reservoirs in low hydrocarbon generating intensity area are characterized by"long term continuous charging under hydrocarbon generation pressure,gas accumulation in large scale tight sandstone,pool control by difference in reservoir physical property,and local sweet spot",and the tight gas pools are distributed in discontinuous"sheets"on the plane.This understanding has been proved by expanding exploration of tight sandstone gas in the north Tianhuan depression.
