Using a bottom simulating reflector(BSR)on a seismic profile to identify marine gas hydrate is a traditional seismic exploration method.However,owing to the abundance differences between the gas hydrate and free gas i...Using a bottom simulating reflector(BSR)on a seismic profile to identify marine gas hydrate is a traditional seismic exploration method.However,owing to the abundance differences between the gas hydrate and free gas in different regions,the BSR may be unremarkable on the seismic profile and invisible in certain cases.With the improvement of exploration precision,difficulty arises in meeting the requirements of distinguishing the abundance differences in the gas hydrate based on BSR.Hence,we studied other sensitive attributes to ascertain the existence of gas hydrate and its abundance variations,eventually improving the success rate of drilling and productivity.In this paper,we analyzed the contradiction between the seismic profile data and drilling sampling data from the Blake Ridge.We extracted different attributes and performed multi-parameter constraint analysis based on the prestack elastic wave impedance inversion.Then,we compared the analysis results with the drilling sampling data.Eventually,we determined five sensitive attributes that can better indicate the existence of gas hydrate and its abundance variations.This method overcomes the limitations of recognizing the gas hydrate methods based on BSR or single inversion attribute.Moreover,the conclusions can notably improve the identification accuracy of marine gas hydrate and provide excellent reference significance for the recognition of marine gas hydrate.Notably,the different geological features of reservoirs feature different sensitivities to the prestacking attributes when using the prestack elastic inversion in different areas.展开更多
丙型肝炎病毒(Hepatitis C virus,HCV)引起的慢性丙型肝炎全球广泛流行,严重影响人类健康,药物治疗是防控该疾病的唯一有效途径。在干扰素-利巴韦林联合疗法在丙型肝炎治疗方面获得较好成效的基础上,直接抗病毒药物(Direct-acting antiv...丙型肝炎病毒(Hepatitis C virus,HCV)引起的慢性丙型肝炎全球广泛流行,严重影响人类健康,药物治疗是防控该疾病的唯一有效途径。在干扰素-利巴韦林联合疗法在丙型肝炎治疗方面获得较好成效的基础上,直接抗病毒药物(Direct-acting antiviral,DAA)尤其泛基因型靶向药物的使用,使病毒持续性应答率(Sustained virologic response,SVR)超过95%。靶向药物直接作用于病毒增殖的关键蛋白,大大提高病毒清除率,然而由于病毒基因变异产生耐药性成为治愈丙型肝炎的最大障碍。本综述围绕HCV流行与危害、现有丙型肝炎治疗药物、直接靶向抗病毒药物,从病毒多样性与耐药基因突变特征的角度,全面介绍丙型肝炎抗病毒治疗靶向药物与耐药发生。展开更多
基金supported by the National Natural Science Foundation of China (No. 41230318)
文摘Using a bottom simulating reflector(BSR)on a seismic profile to identify marine gas hydrate is a traditional seismic exploration method.However,owing to the abundance differences between the gas hydrate and free gas in different regions,the BSR may be unremarkable on the seismic profile and invisible in certain cases.With the improvement of exploration precision,difficulty arises in meeting the requirements of distinguishing the abundance differences in the gas hydrate based on BSR.Hence,we studied other sensitive attributes to ascertain the existence of gas hydrate and its abundance variations,eventually improving the success rate of drilling and productivity.In this paper,we analyzed the contradiction between the seismic profile data and drilling sampling data from the Blake Ridge.We extracted different attributes and performed multi-parameter constraint analysis based on the prestack elastic wave impedance inversion.Then,we compared the analysis results with the drilling sampling data.Eventually,we determined five sensitive attributes that can better indicate the existence of gas hydrate and its abundance variations.This method overcomes the limitations of recognizing the gas hydrate methods based on BSR or single inversion attribute.Moreover,the conclusions can notably improve the identification accuracy of marine gas hydrate and provide excellent reference significance for the recognition of marine gas hydrate.Notably,the different geological features of reservoirs feature different sensitivities to the prestacking attributes when using the prestack elastic inversion in different areas.
