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Three new isocoumarin derivatives from the mangrove endophytic fungus Penicillium sp. YYSJ-3 被引量:2
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作者 QIU Pei CAI Run-Lin +1 位作者 LI Lin she zhi-gang 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2020年第4期256-260,共5页
Three new isocoumarin derivatives,(S)-6,8-dihydroxy-5-(methoxymethyl)-3,7-dimethylisochroman-1-one(1),(S)-6,8-dihydroxy-3,5,7-trimethyl-isochroman-1-one(2) and(R)-2-chloro-3-(8-hydroxy-6-methoxy-1-oxo-1 H-isochromen-3... Three new isocoumarin derivatives,(S)-6,8-dihydroxy-5-(methoxymethyl)-3,7-dimethylisochroman-1-one(1),(S)-6,8-dihydroxy-3,5,7-trimethyl-isochroman-1-one(2) and(R)-2-chloro-3-(8-hydroxy-6-methoxy-1-oxo-1 H-isochromen-3-yl) propyl acetate(3), along with four known compounds(4–7) were isolated from a mangrove endophytic fungus Penicillium sp. YYSJ-3. Their structures were established on the basis of the extensive spectroscopic data and HR-ESI-MS analysis. The absolute configurations of1–3 were further determined by X-ray diffraction analysis and optical rotations. Compounds 3, 6 and 7 showed promising inhibitory activity against α-glucosidase, which were stronger than that of the positive control 1-deoxynojirimycin(IC50 141.2 μmol·L-1). 展开更多
关键词 Isocoumarin derivatives Penicillium sp. Structure elucidation α-Glucosidase inhibitory activity
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