Long non-coding RNAs(lncRNAs)play an important role in many life activities such as epigenetic material regulation,cell cycle regulation,dosage compensation and cell differentiation regulation,and are associated with ...Long non-coding RNAs(lncRNAs)play an important role in many life activities such as epigenetic material regulation,cell cycle regulation,dosage compensation and cell differentiation regulation,and are associated with many human diseases.There are many limitations in identifying and annotating lncRNAs using traditional biological experimental methods.With the development of high-throughput sequencing technology,it is of great practical significance to identify the lncRNAs from massive RNA sequence data using machine learning method.Based on the Bagging method and Decision Tree algorithm in ensemble learning,this paper proposes a method of lncRNAs gene sequence identification called BDLR.The identification results of this classification method are compared with the identification results of several models including Byes,Support Vector Machine,Logical Regression,Decision Tree and Random Forest.The experimental results show that the lncRNAs identification method named BDLR proposed in this paper has an accuracy of 86.61%in the human test set and 90.34%in the mouse for lncRNAs,which is more than the identification results of the other methods.Moreover,the proposed method offers a reference for researchers to identify lncRNAs using the ensemble learning.展开更多
基金supported by the National Natural Science Foundation of China(61502243,61502247,61572263)China Postdoctoral Science Foundation(2018M632349)+1 种基金Zhejiang Engineering Research Center of Intelligent Medicine under 2016E10011,Foundation of Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province(SHEL221-001)Natural Science Foundation of the Higher Education Institutions of Jiangsu Province in China(No.16KJD520003).
文摘Long non-coding RNAs(lncRNAs)play an important role in many life activities such as epigenetic material regulation,cell cycle regulation,dosage compensation and cell differentiation regulation,and are associated with many human diseases.There are many limitations in identifying and annotating lncRNAs using traditional biological experimental methods.With the development of high-throughput sequencing technology,it is of great practical significance to identify the lncRNAs from massive RNA sequence data using machine learning method.Based on the Bagging method and Decision Tree algorithm in ensemble learning,this paper proposes a method of lncRNAs gene sequence identification called BDLR.The identification results of this classification method are compared with the identification results of several models including Byes,Support Vector Machine,Logical Regression,Decision Tree and Random Forest.The experimental results show that the lncRNAs identification method named BDLR proposed in this paper has an accuracy of 86.61%in the human test set and 90.34%in the mouse for lncRNAs,which is more than the identification results of the other methods.Moreover,the proposed method offers a reference for researchers to identify lncRNAs using the ensemble learning.
