Conventional sutures used in surgical procedures often lack the capability to effectively monitor physical and chemical activities or the microbial environment of surgical wounds due to their inadequate mechanical pro...Conventional sutures used in surgical procedures often lack the capability to effectively monitor physical and chemical activities or the microbial environment of surgical wounds due to their inadequate mechanical properties,insufficient electrical accuracy and unstability.Here,we present a straightforward layer-by-layer coating technique that utilizes 3-glycidoxypropyltrimethoxysilane(CA),graphene oxide(GO),and ascorbic acid(AA)to develop conductive silk-based surgical sutures(CA-rGSFS).The CA-rGSFS feature a continuous reduced graphene oxide(rGO)film on their surface,forming robust hydrogen bonds with silk fibroin.The reduction process of rGO is confirmed through Raman analysis,demonstrating an enhanced D peak to G peak ratio.Notably,the CA-rGSFS exhibit exceptional mechanical properties and efficient electron transmission,with a knot-pull tensile strength of 2089.72±1.20 cN and an electrical conductivity of 130.30±11.34 S/m,respectively,meeting the requirements specified by the United States Pharmacopeia(USP)for 2-0 sutures.These novel CA-rGSFS demonstrate the ability to accurately track resistance changes in various fluid environments with rapid response,including saline,intestinal,and gastric fluids.The suture also retains remarkable stretchablility and stability even after enduring 3000 tensile cycles,highlighting their potential for precise surgical site monitoring during the wound healing process.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.82374295)the support of the National Key R&D Program of China(Grant No.2021YFE0111100)+2 种基金the Science and Technology Partnership Program by the Ministry of Science and Technology of China(Grant No.KY202201002)Jiangsu Provincial Department of Science and Technology(Grant No.BZ2022017)China National Textile and Apparel Council(Grant No.J202002)。
文摘Conventional sutures used in surgical procedures often lack the capability to effectively monitor physical and chemical activities or the microbial environment of surgical wounds due to their inadequate mechanical properties,insufficient electrical accuracy and unstability.Here,we present a straightforward layer-by-layer coating technique that utilizes 3-glycidoxypropyltrimethoxysilane(CA),graphene oxide(GO),and ascorbic acid(AA)to develop conductive silk-based surgical sutures(CA-rGSFS).The CA-rGSFS feature a continuous reduced graphene oxide(rGO)film on their surface,forming robust hydrogen bonds with silk fibroin.The reduction process of rGO is confirmed through Raman analysis,demonstrating an enhanced D peak to G peak ratio.Notably,the CA-rGSFS exhibit exceptional mechanical properties and efficient electron transmission,with a knot-pull tensile strength of 2089.72±1.20 cN and an electrical conductivity of 130.30±11.34 S/m,respectively,meeting the requirements specified by the United States Pharmacopeia(USP)for 2-0 sutures.These novel CA-rGSFS demonstrate the ability to accurately track resistance changes in various fluid environments with rapid response,including saline,intestinal,and gastric fluids.The suture also retains remarkable stretchablility and stability even after enduring 3000 tensile cycles,highlighting their potential for precise surgical site monitoring during the wound healing process.
