Objective:To explore the therapeutic effect of Shenlan oral liquid on thrombosis rats and hyperlipidemia mice.Methods:Male Wistar rats were divided into four groups randomly:the control group,the Shenlan oral liquid g...Objective:To explore the therapeutic effect of Shenlan oral liquid on thrombosis rats and hyperlipidemia mice.Methods:Male Wistar rats were divided into four groups randomly:the control group,the Shenlan oral liquid groups(high dosage and low dosage),and the positive control group.Rats in the control group were treated with dd water intragastriclly;in the positive control group,rats were treated intragastric with aspirin.Rats were treated with different drugs intragastric for continuous 22 d.In the hyperlipidemia experiment,mice were fed with high-fat diet to induce hyperlipidemia model mice,then randomly divided into five groups;the control group,the model group,the atorvastatin calcium positive control group,and the Shenlan oral liquid groups(high dosage and low dosage).The serum lipid and body weight changes of mice were observed after 6 weeks.Animals in Shenlan oral liquid high and low dosage were treated intragastric with six times and double the clinical dose.Results:After treatment,the mix blocking rate and average blocking rate of the vascular after electrical stimulation were obviously reduced in aspirin group,and Shenlan oral liquid high and low dose groups(P<0.05 or P<0.01).The maximum aggregation rate was significantly lower than that of control group(P<0.05 or P<0.01),and the normal coagulation function was not affected.In the treatment of hyperlipidemia,the effects of Shenlan oral liquid were measured on the total cholesterol(TC),triacylglycerol(total triglyceride,TG),low density lipoprotein(LDL-C)and high-density lipoprotein(HDL-C)with the hyperlipidemia mice.After 2 weeks administration,the serum TG level of Shenlan oral liquid high-dose group decreased compared with the model group.The TG level of serum in Shenlan oral liquid high-dose group significantly decreased compared with the model group from the fourth week(P<0.05).After 6 weeks administration,Shenlan oral liquid high-dose and low-dose group and positive drugs reached to the same therapeutic effect.Compared with model group,serum TG level was significantly decreased(P<0.05 or P<0.01).Conclusion:Shenlan oral liquid can decrease the thrombosis formation in rats and inhibit the lipid level in blood in hyperlipidemia mice.展开更多
近年来,碳捕集、利用与封存(CCUS)技术在全球范围内受到广泛关注。本文利用文献计量方法对2000—2020年来自Web of Science数据库中CCUS相关科学文献进行了系统统计与分析。主要统计结果表明:1)美国CCUS技术领域研究较早且此后长期处于...近年来,碳捕集、利用与封存(CCUS)技术在全球范围内受到广泛关注。本文利用文献计量方法对2000—2020年来自Web of Science数据库中CCUS相关科学文献进行了系统统计与分析。主要统计结果表明:1)美国CCUS技术领域研究较早且此后长期处于领先地位,中国发文量和H指数相对靠前,但篇均被引频次较低。全球主要机构中,美国能源部、中国科学院和伦敦帝国理工学院对CCUS技术的研究实力和投入远远高于其他机构,其出版总量占全球出版总量的10.01%。2)从国家间合作来看,美国一直是各国合作的主要对象。然而随着时间的推移,国家间合作的聚集性逐渐降低,各国在CCUS技术领域的差距有所减小,近年来,再度出现聚集性。3)从关键词随时间的变化可以看出,除CCUS技术本身外,CO2捕集、运输和封存一直是CCUS领域研究重点。近年来,CO2利用途径和利用方式的相关研究逐渐增加,在此阶段,生物能源、负排放、生物能源碳捕集与封存(BECCS)等关键词热度迅速上升,CCUS技术经济性研究热度也不断攀升。CO2利用、负排放技术及CCUS技术经济性研究将持续成为未来CCUS领域研究热点。展开更多
基金supported by Free Exploration Project Funded by Central Public Welfare Research Institutes(ZZ13-YQ-103)。
文摘Objective:To explore the therapeutic effect of Shenlan oral liquid on thrombosis rats and hyperlipidemia mice.Methods:Male Wistar rats were divided into four groups randomly:the control group,the Shenlan oral liquid groups(high dosage and low dosage),and the positive control group.Rats in the control group were treated with dd water intragastriclly;in the positive control group,rats were treated intragastric with aspirin.Rats were treated with different drugs intragastric for continuous 22 d.In the hyperlipidemia experiment,mice were fed with high-fat diet to induce hyperlipidemia model mice,then randomly divided into five groups;the control group,the model group,the atorvastatin calcium positive control group,and the Shenlan oral liquid groups(high dosage and low dosage).The serum lipid and body weight changes of mice were observed after 6 weeks.Animals in Shenlan oral liquid high and low dosage were treated intragastric with six times and double the clinical dose.Results:After treatment,the mix blocking rate and average blocking rate of the vascular after electrical stimulation were obviously reduced in aspirin group,and Shenlan oral liquid high and low dose groups(P<0.05 or P<0.01).The maximum aggregation rate was significantly lower than that of control group(P<0.05 or P<0.01),and the normal coagulation function was not affected.In the treatment of hyperlipidemia,the effects of Shenlan oral liquid were measured on the total cholesterol(TC),triacylglycerol(total triglyceride,TG),low density lipoprotein(LDL-C)and high-density lipoprotein(HDL-C)with the hyperlipidemia mice.After 2 weeks administration,the serum TG level of Shenlan oral liquid high-dose group decreased compared with the model group.The TG level of serum in Shenlan oral liquid high-dose group significantly decreased compared with the model group from the fourth week(P<0.05).After 6 weeks administration,Shenlan oral liquid high-dose and low-dose group and positive drugs reached to the same therapeutic effect.Compared with model group,serum TG level was significantly decreased(P<0.05 or P<0.01).Conclusion:Shenlan oral liquid can decrease the thrombosis formation in rats and inhibit the lipid level in blood in hyperlipidemia mice.
文摘近年来,碳捕集、利用与封存(CCUS)技术在全球范围内受到广泛关注。本文利用文献计量方法对2000—2020年来自Web of Science数据库中CCUS相关科学文献进行了系统统计与分析。主要统计结果表明:1)美国CCUS技术领域研究较早且此后长期处于领先地位,中国发文量和H指数相对靠前,但篇均被引频次较低。全球主要机构中,美国能源部、中国科学院和伦敦帝国理工学院对CCUS技术的研究实力和投入远远高于其他机构,其出版总量占全球出版总量的10.01%。2)从国家间合作来看,美国一直是各国合作的主要对象。然而随着时间的推移,国家间合作的聚集性逐渐降低,各国在CCUS技术领域的差距有所减小,近年来,再度出现聚集性。3)从关键词随时间的变化可以看出,除CCUS技术本身外,CO2捕集、运输和封存一直是CCUS领域研究重点。近年来,CO2利用途径和利用方式的相关研究逐渐增加,在此阶段,生物能源、负排放、生物能源碳捕集与封存(BECCS)等关键词热度迅速上升,CCUS技术经济性研究热度也不断攀升。CO2利用、负排放技术及CCUS技术经济性研究将持续成为未来CCUS领域研究热点。
