衰老是在细胞、组织和器官水平上发生的生理性内稳态的渐进性损害过程。就代谢角度而言,该过程主要表现为体成分、胰岛素抵抗、自噬功能障碍、线粒体和炎症反应的变化,其中涉及生长激素、胰岛素/胰岛素样生长因子1及各种能量感应系统如...衰老是在细胞、组织和器官水平上发生的生理性内稳态的渐进性损害过程。就代谢角度而言,该过程主要表现为体成分、胰岛素抵抗、自噬功能障碍、线粒体和炎症反应的变化,其中涉及生长激素、胰岛素/胰岛素样生长因子1及各种能量感应系统如AMP活化蛋白激酶(AMP-activated protein kinase,AMPK).展开更多
Measurements of total reaction cross sections(σR)for some proton-rich nuclei(N=11-15 isotones)on carbon target at intermediate energies have been performed on the Radioactive Ion Beam Line of the Heavy Ion Research F...Measurements of total reaction cross sections(σR)for some proton-rich nuclei(N=11-15 isotones)on carbon target at intermediate energies have been performed on the Radioactive Ion Beam Line of the Heavy Ion Research Facility in Lanzhou.A large enhancement ofσR for ^(27)P has been observed than for its neighbors.Evidence for a proton halo in ^(27)P has been revealed in the Glauber analysis of the total reaction cross sections in terms of the difference factor d.展开更多
The directed and elliptic flow in collisions of ^(112)Sn+^(112)Sn at energies from 35 to 90 MeV/nucleon are studied in an isospin-dependent quantum molecule dynamics model.With increasing incident energy,the directed ...The directed and elliptic flow in collisions of ^(112)Sn+^(112)Sn at energies from 35 to 90 MeV/nucleon are studied in an isospin-dependent quantum molecule dynamics model.With increasing incident energy,the directed flow rises from negative to positive.Its magnitude depends on the nuclear equation of state(EOS).However,the elliptic flow decreases with increasing incident energy and its magnitude is not very sensible to EOS.Systematic studies of the impact parameter dependence and the cluster mass dependence are also performed.The study of directed flow at intermediate energies thus provides a means of extracting the information on the nuclear equation of state.展开更多
Total reaction cross sections σR for some proton-rich isotones (N = 10) near ^(23)Al on a carbon target have been measured at intermediate energies in the experiment performed at the Radioactive Ion Beam Line of the ...Total reaction cross sections σR for some proton-rich isotones (N = 10) near ^(23)Al on a carbon target have been measured at intermediate energies in the experiment performed at the Radioactive Ion Beam Line of the Heavy Ion Research Facility in Lanzhou. The Z-dependence of σR shows a remarkable enhancement for ^(23)Al relative to its neighbours. The difference factor d has been deduced from the measured σR by using the Glauber or Boltzmann-Uehling-Uhlenbeck models. From the above analysis, a possible one-proton halo structure is suggested for ^(23)Al.展开更多
Fragments produced in the reactions of 69 MeV/nucleon ^(36)Ar and ^(55)MeV/nucleon ^(40)Ar on a Be target have been measured experimentally.The isotopic distributions from fragmentation reaction for both projectiles a...Fragments produced in the reactions of 69 MeV/nucleon ^(36)Ar and ^(55)MeV/nucleon ^(40)Ar on a Be target have been measured experimentally.The isotopic distributions from fragmentation reaction for both projectiles are reproduced by using a modified statistical abrasion-ablation model.Strong isospin effect exhibits in the isotopic distributions produced in ^(36)Ar and ^(40)Ar fragmentation.Experimental evidence is seen for the disappearance of the isospin effect in fragmentation reaction.展开更多
The emission of clusters in the nuclear dissociation was investigated within the framework of isospin dependent lattice gas model.As observed in the recent experimental data,it was found that the emission probability ...The emission of clusters in the nuclear dissociation was investigated within the framework of isospin dependent lattice gas model.As observed in the recent experimental data,it was found that the emission probability of individual cluster is Poissonian and thermal scaling was observed in the linear Arrhenius plots made from the average multiplicity of each cluster as a function of the inverse temperature.The‘emission barriers’were extracted from the slopes of the Arrhenius plots and mainly depends on the surface energy of the cluster.展开更多
Measurements of the total reaction cross section for^(12-16)C,^(14-17)N and^(16-18)O on carbon target at intermediate energies were performed on RIBLL of HIRFL.A larger enhancement ofσR for^(15)C was observed than th...Measurements of the total reaction cross section for^(12-16)C,^(14-17)N and^(16-18)O on carbon target at intermediate energies were performed on RIBLL of HIRFL.A larger enhancement ofσR for^(15)C was observed than that for its neighbors.The analysis of these data indicates possible existence of an anomalous nuclear structure in^(15)C.A new quantity was suggested as the criterion to distinguish anomalous structure nuclei from normal nuclei.展开更多
Fragments produced in the reaction of 60 MeV/n^(18)O on Be have been measured experimentally.The isotopic distribution of fragmentation reaction is well reproduced by a modified statistical abrasion-ablation model It ...Fragments produced in the reaction of 60 MeV/n^(18)O on Be have been measured experimentally.The isotopic distribution of fragmentation reaction is well reproduced by a modified statistical abrasion-ablation model It is predicted that the isotopic distribution shifts toward the neutron rich side for neutron rich projectile,but this isospin effect decreases with the increase of the atomic number difference Z-Z_(A)and disappears at last,where Z and Z_(A)are atomic numbers of the isotopic distribution and the projectile respectively.展开更多
The excitation function and isospin dependencies ofσR have been investigated by using the Boltzmann-Uehling-Uhlenbeck(BUU)model with a square-type density distribution.When the width parameter of the square distribut...The excitation function and isospin dependencies ofσR have been investigated by using the Boltzmann-Uehling-Uhlenbeck(BUU)model with a square-type density distribution.When the width parameter of the square distribution is obtained by fittingσR at relativistic energies,the BUU-model can reproduce the experimental data at intermediate energies better than Glauber model.The systematical underestimation ofσR at intermediate energy by Glauber model was removed out now by BUU calculation framework.It is also found thatσR is sensitive to nuclear equation of state andσin-NN medium.The difference factor d defined in text is sensitive to the nuclear structure such as neutron halo and neutron skin,etc.展开更多
The experimental measurement of the total interaction cross sections of N,C,B,and Be isotopes on 12C target at medium energies is described.A new formula that gives a good description of the energy-range relationship ...The experimental measurement of the total interaction cross sections of N,C,B,and Be isotopes on 12C target at medium energies is described.A new formula that gives a good description of the energy-range relationship of energetic ions over a wide energy range is presented.The energy calibration of detectors is made by a Monte Carlo simulation method based on this new formula.展开更多
Isospin effects of the critical phenomena were studied via Xe isotopes in the frame of the lattice gas model.All the critical temperatures for four Xe isotopes are close to 5.5 MeV at the same freeze-out density of ab...Isospin effects of the critical phenomena were studied via Xe isotopes in the frame of the lattice gas model.All the critical temperatures for four Xe isotopes are close to 5.5 MeV at the same freeze-out density of about 0.39ρ0.The critical values of power law parameter of mass distribution,mean multiplicity of intermediate mass fragments,information entropy and Campi's second moment show minor dependence on the isospin at the critical point.展开更多
A microscopic semi-classical approach,i.e.,the linearized Vlasov equation with a collision term treated by the relaxation time approximation,is simply described and is used to investigate the giant dipole resonance(GD...A microscopic semi-classical approach,i.e.,the linearized Vlasov equation with a collision term treated by the relaxation time approximation,is simply described and is used to investigate the giant dipole resonance(GDR)from hot super heavy compound system.The possibility of such GDRγrays emission is described also according to the fission delay.For Au+Au system(A=392)and Xe+U system(A=374),the temperature dependence of strength distribution of GDRγrays and the deformation effect on GDRγrays are discussed in framework of this approach.展开更多
目的:全面评价抗阻运动改善阿尔茨海默症(Alzheimer’s disease,AD)患者认知功能的效果,分析不同方式的抗阻运动对AD患者认知功能的干预效果,探讨抗阻运动改善AD的有效方案,为预防和治疗AD提供循证依据。方法:通过检索Pub Med、web of s...目的:全面评价抗阻运动改善阿尔茨海默症(Alzheimer’s disease,AD)患者认知功能的效果,分析不同方式的抗阻运动对AD患者认知功能的干预效果,探讨抗阻运动改善AD的有效方案,为预防和治疗AD提供循证依据。方法:通过检索Pub Med、web of science、Embase、中国知网等数据库,收集相关随机对照试验,按照纳入和排除标准筛选文献;应用JADAD评分量表进行文献质量评价,提取数据后采用Rev Man 5.4软件进行Meta分析。结果:抗阻运动对AD患者认知功能干预效果的合并效应量[SMD=0.32、95%CI(0.09,0.55),p=0.006 <0.01]中方块与无效线无交叉;低频率抗阻运动对AD患者认知功能干预效果的合并效应量中方块与无效线有交叉[SMD=0.21、95%CI(-0.11,0.54),P=0.20> 0.05];高频率抗阻运动[WMD=1.40、95%CI(0.38,2.42),P=0.007 <0.01]和高强度抗阻运动[SMD=0.48、95%CI(0.18,0.79),P=0.002<0.01]对AD患者认知功能干预效果的合并效应量均落在无效线右侧。结论:抗阻运动可显著改善AD患者的认知功能,高频率抗阻运动干预效果优于低频率抗阻运动。此外,高强度抗阻运动也可显著改善AD患者的认知功能。展开更多
AMPK(5′AMP-activated protein kinase)是AMP激活的,由催化亚基α(α1/α2)、调节亚基β(β1/β2)和γ(γ1/γ2/γ3)构成的异源三聚体蛋白激酶。营养物质缺乏(无糖或低氧)、二甲双胍、AMPK激活剂AICAR和运动皆能激活骨骼肌AMPK,而AMPK...AMPK(5′AMP-activated protein kinase)是AMP激活的,由催化亚基α(α1/α2)、调节亚基β(β1/β2)和γ(γ1/γ2/γ3)构成的异源三聚体蛋白激酶。营养物质缺乏(无糖或低氧)、二甲双胍、AMPK激活剂AICAR和运动皆能激活骨骼肌AMPK,而AMPK主要促进骨骼肌分解代谢,抑制其合成代谢。其中,运动主要通过上调骨骼肌[AMP]/[ATP]或[ADP]/[ATP]比率促进AMPKαThr172位点磷酸化,从而激活骨骼肌AMPK介导的糖脂代谢信号通路,包括AMPK/TBC1D1/TBC1D4信号通路调控的GLUT4转位以促进葡萄糖摄取,以及AMPK/ACC(乙酰辅酶A羧化酶)信号通路结合线粒体蛋白转移酶CPT1/2和脂肪酸转运蛋白FAT/CD36、FABPpm和FATP1/4共同促进的骨骼肌脂肪酸氧化。为突出AMPK调控运动中骨骼肌糖脂代谢的重要性,本文分别阐述了运动对骨骼肌AMPK的调控作用,运动在骨骼肌AMPK介导糖、脂代谢中的调控作用。深度理解运动过程中AMPK调控骨骼肌糖脂代谢的细胞分子机制有助于将AMPK开发成治疗代谢类疾病的潜在有效靶向因子。展开更多
文摘衰老是在细胞、组织和器官水平上发生的生理性内稳态的渐进性损害过程。就代谢角度而言,该过程主要表现为体成分、胰岛素抵抗、自噬功能障碍、线粒体和炎症反应的变化,其中涉及生长激素、胰岛素/胰岛素样生长因子1及各种能量感应系统如AMP活化蛋白激酶(AMP-activated protein kinase,AMPK).
基金Supported by the Major State Basic Research Development Program in China under Contract No.G200077400.
文摘Measurements of total reaction cross sections(σR)for some proton-rich nuclei(N=11-15 isotones)on carbon target at intermediate energies have been performed on the Radioactive Ion Beam Line of the Heavy Ion Research Facility in Lanzhou.A large enhancement ofσR for ^(27)P has been observed than for its neighbors.Evidence for a proton halo in ^(27)P has been revealed in the Glauber analysis of the total reaction cross sections in terms of the difference factor d.
基金Supported by the National Natural Science Foundation of China under Grant No.19705012the National Natural Foundation for Distinguished Young Scholars under Science Grant No.19725521+1 种基金Shanghai Science and Technology Development Funds under Grant No.97QA14038Special Foundation of the President of the Chinese Academy of Sciences and Major State Basic Research Development Program under Contract No.G200077400.
文摘The directed and elliptic flow in collisions of ^(112)Sn+^(112)Sn at energies from 35 to 90 MeV/nucleon are studied in an isospin-dependent quantum molecule dynamics model.With increasing incident energy,the directed flow rises from negative to positive.Its magnitude depends on the nuclear equation of state(EOS).However,the elliptic flow decreases with increasing incident energy and its magnitude is not very sensible to EOS.Systematic studies of the impact parameter dependence and the cluster mass dependence are also performed.The study of directed flow at intermediate energies thus provides a means of extracting the information on the nuclear equation of state.
基金Supported by the Major State Basic Research Development Program under contract No.G200077400。
文摘Total reaction cross sections σR for some proton-rich isotones (N = 10) near ^(23)Al on a carbon target have been measured at intermediate energies in the experiment performed at the Radioactive Ion Beam Line of the Heavy Ion Research Facility in Lanzhou. The Z-dependence of σR shows a remarkable enhancement for ^(23)Al relative to its neighbours. The difference factor d has been deduced from the measured σR by using the Glauber or Boltzmann-Uehling-Uhlenbeck models. From the above analysis, a possible one-proton halo structure is suggested for ^(23)Al.
基金Supported by the Major State Basic Research Development Program in China Under Contract No.G200077400.
文摘Fragments produced in the reactions of 69 MeV/nucleon ^(36)Ar and ^(55)MeV/nucleon ^(40)Ar on a Be target have been measured experimentally.The isotopic distributions from fragmentation reaction for both projectiles are reproduced by using a modified statistical abrasion-ablation model.Strong isospin effect exhibits in the isotopic distributions produced in ^(36)Ar and ^(40)Ar fragmentation.Experimental evidence is seen for the disappearance of the isospin effect in fragmentation reaction.
基金Supported in part by the National Natural Science Foundation of China for Distinguished Young Scholars under Grant No.19725521the National Natural Science Foundation of China under Grant No.19705012the Major State Basic Research Development Program of China under Contract No.G200077400。
文摘The emission of clusters in the nuclear dissociation was investigated within the framework of isospin dependent lattice gas model.As observed in the recent experimental data,it was found that the emission probability of individual cluster is Poissonian and thermal scaling was observed in the linear Arrhenius plots made from the average multiplicity of each cluster as a function of the inverse temperature.The‘emission barriers’were extracted from the slopes of the Arrhenius plots and mainly depends on the surface energy of the cluster.
基金Supported by the National Natural Science Foundation of China for Distinguished Young Scholar under Grand No.19625513National Natural Science Foundation of China under Grant No.19675059+1 种基金Shanghai Science,Technology Development Fund under Grant No.96XD14011Major State Basic Research Development Program(G200077400).
文摘Measurements of the total reaction cross section for^(12-16)C,^(14-17)N and^(16-18)O on carbon target at intermediate energies were performed on RIBLL of HIRFL.A larger enhancement ofσR for^(15)C was observed than that for its neighbors.The analysis of these data indicates possible existence of an anomalous nuclear structure in^(15)C.A new quantity was suggested as the criterion to distinguish anomalous structure nuclei from normal nuclei.
基金Supported by the National Natural Science Foundation of China for Distinguished Young Scholar under Grand No.19625513National Natural Science Foundation of China under Grant No.19675059Shanghai Science and Technology Development Fund under Grant No.96XD14011.
文摘Fragments produced in the reaction of 60 MeV/n^(18)O on Be have been measured experimentally.The isotopic distribution of fragmentation reaction is well reproduced by a modified statistical abrasion-ablation model It is predicted that the isotopic distribution shifts toward the neutron rich side for neutron rich projectile,but this isospin effect decreases with the increase of the atomic number difference Z-Z_(A)and disappears at last,where Z and Z_(A)are atomic numbers of the isotopic distribution and the projectile respectively.
基金Supported by the National Natural Science Foundation of China for Distinguished Young Scholar under Grant No.19625513the National Natural Science Foundation of China under Grant No.19675059,the Major State Basic Research Development Program under Contract No.G200077400the Shanghai Science and Technology Development Fund under Grant No.96XD14011.
文摘The excitation function and isospin dependencies ofσR have been investigated by using the Boltzmann-Uehling-Uhlenbeck(BUU)model with a square-type density distribution.When the width parameter of the square distribution is obtained by fittingσR at relativistic energies,the BUU-model can reproduce the experimental data at intermediate energies better than Glauber model.The systematical underestimation ofσR at intermediate energy by Glauber model was removed out now by BUU calculation framework.It is also found thatσR is sensitive to nuclear equation of state andσin-NN medium.The difference factor d defined in text is sensitive to the nuclear structure such as neutron halo and neutron skin,etc.
基金Supported by the National Science Foundation of China for Distinguished Young Scholar under Grand No.19625513.
文摘The experimental measurement of the total interaction cross sections of N,C,B,and Be isotopes on 12C target at medium energies is described.A new formula that gives a good description of the energy-range relationship of energetic ions over a wide energy range is presented.The energy calibration of detectors is made by a Monte Carlo simulation method based on this new formula.
基金Supported by the National Natural Science Foundation of China for Distinguished Young Scholar under Grant No.19725521)the National Natural Science Foundation of China under Grant No.19705012+2 种基金the Science and Technology Development Foundation of Shanghai under Grant No.97QA14038the Special Project of the Presidential Foundation of Chinese Academy of Sciencesthe Scientific Research Foundations for Returned Overseas Chinese Scholar by the National Human Resource Administration and Education Administration of China。
文摘Isospin effects of the critical phenomena were studied via Xe isotopes in the frame of the lattice gas model.All the critical temperatures for four Xe isotopes are close to 5.5 MeV at the same freeze-out density of about 0.39ρ0.The critical values of power law parameter of mass distribution,mean multiplicity of intermediate mass fragments,information entropy and Campi's second moment show minor dependence on the isospin at the critical point.
基金Supported by the National Natural Science Foundation of China under Grant Nos.19675059,19675960,19705012,and 19725521Shanghai Science and Technique Development Foundation under Grant Nos.96XD 14011,97QA14038,and 97XD14020。
文摘A microscopic semi-classical approach,i.e.,the linearized Vlasov equation with a collision term treated by the relaxation time approximation,is simply described and is used to investigate the giant dipole resonance(GDR)from hot super heavy compound system.The possibility of such GDRγrays emission is described also according to the fission delay.For Au+Au system(A=392)and Xe+U system(A=374),the temperature dependence of strength distribution of GDRγrays and the deformation effect on GDRγrays are discussed in framework of this approach.
文摘目的:全面评价抗阻运动改善阿尔茨海默症(Alzheimer’s disease,AD)患者认知功能的效果,分析不同方式的抗阻运动对AD患者认知功能的干预效果,探讨抗阻运动改善AD的有效方案,为预防和治疗AD提供循证依据。方法:通过检索Pub Med、web of science、Embase、中国知网等数据库,收集相关随机对照试验,按照纳入和排除标准筛选文献;应用JADAD评分量表进行文献质量评价,提取数据后采用Rev Man 5.4软件进行Meta分析。结果:抗阻运动对AD患者认知功能干预效果的合并效应量[SMD=0.32、95%CI(0.09,0.55),p=0.006 <0.01]中方块与无效线无交叉;低频率抗阻运动对AD患者认知功能干预效果的合并效应量中方块与无效线有交叉[SMD=0.21、95%CI(-0.11,0.54),P=0.20> 0.05];高频率抗阻运动[WMD=1.40、95%CI(0.38,2.42),P=0.007 <0.01]和高强度抗阻运动[SMD=0.48、95%CI(0.18,0.79),P=0.002<0.01]对AD患者认知功能干预效果的合并效应量均落在无效线右侧。结论:抗阻运动可显著改善AD患者的认知功能,高频率抗阻运动干预效果优于低频率抗阻运动。此外,高强度抗阻运动也可显著改善AD患者的认知功能。
文摘AMPK(5′AMP-activated protein kinase)是AMP激活的,由催化亚基α(α1/α2)、调节亚基β(β1/β2)和γ(γ1/γ2/γ3)构成的异源三聚体蛋白激酶。营养物质缺乏(无糖或低氧)、二甲双胍、AMPK激活剂AICAR和运动皆能激活骨骼肌AMPK,而AMPK主要促进骨骼肌分解代谢,抑制其合成代谢。其中,运动主要通过上调骨骼肌[AMP]/[ATP]或[ADP]/[ATP]比率促进AMPKαThr172位点磷酸化,从而激活骨骼肌AMPK介导的糖脂代谢信号通路,包括AMPK/TBC1D1/TBC1D4信号通路调控的GLUT4转位以促进葡萄糖摄取,以及AMPK/ACC(乙酰辅酶A羧化酶)信号通路结合线粒体蛋白转移酶CPT1/2和脂肪酸转运蛋白FAT/CD36、FABPpm和FATP1/4共同促进的骨骼肌脂肪酸氧化。为突出AMPK调控运动中骨骼肌糖脂代谢的重要性,本文分别阐述了运动对骨骼肌AMPK的调控作用,运动在骨骼肌AMPK介导糖、脂代谢中的调控作用。深度理解运动过程中AMPK调控骨骼肌糖脂代谢的细胞分子机制有助于将AMPK开发成治疗代谢类疾病的潜在有效靶向因子。
