Background Accurate intraoperative diagnosis of sentinel lymph node （SLN） metastases enables the selection of patients for axillary lymph node dissections during the same operation, reducing the need for a second op...Background Accurate intraoperative diagnosis of sentinel lymph node （SLN） metastases enables the selection of patients for axillary lymph node dissections during the same operation, reducing the need for a second operation. The present study aimed to prospectively compare the GeneSearchTM Breast Lymph Node （BLN） Assay with touch imprint cytology （TIC） for intraoperative evaluation of SLNs.Methods SLNs were sectioned in 1.5-3.0 mm pieces. TIC was performed on all pieces and the BLN Assay and postoperative histology evaluations were performed on different alternating node pieces. Overall performance of the BLN Assay was compared with that of TIC relative to the postoperative histology results.Results A total of 90 patients enrolled in the study. Complete intraoperative data for both the BLN Assay and TIC were collected in 86 patients. The sensitivity, specificity, and overall accuracy of the BLN Assay were 82%, 97%, and 92%,respectively on a per patient basis compared with those of TIC which were 67%, 100%, and 90%.Conclusions Performance of the BLN Assay was superior to that of TIC and the additional application of TIC did not help improve the total sensitivity and accuracy of the intraoperative assessment. The existence of ectopic breast tissue might be a possible cause of false positive for the BLN assay. In addition, the BLN Assay complements histopathology assessment and can minimize sampling error without increasing pathologists＇ workload.展开更多
Background Three randomised trials have demonstrated that combining bevacizumab with first-line chemotherapy significantly improves progression-free survival versus chemotherapy alone in HER2-negative locally recurren...Background Three randomised trials have demonstrated that combining bevacizumab with first-line chemotherapy significantly improves progression-free survival versus chemotherapy alone in HER2-negative locally recurrent/metastatic breast cancer （LR/mBC）. However, data from Chinese populations are limited and possible differences between ethnic and geographic populations are unknown. This study was conducted to determine whether there are differences in safety and efficacy in patients with HER2-negative LR/mRC between Chinese and Western populations after they receive first-line bevacizumab combined with taxane-based therapy.展开更多
Background Seroma formation is one of the most common complications after breast cancer surgery. Various risk factors have been evaluated for their associations with the development of seromas in Western populations. ...Background Seroma formation is one of the most common complications after breast cancer surgery. Various risk factors have been evaluated for their associations with the development of seromas in Western populations. However, similar data are not available in Chinese series. Therefore, we sought to investigate the potential risk factors for Chinese breast cancer patients. Methods A prospective study of female breast cancer patients undergoing surgery was carried out in Cancer Hospital of Fudan Unversity, Shanghai, China. Univariate analyses were performed by chi-square test or Student＇s t test or Mann-Whitney test and multivariate analyses by stepwise Logistic regression. The logistic model included age （years）, total serum protein concentration （g/L）, drainage volume on postoperative day 3 （POD 3; ml） and time to daily drainage volume not more than 30 ml （TTV30; days）. Results A total of 158 patients with breast cancer were studied. The mean age at diagnosis was （52.14±10.77） years （range 25-92）. During the follow-up period, 24 （15.2%） patients developed seromas. Calculated as continuous variables in the stepwise Logistic regression, age （0R=1.090, 95% CI 1.028-1.155, P=0.004）, total serum protein concentration （OR=0.886, 95% Cl 0.791-0.992, P=0.036）, drainage volume on POD3 （OR=1.013, 95% Cl 1.002-1.023, P=0.017） and TTV30 （OR=1.273, 95% CI 1.039-1.561, P=0.020） were independent risk factors for seroma formation. Additionally, significant difference in daily drainage volume was substantiated in the analysis by seroma formation （P=0.034） rather than by type of surgery （P=0.713）. Conclusions Although the pathogenesis of seroma remains controversial, such risk factors as age, nutritional status, drainage volume on POD3 and TTV30 should be considered for prediction and prevention of seroma formation in Chinese breast cancer patients.展开更多
文摘Background Accurate intraoperative diagnosis of sentinel lymph node （SLN） metastases enables the selection of patients for axillary lymph node dissections during the same operation, reducing the need for a second operation. The present study aimed to prospectively compare the GeneSearchTM Breast Lymph Node （BLN） Assay with touch imprint cytology （TIC） for intraoperative evaluation of SLNs.Methods SLNs were sectioned in 1.5-3.0 mm pieces. TIC was performed on all pieces and the BLN Assay and postoperative histology evaluations were performed on different alternating node pieces. Overall performance of the BLN Assay was compared with that of TIC relative to the postoperative histology results.Results A total of 90 patients enrolled in the study. Complete intraoperative data for both the BLN Assay and TIC were collected in 86 patients. The sensitivity, specificity, and overall accuracy of the BLN Assay were 82%, 97%, and 92%,respectively on a per patient basis compared with those of TIC which were 67%, 100%, and 90%.Conclusions Performance of the BLN Assay was superior to that of TIC and the additional application of TIC did not help improve the total sensitivity and accuracy of the intraoperative assessment. The existence of ectopic breast tissue might be a possible cause of false positive for the BLN assay. In addition, the BLN Assay complements histopathology assessment and can minimize sampling error without increasing pathologists＇ workload.
文摘Background Three randomised trials have demonstrated that combining bevacizumab with first-line chemotherapy significantly improves progression-free survival versus chemotherapy alone in HER2-negative locally recurrent/metastatic breast cancer （LR/mBC）. However, data from Chinese populations are limited and possible differences between ethnic and geographic populations are unknown. This study was conducted to determine whether there are differences in safety and efficacy in patients with HER2-negative LR/mRC between Chinese and Western populations after they receive first-line bevacizumab combined with taxane-based therapy.
文摘Background Seroma formation is one of the most common complications after breast cancer surgery. Various risk factors have been evaluated for their associations with the development of seromas in Western populations. However, similar data are not available in Chinese series. Therefore, we sought to investigate the potential risk factors for Chinese breast cancer patients. Methods A prospective study of female breast cancer patients undergoing surgery was carried out in Cancer Hospital of Fudan Unversity, Shanghai, China. Univariate analyses were performed by chi-square test or Student＇s t test or Mann-Whitney test and multivariate analyses by stepwise Logistic regression. The logistic model included age （years）, total serum protein concentration （g/L）, drainage volume on postoperative day 3 （POD 3; ml） and time to daily drainage volume not more than 30 ml （TTV30; days）. Results A total of 158 patients with breast cancer were studied. The mean age at diagnosis was （52.14±10.77） years （range 25-92）. During the follow-up period, 24 （15.2%） patients developed seromas. Calculated as continuous variables in the stepwise Logistic regression, age （0R=1.090, 95% CI 1.028-1.155, P=0.004）, total serum protein concentration （OR=0.886, 95% Cl 0.791-0.992, P=0.036）, drainage volume on POD3 （OR=1.013, 95% Cl 1.002-1.023, P=0.017） and TTV30 （OR=1.273, 95% CI 1.039-1.561, P=0.020） were independent risk factors for seroma formation. Additionally, significant difference in daily drainage volume was substantiated in the analysis by seroma formation （P=0.034） rather than by type of surgery （P=0.713）. Conclusions Although the pathogenesis of seroma remains controversial, such risk factors as age, nutritional status, drainage volume on POD3 and TTV30 should be considered for prediction and prevention of seroma formation in Chinese breast cancer patients.
