A Novel Photocleaver with Long Wavelength Absorption-Highly Efficient Antitumor Agent: 4-(2-Diethylamino-ethylamino)-8-oxo-8H-acenaphtho-[1,2-b]pyrrole-9-carbonitrile

The photocleavage abilities of a novel family of compounds, 8-oxo-8%H%-acenaphtho pyrrole-9-carbonitrile and its derivatives(compounds 1—5) were evaluated with M13 mp18 single strand circular DNA. Only compound 1 with a diethylamine group could bind to DNA %via% electrostatic attraction and intercalation. At a concentration of 50 μmol/L, it could generate singlet oxygen to cleave circular DNA into linear DNA under the irradiation of long wavelength light(λ>400 nm). The antitumor {ability} of compound 1 was also evaluated in vitro, and its IC_ 50 on HeLa cells was as low as 6.8 μmol/L.

慈悲心 家国情——传承南岳佛道救难协会爱国精神

南岳是中华五岳之一,素有“五岳独秀”、“中华寿岳”之称.自然景观丰富,人文底蕴深厚,既是宗教名山,也是文化名山。从传说中的三皇五帝时代直到明清,南岳历来都是国家祭祀祈福的重镇。康熙年间的《御制重修南岳庙碑记》载:“南岳为天南巨镇,上应北斗玉衡,亦名寿现,主灵长禄位,绵福祚于子孙。载在星经,由来尚已。”也正因为此,历史上的岳神祭祀大典不仅是地方性的宗教活动,更是国家大事。直到今天,南岳大庙等处还供奉着以祝融为主神的南岳圣帝,香火不断。