The crisis in Ukraine,which has dragged on for more than two years,and whether military aid to Ukraine should continue are major issues debated and fought over by the two parties in the United States prior to the 2024...The crisis in Ukraine,which has dragged on for more than two years,and whether military aid to Ukraine should continue are major issues debated and fought over by the two parties in the United States prior to the 2024 election.Regarding whether to continue to aid Ukraine,various political forces in the United States have chosen sides in the election campaign,which can be roughly divided into the“aid camp”and the“stop-aid camp”according to their positions.展开更多
Small interfering RNA(siRNA) has been proved to be a powerful tool for silencing target gene in cells, raising the possibility that siRNA can be employed as a therapy for treating cancers and other genetic diseases. H...Small interfering RNA(siRNA) has been proved to be a powerful tool for silencing target gene in cells, raising the possibility that siRNA can be employed as a therapy for treating cancers and other genetic diseases. However, siRNA transfection has the limitation due to the difficulty in the delivery of siRNA to target cells and tissues. To explore an efficient biocompatible siRNA delivery system, cationic diphenylalanine vesicles(CDPVs) were constructed to transfer survivin siRNA to human ovarian cancer cells. The morphology of CDPVs was characterized by scanning electron microscopy(SEM) and the distribution of survivin siRNA was characterized by confocal laser scanning microscopy, which reveal that diphenylalanine and the survivin siRNA were successfully co-delivered. After co-incubation for 48 h, the CDPVs/siRNA exhibited enhanced tumor cell growth inhabitation and apoptosis inducted in human SK-OV-3 ovarian carcinoma cells. Overall, CDPVs is an efficient siRNA delivery system and has a promising prospect for cancer therapy.展开更多
文摘The crisis in Ukraine,which has dragged on for more than two years,and whether military aid to Ukraine should continue are major issues debated and fought over by the two parties in the United States prior to the 2024 election.Regarding whether to continue to aid Ukraine,various political forces in the United States have chosen sides in the election campaign,which can be roughly divided into the“aid camp”and the“stop-aid camp”according to their positions.
文摘Small interfering RNA(siRNA) has been proved to be a powerful tool for silencing target gene in cells, raising the possibility that siRNA can be employed as a therapy for treating cancers and other genetic diseases. However, siRNA transfection has the limitation due to the difficulty in the delivery of siRNA to target cells and tissues. To explore an efficient biocompatible siRNA delivery system, cationic diphenylalanine vesicles(CDPVs) were constructed to transfer survivin siRNA to human ovarian cancer cells. The morphology of CDPVs was characterized by scanning electron microscopy(SEM) and the distribution of survivin siRNA was characterized by confocal laser scanning microscopy, which reveal that diphenylalanine and the survivin siRNA were successfully co-delivered. After co-incubation for 48 h, the CDPVs/siRNA exhibited enhanced tumor cell growth inhabitation and apoptosis inducted in human SK-OV-3 ovarian carcinoma cells. Overall, CDPVs is an efficient siRNA delivery system and has a promising prospect for cancer therapy.
