【目的】比较两种酵母培养物及其代谢成分的差异,为指导酵母培养物的生产及应用提供参考。【方法】材料为1种自研酵母培养物与达农威益康XP酵母培养物,利用非靶标代谢组学UHPLC-QTOF-MS技术,分析比较二者代谢产物成分及差异。【结果】(1...【目的】比较两种酵母培养物及其代谢成分的差异,为指导酵母培养物的生产及应用提供参考。【方法】材料为1种自研酵母培养物与达农威益康XP酵母培养物,利用非靶标代谢组学UHPLC-QTOF-MS技术,分析比较二者代谢产物成分及差异。【结果】(1)在二级类别注释下,正、负离子模式分别注释到614、497个化合物,主要代谢类别为有机酸,核苷、核苷酸及其衍生物,氨基酸及其衍生物,两种酵母培养物均无特有代谢成分,只在含量上有显著(P<0.05)差异。(2)共237个差异代谢物在正离子模式检出,176个显著(P<0.05)上调表达,61个显著(P<0.05)下调表达;136个差异代谢物在负离子模式检出,64个显著(P<0.05)上调表达,72个显著(P<0.05)下调表达。(3)差异代谢物的KEGG(Kyoto Encyclopedia of Genes and Genomes)富集分析主要集中在丙氨酸、天冬氨酸和谷氨酸等代谢通路。【结论】自研酵母培养物与达农威益康XP的代谢产物含量存在显著差异,但其发酵原料及工艺更简便,并含有多种具药理、生理作用的代谢成分,有潜在应用价值。展开更多
City cluster is an effective platform for encouraging regionally coordinated development.Coordinated reduction of carbon emissions within city cluster via the spatial association network between cities can help coordi...City cluster is an effective platform for encouraging regionally coordinated development.Coordinated reduction of carbon emissions within city cluster via the spatial association network between cities can help coordinate the regional carbon emission management,realize sustainable development,and assist China in achieving the carbon peaking and carbon neutrality goals.This paper applies the improved gravity model and social network analysis(SNA)to the study of spatial correlation of carbon emissions in city clusters and analyzes the structural characteristics of the spatial correlation network of carbon emissions in the Yangtze River Delta(YRD)city cluster in China and its influencing factors.The results demonstrate that:1)the spatial association of carbon emissions in the YRD city cluster exhibits a typical and complex multi-threaded network structure.The network association number and density show an upward trend,indicating closer spatial association between cities,but their values remain generally low.Meanwhile,the network hierarchy and network efficiency show a downward trend but remain high.2)The spatial association network of carbon emissions in the YRD city cluster shows an obvious‘core-edge’distribution pattern.The network is centered around Shanghai,Suzhou and Wuxi,all of which play the role of‘bridges’,while cities such as Zhoushan,Ma'anshan,Tongling and other cities characterized by the remote location,single transportation mode or lower economic level are positioned at the edge of the network.3)Geographic proximity,varying levels of economic development,different industrial structures,degrees of urbanization,levels of technological innovation,energy intensities and environmental regulation are important influencing factors on the spatial association of within the YRD city cluster.Finally,policy implications are provided from four aspects:government macro-control and market mechanism guidance,structural characteristics of the‘core-edge’network,reconfiguration and optimization of the spatial layout of the YRD city cluster,and the application of advanced technologies.展开更多
目的研究甲状腺结节(thyroid imaging reporting and data system,TI-RADS)分级与代谢相关指标的关系。方法非随机选取伊犁哈萨克自治州中医医院于2022年1月—2023年1月期间收治的150例甲状腺结节检出患者为研究对象,经TI-RADS分级分为T...目的研究甲状腺结节(thyroid imaging reporting and data system,TI-RADS)分级与代谢相关指标的关系。方法非随机选取伊犁哈萨克自治州中医医院于2022年1月—2023年1月期间收治的150例甲状腺结节检出患者为研究对象,经TI-RADS分级分为TI-RADS 3类及以下者(良性组)51例、TI-RADS 4a类(低度恶性组)50例、TI-RADS 4b类及以上组(恶性组)49例,对比3组患者代谢相关指标水平差异,并分析相关性。结果3组患者总胆固醇、甘油三酯、高密度脂蛋白、HOMA胰岛素抵抗指数、餐后2 h血糖比较,差异无统计学意义(P均>0.05);3组患者低密度脂蛋白(low-density lipoprotein,LDL-C)、糖化血红蛋白(glycosylatedhemoglobin,HbA1c)、空腹血糖(fastingplasmaglucose,FPG)、抗甲状腺球蛋白抗体(antithyroglobulin anti-bodies,TGAb)、体重指数(body mass index,BMI)水平比较,差异有统计学意义(P均<0.05)。Pearson相关分析结果显示,甲状腺结节TI-RADS分级与LDL-C、HbA1c、FPG、TGAb水平之间呈现正相关(r=1.334、0.092、0.193、1.294,P均<0.05),甲状腺结节TI-RADS分级BMI水平之间呈现负相关(r=-0.092,P<0.05)。结论代谢相关指标与甲状腺结节的TI-RADS分级之间存在联系,高级别结节患者在BMI、LDL-C、HbA1c、FPG、TGAb指标方面表现出异常。展开更多
文摘【目的】比较两种酵母培养物及其代谢成分的差异,为指导酵母培养物的生产及应用提供参考。【方法】材料为1种自研酵母培养物与达农威益康XP酵母培养物,利用非靶标代谢组学UHPLC-QTOF-MS技术,分析比较二者代谢产物成分及差异。【结果】(1)在二级类别注释下,正、负离子模式分别注释到614、497个化合物,主要代谢类别为有机酸,核苷、核苷酸及其衍生物,氨基酸及其衍生物,两种酵母培养物均无特有代谢成分,只在含量上有显著(P<0.05)差异。(2)共237个差异代谢物在正离子模式检出,176个显著(P<0.05)上调表达,61个显著(P<0.05)下调表达;136个差异代谢物在负离子模式检出,64个显著(P<0.05)上调表达,72个显著(P<0.05)下调表达。(3)差异代谢物的KEGG(Kyoto Encyclopedia of Genes and Genomes)富集分析主要集中在丙氨酸、天冬氨酸和谷氨酸等代谢通路。【结论】自研酵母培养物与达农威益康XP的代谢产物含量存在显著差异,但其发酵原料及工艺更简便,并含有多种具药理、生理作用的代谢成分,有潜在应用价值。
基金Under the auspices of the National Natural Science Foundation of China (No.72273151)。
文摘City cluster is an effective platform for encouraging regionally coordinated development.Coordinated reduction of carbon emissions within city cluster via the spatial association network between cities can help coordinate the regional carbon emission management,realize sustainable development,and assist China in achieving the carbon peaking and carbon neutrality goals.This paper applies the improved gravity model and social network analysis(SNA)to the study of spatial correlation of carbon emissions in city clusters and analyzes the structural characteristics of the spatial correlation network of carbon emissions in the Yangtze River Delta(YRD)city cluster in China and its influencing factors.The results demonstrate that:1)the spatial association of carbon emissions in the YRD city cluster exhibits a typical and complex multi-threaded network structure.The network association number and density show an upward trend,indicating closer spatial association between cities,but their values remain generally low.Meanwhile,the network hierarchy and network efficiency show a downward trend but remain high.2)The spatial association network of carbon emissions in the YRD city cluster shows an obvious‘core-edge’distribution pattern.The network is centered around Shanghai,Suzhou and Wuxi,all of which play the role of‘bridges’,while cities such as Zhoushan,Ma'anshan,Tongling and other cities characterized by the remote location,single transportation mode or lower economic level are positioned at the edge of the network.3)Geographic proximity,varying levels of economic development,different industrial structures,degrees of urbanization,levels of technological innovation,energy intensities and environmental regulation are important influencing factors on the spatial association of within the YRD city cluster.Finally,policy implications are provided from four aspects:government macro-control and market mechanism guidance,structural characteristics of the‘core-edge’network,reconfiguration and optimization of the spatial layout of the YRD city cluster,and the application of advanced technologies.
文摘目的研究甲状腺结节(thyroid imaging reporting and data system,TI-RADS)分级与代谢相关指标的关系。方法非随机选取伊犁哈萨克自治州中医医院于2022年1月—2023年1月期间收治的150例甲状腺结节检出患者为研究对象,经TI-RADS分级分为TI-RADS 3类及以下者(良性组)51例、TI-RADS 4a类(低度恶性组)50例、TI-RADS 4b类及以上组(恶性组)49例,对比3组患者代谢相关指标水平差异,并分析相关性。结果3组患者总胆固醇、甘油三酯、高密度脂蛋白、HOMA胰岛素抵抗指数、餐后2 h血糖比较,差异无统计学意义(P均>0.05);3组患者低密度脂蛋白(low-density lipoprotein,LDL-C)、糖化血红蛋白(glycosylatedhemoglobin,HbA1c)、空腹血糖(fastingplasmaglucose,FPG)、抗甲状腺球蛋白抗体(antithyroglobulin anti-bodies,TGAb)、体重指数(body mass index,BMI)水平比较,差异有统计学意义(P均<0.05)。Pearson相关分析结果显示,甲状腺结节TI-RADS分级与LDL-C、HbA1c、FPG、TGAb水平之间呈现正相关(r=1.334、0.092、0.193、1.294,P均<0.05),甲状腺结节TI-RADS分级BMI水平之间呈现负相关(r=-0.092,P<0.05)。结论代谢相关指标与甲状腺结节的TI-RADS分级之间存在联系,高级别结节患者在BMI、LDL-C、HbA1c、FPG、TGAb指标方面表现出异常。
