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栀子苷改善糖尿病肾病小鼠肾功能的作用 被引量:4
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作者 戴标 施丽丹 +1 位作者 谢鸣部 占洪斌 《解剖学研究》 CAS 2023年第1期40-45,共6页
目的 研究栀子苷对糖尿病肾病小鼠(DN)肾的功能和作用机制。方法 30只小鼠在适应性饲养后随机分为正常组(ND)、糖尿病肾病模型组(DN)和栀子苷组(DN+Geniposide),每组10只。模型以高脂饲料喂养并结合链脲佐霉素(STZ)构建小鼠糖尿病肾病(... 目的 研究栀子苷对糖尿病肾病小鼠(DN)肾的功能和作用机制。方法 30只小鼠在适应性饲养后随机分为正常组(ND)、糖尿病肾病模型组(DN)和栀子苷组(DN+Geniposide),每组10只。模型以高脂饲料喂养并结合链脲佐霉素(STZ)构建小鼠糖尿病肾病(DN)模型,ND组小鼠使用普通饲料喂养并给予等量的0.9%的氯化钠注射液。实验过程中记录小鼠体质量和空腹血糖变化;药物治疗后检测小鼠血糖耐量的变化,肾功能指标UAER、BUN和CR的变化;苏木精-伊红(HE)染色观察小鼠肾的病理变化;使用ELISA试剂盒检测小鼠肾组织中TNF-α、IL-6和IL-1β炎症因子指标;WB实验检测小鼠肾组织中TLR4和TGF-β1蛋白的表达。结果 与ND组相比,DN组小鼠后期体重出现降低,空腹血糖值升高;染色结果显示小鼠肾组织明显损伤;ELISA检测的指标UAER、BUN、CR、TNF-α、IL-6和IL-1β表达明显上升;蛋白水平的TLR4和TGF-β1表达升高,而栀子苷能有效恢复这些指标的表达水平,其组间差异有统计学意义(P<0.05或P<0.01)。结论 栀子苷有效降低小鼠DN模型的炎症反应,调控细胞分化和生长,保护模型小鼠的肾功能。 展开更多
关键词 栀子苷 糖尿病肾病 肾功能 炎症 TLR4/TGF-β1
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Exploration and Reflection on College Online English Teaching in Henan Police College
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作者 shi li-dan 《Journal of Literature and Art Studies》 2021年第10期794-800,共7页
Under the background of the Internet Plus,the research on the online and offline integrated teaching mode is particularly important.Therefore,based on the teaching of Henan Police College and taking the college Englis... Under the background of the Internet Plus,the research on the online and offline integrated teaching mode is particularly important.Therefore,based on the teaching of Henan Police College and taking the college English course as an example,this paper investigates and analyzes the online teaching situation.The results show that there are significant differences between gender and grade in students’online English learning;the biggest difficulty for students in online English learning is the lack of learning materials like textbooks and the simultaneous use of multiple equipment in class;the biggest problem in the ideological and political integration of English course is that the way of ideological and political integration in English class lacks of variety.Through this research,it is hoped to help teachers in HNP college improve the online teaching mode,improve the online teaching quality,and promote the normalization of online and offline teaching mode. 展开更多
关键词 online and offline integrated teaching mode online English learning new normal
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