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大跨度不对称连续刚构桥的静动力行为研究
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作者 石晓建 刘建武 《建筑机械》 2024年第10期134-140,共7页
在山区修建连续刚构桥时,受制于山区地形,往往采用非对称布置的桥梁方案,但其静动力特性复杂。文章以某(83+180+105)m不对称连续刚构桥为工程背景,重点从体外束、结构敏感性和合龙顶推力3方面讨论了桥梁的静力行为,并进行了抗震分析研... 在山区修建连续刚构桥时,受制于山区地形,往往采用非对称布置的桥梁方案,但其静动力特性复杂。文章以某(83+180+105)m不对称连续刚构桥为工程背景,重点从体外束、结构敏感性和合龙顶推力3方面讨论了桥梁的静力行为,并进行了抗震分析研究。结果表明:施加体外束能增加结构的抗裂性和提高安全储备;结构设计对箱梁超重、铺装超厚和纵向预应力张拉力减少的变化均比较敏感,对主梁的抗裂影响较大;合理提高跨中合龙时的顶推力可以抵消高温合龙和混凝土容重提高带来的不利影响;在E2地震作用下,桩基顶部以下6m范围发生屈服,在设置永久性钢护筒后,墩柱和桩基均未出现塑性铰,满足相关规范要求。 展开更多
关键词 大跨度 不对称连续刚构 静动力行为 数值计算
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浅谈奖学金在高校育人工作中的激励作用——以北京化工大学奖学励志德育创新基地为例 被引量:1
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作者 张雪祯 史晓健 李承明 《教育教学论坛》 2017年第15期60-61,共2页
奖学金工作作为资助体系的重要部分,对获奖学生和广大学生群体有着重要的激励作用。本文以北京化工大学奖学励志德育创新基地为例,介绍创新奖学金评定办法的优化探索及如何借助奖学金评定开展感恩教育的相关做法。
关键词 奖学金 德育创新基地 感恩教育 能力提升
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β-catenin expression pattern in primary oral squamous cell carcinoma 被引量:2
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作者 CAI Zhi-gang shi xiao-jian +3 位作者 GAO Yan WEI Ming-jie WANG Cun-yu YU Guang-yan 《Chinese Medical Journal》 SCIE CAS CSCD 2008年第19期1866-1870,共5页
Background β--catenin, a 92 kDa protein that binds to the cytoplasmic tail of E-cadherin, has an essential role in intercellular adhesion and signal transduction. Aberrant expression of β-catenin has been associated... Background β--catenin, a 92 kDa protein that binds to the cytoplasmic tail of E-cadherin, has an essential role in intercellular adhesion and signal transduction. Aberrant expression of β-catenin has been associated with progression and metastasis of various human cancers. The aim of this study was to elucidate the expression pattern of β-catenin in primary oral squamous cell carcinoma and examine the correlation between β-catenin expression and tumor differentiation, histological grade and lymph node status as well as its clinical significances. Methods Seventy-six patients with oral squamous cell carcinoma and sixteen metastatic lymph nodes were studied. The β-catenin expression was determined by immunohistochemical staining. The correlation with clinical, histological data was analyzed statistically. Results Normal oral epithelium showed strong β-catenin expression at the cell membrane, but no cytoplasmic or nuclear expression. Different degrees of reduced expression of β-catenin at the cell membrane were found in 54 cases with squamous cell carcinoma (71%). Cytoplasmic β-catenin expression was found in 17 tumors (22.4%). Three cases were found with nuclear β-catenin expression. In sixteen lymph nodes with metastatic squamous cell carcinoma, negative β-catenin expression at the cell membrane was seen in 13 tumors (81.2%) and weak expression in 3 tumors (18.8%). Statistical analysis showed that there was an inverse correlation between β-catenin expression and lymph node status and histological grade of tumors. Conclusions Reduced β-catenin expression at the cell membrane is clearly associated with lymph node metastasis. A reduced expression of β-catenin may constitute a hallmark of aggressive biological behavior of squamous cell carcinoma. 展开更多
关键词 Β-CATENIN squamous cell carcinoma immunohistochemical staining
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