Allergic asthma is currently considered a chronic airway inflammatory disorder associated with the presence of activated CD_4^+ Th2-type lymphocytes, eosinophils, and mast cells. Interestingly, therapeutic strategies ...Allergic asthma is currently considered a chronic airway inflammatory disorder associated with the presence of activated CD_4^+ Th2-type lymphocytes, eosinophils, and mast cells. Interestingly, therapeutic strategies based on immune deviation and suppression have been shown to successfully attenuate the development of the asthma phenotype. Despite the clear rational for immunotherapy, the usefulness of this approach has been limited by the potential for adverse effects, particularly anaphylaxis, and the relatively crude nature of the allergen extracts that are available. To overcome these problems, revised strategies have been assessed in animals展开更多
文摘Allergic asthma is currently considered a chronic airway inflammatory disorder associated with the presence of activated CD_4^+ Th2-type lymphocytes, eosinophils, and mast cells. Interestingly, therapeutic strategies based on immune deviation and suppression have been shown to successfully attenuate the development of the asthma phenotype. Despite the clear rational for immunotherapy, the usefulness of this approach has been limited by the potential for adverse effects, particularly anaphylaxis, and the relatively crude nature of the allergen extracts that are available. To overcome these problems, revised strategies have been assessed in animals
