The secondary structures of native cytochrome c(cyt c) in both solid and solution states and four platinum modified cyt c derivatives in solution were determined by means of Fourier transform infrared spectroscopy. I...The secondary structures of native cytochrome c(cyt c) in both solid and solution states and four platinum modified cyt c derivatives in solution were determined by means of Fourier transform infrared spectroscopy. It was found that the secondary structure of cyt c in solid state is similar to that in the solution. In the cases of platinum modified cyt c derivatives, when the binding sites of platinum complex are on or near the surface of the protein, its secondary structure is similar to that of native cyt c. However, when the platinum complex binds to Met 80 ligand and causes the replacement of the second axial ligand by non native Lys 79 ligand or H 2O supplied by solvent, there is a significant difference between the structures of low or high spin state cyt c derivatives and that of native cyt c. The results suggest that axial ligand Met 80 residue plays an important role in stabilizing the secondary structure of cyt c.展开更多
A pair of enatiomerically pure ligands,(R-)/(S-)2-(4-carboxyphenyl)-4,5-dihydrothiazole-4-carboxylic acid(H2L^R & H2L^S), have been synthesized by the reactions of 4-cyanobenzoic acid with L-and D-cysteine, respec...A pair of enatiomerically pure ligands,(R-)/(S-)2-(4-carboxyphenyl)-4,5-dihydrothiazole-4-carboxylic acid(H2L^R & H2L^S), have been synthesized by the reactions of 4-cyanobenzoic acid with L-and D-cysteine, respectively. Four coordination polymers have been prepared from the ligands and structurally determined by single-crystal X-ray diffraction analysis. Complexes 1 R and 1 S([NiL(Py)(H2 O)]×H2 O, for 1 R, L =(L^R)^(2-);for 1 S, L =(L^S)^(2-)) exhibit chiral helical one-dimensional chains, and complexes 2 R and 2 S({[ZnL2(H2 O)3]×CH3 CN}n, for 2 R L =(L^R)^(2-), for 2 S L =(LS)^(2-)) are two-dimensional sheets. Luminescent and chir-optical properties have been investigated and compared with the free ligands. The complexes have blue-shift in luminescence spectrum compared with the free ligands.展开更多
The preparation method of a funnel like ligand derived from calix[6]arene and tris(2-pyridyl-methyl)anime has been improved.The Cu(Ⅱ)complex was obtained and characterized by ESI-MS,EPR,UV-Vis spectra and crystallogr...The preparation method of a funnel like ligand derived from calix[6]arene and tris(2-pyridyl-methyl)anime has been improved.The Cu(Ⅱ)complex was obtained and characterized by ESI-MS,EPR,UV-Vis spectra and crystallographic analysis.In the complex,a guest acetonitrile molecule is introduced into the cavity of the ligand host via the coordination with Cu(Ⅱ)center.展开更多
文摘The secondary structures of native cytochrome c(cyt c) in both solid and solution states and four platinum modified cyt c derivatives in solution were determined by means of Fourier transform infrared spectroscopy. It was found that the secondary structure of cyt c in solid state is similar to that in the solution. In the cases of platinum modified cyt c derivatives, when the binding sites of platinum complex are on or near the surface of the protein, its secondary structure is similar to that of native cyt c. However, when the platinum complex binds to Met 80 ligand and causes the replacement of the second axial ligand by non native Lys 79 ligand or H 2O supplied by solvent, there is a significant difference between the structures of low or high spin state cyt c derivatives and that of native cyt c. The results suggest that axial ligand Met 80 residue plays an important role in stabilizing the secondary structure of cyt c.
基金supported by the National Natural Science Foundation of China(No.21271129)。
文摘A pair of enatiomerically pure ligands,(R-)/(S-)2-(4-carboxyphenyl)-4,5-dihydrothiazole-4-carboxylic acid(H2L^R & H2L^S), have been synthesized by the reactions of 4-cyanobenzoic acid with L-and D-cysteine, respectively. Four coordination polymers have been prepared from the ligands and structurally determined by single-crystal X-ray diffraction analysis. Complexes 1 R and 1 S([NiL(Py)(H2 O)]×H2 O, for 1 R, L =(L^R)^(2-);for 1 S, L =(L^S)^(2-)) exhibit chiral helical one-dimensional chains, and complexes 2 R and 2 S({[ZnL2(H2 O)3]×CH3 CN}n, for 2 R L =(L^R)^(2-), for 2 S L =(LS)^(2-)) are two-dimensional sheets. Luminescent and chir-optical properties have been investigated and compared with the free ligands. The complexes have blue-shift in luminescence spectrum compared with the free ligands.
基金Financial support from the Natural Science Foundation of Shanghai (No. 19ZR1424900)
文摘The preparation method of a funnel like ligand derived from calix[6]arene and tris(2-pyridyl-methyl)anime has been improved.The Cu(Ⅱ)complex was obtained and characterized by ESI-MS,EPR,UV-Vis spectra and crystallographic analysis.In the complex,a guest acetonitrile molecule is introduced into the cavity of the ligand host via the coordination with Cu(Ⅱ)center.
