Background:Ferroptosis,a lipid peroxidation-mediated programmed cell death,is closely linked to tumor development,including prostate cancer(PCa).Despite established connections between ferroptosis and PCa,a comprehens...Background:Ferroptosis,a lipid peroxidation-mediated programmed cell death,is closely linked to tumor development,including prostate cancer(PCa).Despite established connections between ferroptosis and PCa,a comprehensive investigation is essential for understanding its impact on patient prognosis.Methods:A risk model incorporating four ferroptosis-related genes was developed and validated.Elevated risk scores correlated with an increased likelihood of biochemical recurrence(BCR),diminished immune infiltration,and adverse clinicopathological characteristics.To corroborate these results,we performed validation analyses utilizing datasets from both the Cancer Genome Atlas Cohort(TCGA)and the Gene Expression Synthesis Cohort(GEO).Moreover,we conducted further investigations into the pivotal gene identified in our model to explore its impact on tumor characteristics through cell proliferation and invasion assays,as well as animal studies conducted in vivo.Additionally,we conducted further experiments involving ferroptosis-related analysis to validate its association with ferroptosis.Results:The risk model demonstrated exceptional predictive capabilities for prognosis and therapeutic outcomes in PCa patients.Mitogen-activated protein kinase 9(MAPK9)emerged as a crucial gene within the model.In vivo and in vitro experiments explored MAPK9’s role in ferroptosis and its influence on tumor migration and proliferation.Conclusion:The findings provide a novel perspective for advancing ferroptosis exploration in PCa,bridging basic research and clinical applications.展开更多
The fine-grained uncertainty relation (FUR) is investigated for accelerating open quantum system, which manifests the celebrated Unruh effect, a crucial piece of the jigsaw for combining relativity and quantum physics...The fine-grained uncertainty relation (FUR) is investigated for accelerating open quantum system, which manifests the celebrated Unruh effect, a crucial piece of the jigsaw for combining relativity and quantum physics. For a single detector, we show that the inevitable Unruh decoherence can induce a smaller FUR uncertainty bound, which indicates an additional measurement uncertainty may exist. For an open system combined with two detectors, via a nonlocal retrieval game, the related FUR uncertainty bound is determined by the non-classical correlation of the system. By estimating the maximal violation of Bell inequality for an accelerating system, we show that the FUR uncertainty bound can be protected from Unruh decoherence, due to quantum correlation generated through Markovian dynamics.展开更多
文摘Background:Ferroptosis,a lipid peroxidation-mediated programmed cell death,is closely linked to tumor development,including prostate cancer(PCa).Despite established connections between ferroptosis and PCa,a comprehensive investigation is essential for understanding its impact on patient prognosis.Methods:A risk model incorporating four ferroptosis-related genes was developed and validated.Elevated risk scores correlated with an increased likelihood of biochemical recurrence(BCR),diminished immune infiltration,and adverse clinicopathological characteristics.To corroborate these results,we performed validation analyses utilizing datasets from both the Cancer Genome Atlas Cohort(TCGA)and the Gene Expression Synthesis Cohort(GEO).Moreover,we conducted further investigations into the pivotal gene identified in our model to explore its impact on tumor characteristics through cell proliferation and invasion assays,as well as animal studies conducted in vivo.Additionally,we conducted further experiments involving ferroptosis-related analysis to validate its association with ferroptosis.Results:The risk model demonstrated exceptional predictive capabilities for prognosis and therapeutic outcomes in PCa patients.Mitogen-activated protein kinase 9(MAPK9)emerged as a crucial gene within the model.In vivo and in vitro experiments explored MAPK9’s role in ferroptosis and its influence on tumor migration and proliferation.Conclusion:The findings provide a novel perspective for advancing ferroptosis exploration in PCa,bridging basic research and clinical applications.
基金Project supported by the National Natural Science Foundation of China(Grant No.12075178)the Natural Science Basic Research Plan in Shaanxi Province of China(Grant No.2018JM1049).
文摘The fine-grained uncertainty relation (FUR) is investigated for accelerating open quantum system, which manifests the celebrated Unruh effect, a crucial piece of the jigsaw for combining relativity and quantum physics. For a single detector, we show that the inevitable Unruh decoherence can induce a smaller FUR uncertainty bound, which indicates an additional measurement uncertainty may exist. For an open system combined with two detectors, via a nonlocal retrieval game, the related FUR uncertainty bound is determined by the non-classical correlation of the system. By estimating the maximal violation of Bell inequality for an accelerating system, we show that the FUR uncertainty bound can be protected from Unruh decoherence, due to quantum correlation generated through Markovian dynamics.
