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High-resolution mid-infrared single-photon upconversion ranging
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作者 shuhong jiang KUN HUANG +7 位作者 TINGTING YU JIANAN FANG BEN SUN YAN LIANG QIANG HAO E.WU MING YAN HEPING ZENG 《Photonics Research》 SCIE EI CAS CSCD 2024年第6期1294-1302,共9页
Single-photon laser ranging has widespread applications in remote sensing and target recognition.However,highly sensitive light detection and ranging(lidar)has long been restricted in the visible or near-infrared band... Single-photon laser ranging has widespread applications in remote sensing and target recognition.However,highly sensitive light detection and ranging(lidar)has long been restricted in the visible or near-infrared bands.An appealing quest is to extend the operation wavelength into the mid-infrared(MIR)region,which calls for an infrared photon-counting system at high detection sensitivity and precise temporal resolution.Here,we devise and demonstrate an MIR upconversion lidar based on nonlinear asynchronous optical sampling.Specifically,the infrared probe is interrogated in a nonlinear crystal by a train of pump pulses at a slightly different repetition rate,which favors temporal optical scanning at a picosecond timing resolution and a kilohertz refreshing rate over-50ns.Moreover,the cross-correlation upconversion trace is temporally stretched by a factor of 2×10^(4),which can thus be recorded by a low-bandwidth silicon detector.In combination with the time-correlated photon-counting technique,the achieved effective resolution is about two orders of magnitude better than the timing jitter of the detector itself,which facilitates a ranging precision of 4μm under a low detected flux of 8×10^(−5) photons per pulse.The presented MIR time-of-flight range finder is featured with single-photon sensitivity and high positioning resolution,which would be particularly useful in infrared sensing and imaging in photon-starved scenarios. 展开更多
关键词 resolution lidar REPETITION
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幼年特发性关节炎患儿白内障术后眼内炎症与血清细胞因子的关系 被引量:3
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作者 马晓程 邢怡桥 +1 位作者 姜淑红 崔巍 《中华眼视光学与视觉科学杂志》 CAS CSCD 2019年第11期813-819,共7页
目的:探讨Th17、Th1和调节性T细胞相关促炎细胞因子在幼年特发性关节炎(JIA)患儿白内障术后眼内炎症反应中的作用。方法:回顾性病例对照研究。收集2013年7月至2018年3月于内蒙古自治区人民医院眼科就诊的32例JIA患儿(JIA组)和35例先天... 目的:探讨Th17、Th1和调节性T细胞相关促炎细胞因子在幼年特发性关节炎(JIA)患儿白内障术后眼内炎症反应中的作用。方法:回顾性病例对照研究。收集2013年7月至2018年3月于内蒙古自治区人民医院眼科就诊的32例JIA患儿(JIA组)和35例先天性白内障患儿(先天性白内障组)在白内障手术前及术后1、7、30、90 d的血清以及手术开始时的房水。采用多组别免疫分析系统测定血清和房水中白细胞介素-1β(IL-1β)、IL-6、IL-10、IL-23、IL-27、IL-17和干扰素-γ(IFN-γ)的蛋白水平。激光蛋白细胞检测仪用于定量眼内炎症。采用重复测量方差分析对数据进行统计学分析,用Spearman相关系数法计算JIA患者血清IL-6、IL-23和IFN-γ水平与房水闪辉值和细胞计数之间的相关性。结果:JIA组术后1 d血清IL-23[(612±190)pg/ml]、IL-6[(305±82)pg/ml]、IFN-γ[(172±43)pg/ml]、IL-10[(202±114)pg/ml]、IL-27[(110±43)pg/ml]和IL-1β[(106±27)pg/ml]均明显升高,术后90 d逐渐恢复至术前水平。JIA组术前及术后1、7、30、90 d血清IL-1β、IL-6、IL-23、IL-27、IL-10和IFN-γ均明显高于先天性白内障组。JIA患者血清的IL-6水平(r=0.085,P=0.002)、IFN-γ水平(r=0.741,P=0.021)、IL-23水平(r=0.622,P=0.028)与房水闪辉值均有相关性,IL-6水平(r=0.729,P=0.006)、IFN-γ水平(r=0.669,P=0.019)与前房细胞数均有相关性,IL-23水平与前房细胞数无明显相关性(r=0.646,P=0.051)。结论:Th17、Th1和调节性T细胞相关促炎细胞因子IL-6和IFN-γ在JIA患儿血清中水平的升高可反映患者眼内炎症活动情况,血清IL-23、IL-10、IL-27和IL-1β的变化也可以用于评估JIA患者白内障术后眼内炎症的情况。 展开更多
关键词 幼年特发性关节炎 葡萄膜炎 炎性 细胞因子 多重流式细胞记录仪 白内障 手术
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