目的:分析江苏省丙型肝炎病毒(hepatitis C virus,HCV)感染患者的病毒基因型分布特点,为进一步研究HCV感染的流行情况和防治策略提供参考依据。方法:选取2020年1月—2021年5月江苏省内苏州、扬州、镇江、徐州和连云港5市共924例HCV感染...目的:分析江苏省丙型肝炎病毒(hepatitis C virus,HCV)感染患者的病毒基因型分布特点,为进一步研究HCV感染的流行情况和防治策略提供参考依据。方法:选取2020年1月—2021年5月江苏省内苏州、扬州、镇江、徐州和连云港5市共924例HCV感染患者的血清样本作为研究材料,对血样进行HCV基因分型检测,分析HCV的病毒基因型分布特点。结果:924例HCV感染患者的年龄主要集中在>50~60岁(293例,占31.71%)、>60~70岁(211例,占22.74%)和>40~50岁(137例,占14.83%)三个年龄段;924例患者的血清样本中共检出8种基因型,其中主要为1b型(697,占75.43%),其次为2a型(152,占16.45%)为主;此外,苏南(即苏州)与苏中(即扬州+镇江)、苏中与苏北(即徐州+连云港)在1b型的分布上均存在显著差异(P<0.05),而苏南、苏中、苏北在2a型的分布上两两间均存在显著差异(P<0.05)。结论:江苏省内HCV感染患者的年龄主要集中在>40~70岁,而病毒的基因型主要为1b型、其次为2a型,临床应持续重视HCV感染特点的调查研究,助力HCV感染的防治。展开更多
Background As shown in previous studies,high brain natriuretic peptide(BNP)is one of common abnormal laboratory test results in some critical patients infected with 2019 novel coronavirus(2019-nCoV),while the role of ...Background As shown in previous studies,high brain natriuretic peptide(BNP)is one of common abnormal laboratory test results in some critical patients infected with 2019 novel coronavirus(2019-nCoV),while the role of BNP in the prognosis of coronavirus disease 2019(COVID-19)is still unknown.This study aims to investigate the effects of the increased BNP value on the outcomes of 2019-nCoV infected patients.Methods Our study initially included patients diagnosed with COVID-19 in Guangzhou Eighth People’s Hospital from January 20 th,2020 to February 24 th.After screening out the participants based on the exclusion criteria,a total of 34 participants were finally enrolled in our research for retrospective analysis.The primary outcome was severe pneumonia defined according to the international guidelines for community-acquired pneumonia.Clinical characteristics and laboratory data were collected from their medical records.Results The best cut-off value of BNP for predicting severe pneumonia was 97.5 pg/mL with the sensitivity for 80%and the specificity for 91.7%.The median age for high BNP level group(>97.5 pg/mL)was 60.5 years(interquartile range:40-80 years).The ratio of males in those patients was 60.0%.Compared with the normal BNP level group,higher temperature(P=0.09),higher values of aspartate aminotransferase(P=0.02),troponin I(P<0.001),C-reactive protein(P<0.001)and myoglobin(P=0.001)as well as lower levels of hemoglobin(P=0.04)and platelet count(P=0.001)were observed in the high BNP group.Multivariable logistic regression demonstrated that 2019-nCoV infected patients with high BNP were more likely to develop severe pneumonia(OR:17.368,P=0.025)and be admitted to the intensive care unit(OR:27.093,P=0.048).Conclusions The increased level of BNP is associated with the undesirable condition and disease aggravation of patients with COVID-19.BNP is expected to be an independent prognostic predictor of clinical outcomes for patients with COVID-19.展开更多
文摘目的:分析江苏省丙型肝炎病毒(hepatitis C virus,HCV)感染患者的病毒基因型分布特点,为进一步研究HCV感染的流行情况和防治策略提供参考依据。方法:选取2020年1月—2021年5月江苏省内苏州、扬州、镇江、徐州和连云港5市共924例HCV感染患者的血清样本作为研究材料,对血样进行HCV基因分型检测,分析HCV的病毒基因型分布特点。结果:924例HCV感染患者的年龄主要集中在>50~60岁(293例,占31.71%)、>60~70岁(211例,占22.74%)和>40~50岁(137例,占14.83%)三个年龄段;924例患者的血清样本中共检出8种基因型,其中主要为1b型(697,占75.43%),其次为2a型(152,占16.45%)为主;此外,苏南(即苏州)与苏中(即扬州+镇江)、苏中与苏北(即徐州+连云港)在1b型的分布上均存在显著差异(P<0.05),而苏南、苏中、苏北在2a型的分布上两两间均存在显著差异(P<0.05)。结论:江苏省内HCV感染患者的年龄主要集中在>40~70岁,而病毒的基因型主要为1b型、其次为2a型,临床应持续重视HCV感染特点的调查研究,助力HCV感染的防治。
文摘Background As shown in previous studies,high brain natriuretic peptide(BNP)is one of common abnormal laboratory test results in some critical patients infected with 2019 novel coronavirus(2019-nCoV),while the role of BNP in the prognosis of coronavirus disease 2019(COVID-19)is still unknown.This study aims to investigate the effects of the increased BNP value on the outcomes of 2019-nCoV infected patients.Methods Our study initially included patients diagnosed with COVID-19 in Guangzhou Eighth People’s Hospital from January 20 th,2020 to February 24 th.After screening out the participants based on the exclusion criteria,a total of 34 participants were finally enrolled in our research for retrospective analysis.The primary outcome was severe pneumonia defined according to the international guidelines for community-acquired pneumonia.Clinical characteristics and laboratory data were collected from their medical records.Results The best cut-off value of BNP for predicting severe pneumonia was 97.5 pg/mL with the sensitivity for 80%and the specificity for 91.7%.The median age for high BNP level group(>97.5 pg/mL)was 60.5 years(interquartile range:40-80 years).The ratio of males in those patients was 60.0%.Compared with the normal BNP level group,higher temperature(P=0.09),higher values of aspartate aminotransferase(P=0.02),troponin I(P<0.001),C-reactive protein(P<0.001)and myoglobin(P=0.001)as well as lower levels of hemoglobin(P=0.04)and platelet count(P=0.001)were observed in the high BNP group.Multivariable logistic regression demonstrated that 2019-nCoV infected patients with high BNP were more likely to develop severe pneumonia(OR:17.368,P=0.025)and be admitted to the intensive care unit(OR:27.093,P=0.048).Conclusions The increased level of BNP is associated with the undesirable condition and disease aggravation of patients with COVID-19.BNP is expected to be an independent prognostic predictor of clinical outcomes for patients with COVID-19.
