Wacker oxidation is an industry-adopted process to transform olefins into value-added epoxides and carbonyls.However,traditional Wacker oxidation involves the use of homogeneous palladium and copper catalysts for the ...Wacker oxidation is an industry-adopted process to transform olefins into value-added epoxides and carbonyls.However,traditional Wacker oxidation involves the use of homogeneous palladium and copper catalysts for the olefin addition and reductive elimination.Here,we demonstrated an ultrahigh loading Cu single atom catalyst(14%Cu,mass fraction)for the palladium-free Wacker oxidation of 4-vinylanisole into the corresponding ketone with N-methylhydroxylamine hydrochloride as an additive under mild conditions.Mechanistic studies by ^(18)O and deuterium isotope labelling revealed a hydrogen shift mechanism in this palladium-free process using N-methylhydroxylamine hydrochloride as the oxygen source.The reaction scope can be further extended to Kucherov oxidation.Our study paves the way to replace noble metal catalysts in the traditional homogeneous processes with single atom catalysts.展开更多
基金National Research Foundation,Prime Minister’s Office,Singapore(No.NRF-CRP16-2015-02).
文摘Wacker oxidation is an industry-adopted process to transform olefins into value-added epoxides and carbonyls.However,traditional Wacker oxidation involves the use of homogeneous palladium and copper catalysts for the olefin addition and reductive elimination.Here,we demonstrated an ultrahigh loading Cu single atom catalyst(14%Cu,mass fraction)for the palladium-free Wacker oxidation of 4-vinylanisole into the corresponding ketone with N-methylhydroxylamine hydrochloride as an additive under mild conditions.Mechanistic studies by ^(18)O and deuterium isotope labelling revealed a hydrogen shift mechanism in this palladium-free process using N-methylhydroxylamine hydrochloride as the oxygen source.The reaction scope can be further extended to Kucherov oxidation.Our study paves the way to replace noble metal catalysts in the traditional homogeneous processes with single atom catalysts.
