Chemical investigation of the culture extract of an endophytic Penicillium citrinum from Dendrobium officinale,afforded nine citrinin derivatives(1–9)and one peptide-polyketide hybrid GKK1032B(10).The structures of t...Chemical investigation of the culture extract of an endophytic Penicillium citrinum from Dendrobium officinale,afforded nine citrinin derivatives(1–9)and one peptide-polyketide hybrid GKK1032B(10).The structures of these compounds were determined by spectroscopic methods.The absolute configurations of 1 and 2 were determined for the first time by calculation of electronic circular dichroism(ECD)data.Among them,GKK1032B(10)showed significant cytotoxicity against human osteosarcoma cell line MG63 with an IC50 value of 3.49μmol·L–1,and a primary mechanistic study revealed that it induced the apoptosis of MG63 cells via caspase pathway activation.展开更多
The host load prediction problem in cloud computing has also been received much attention. To solve this problem, we have to use the historical load data to predict the future load level. Accurate prediction methods a...The host load prediction problem in cloud computing has also been received much attention. To solve this problem, we have to use the historical load data to predict the future load level. Accurate prediction methods are useful for host load balance and virtual machine migration. Although cloud is likely to grids at some extent, the length of tasks are much shorter and host loads change more frequently with higher noise. The above characteristics introduce challenges for host load prediction. In this paper, based on the proposed exponentially segmented pattern and the corresponding transformation, prediction problem is transformed into the traditional classification problem, This classification problem can be solved based on the traditional methods, and features are given for training the classification model. For achieving accurate prediction, a new feature periodical coefficient is introduced and some existed classification methods are implemented. Experiments on the real world dataset invalidate the efficiency of the new proposed feature, which is in the most effective combinations of features, it increases successful rate （SR） 1.33%-2.82% and decreases the mean square error （MSE） 1.37%-2.91%. And the results also show that support vector machine （SVM） method can achieve nearly the same performance as the Bayes methods and their performance is about 50% higher in successful rate and 17% better in the mean square error compared to the existed methods.展开更多
Recently, Terminal has become one of the key issues in the 3G development. In the paper, we study the mobile terminal management in 3G network. Based on the analysis of problems encountered with the terminals, the pa...Recently, Terminal has become one of the key issues in the 3G development. In the paper, we study the mobile terminal management in 3G network. Based on the analysis of problems encountered with the terminals, the paper describes the use cases of terminal management. A system architecture with its function components of mobile terminal management system is proposed. Moreover, a possible implementation solution is introduced and described. A Management Information Model （MIM） for terminal management is also proposed to support the management services.展开更多
基金the National Natural Science Foundation of China(Nos.82073728 and 31501104)the Natural Science Foundation of Shandong Province(Nos.ZR2019QH006 and JQ201721)+3 种基金the Project of Shandong Province Higher Educational Science and Technology Program(No.J17KA228)the Innovation Team Project of Jinan Science&Technology Bureau(No.2018GXRC003)the Young Taishan Scholars Program(No.tsqn20161037)Shandong Talents Team Cultivation Plan of University Preponderant Discipline(No.10027).
文摘Chemical investigation of the culture extract of an endophytic Penicillium citrinum from Dendrobium officinale,afforded nine citrinin derivatives(1–9)and one peptide-polyketide hybrid GKK1032B(10).The structures of these compounds were determined by spectroscopic methods.The absolute configurations of 1 and 2 were determined for the first time by calculation of electronic circular dichroism(ECD)data.Among them,GKK1032B(10)showed significant cytotoxicity against human osteosarcoma cell line MG63 with an IC50 value of 3.49μmol·L–1,and a primary mechanistic study revealed that it induced the apoptosis of MG63 cells via caspase pathway activation.
基金supported by the National Key project of Scientific and Technical Supporting Programs of China (2013BAH10F01, 2013BAH07F02, 2014BAH26F02)The Research Fund for the Doctoral Program of Higher Education (20110005120007)+1 种基金Beijing Higher Education Young Elite Teacher Project (YETP0445)The Co-construction Program with Beijing Municipal Commission of Education
文摘The host load prediction problem in cloud computing has also been received much attention. To solve this problem, we have to use the historical load data to predict the future load level. Accurate prediction methods are useful for host load balance and virtual machine migration. Although cloud is likely to grids at some extent, the length of tasks are much shorter and host loads change more frequently with higher noise. The above characteristics introduce challenges for host load prediction. In this paper, based on the proposed exponentially segmented pattern and the corresponding transformation, prediction problem is transformed into the traditional classification problem, This classification problem can be solved based on the traditional methods, and features are given for training the classification model. For achieving accurate prediction, a new feature periodical coefficient is introduced and some existed classification methods are implemented. Experiments on the real world dataset invalidate the efficiency of the new proposed feature, which is in the most effective combinations of features, it increases successful rate （SR） 1.33%-2.82% and decreases the mean square error （MSE） 1.37%-2.91%. And the results also show that support vector machine （SVM） method can achieve nearly the same performance as the Bayes methods and their performance is about 50% higher in successful rate and 17% better in the mean square error compared to the existed methods.
基金This workis supported by National Natural Science Foundation of China(60372098) .
文摘Recently, Terminal has become one of the key issues in the 3G development. In the paper, we study the mobile terminal management in 3G network. Based on the analysis of problems encountered with the terminals, the paper describes the use cases of terminal management. A system architecture with its function components of mobile terminal management system is proposed. Moreover, a possible implementation solution is introduced and described. A Management Information Model （MIM） for terminal management is also proposed to support the management services.
