目的分析乳腺影像报告及数据系统(breast imaging reporting and data system,BI-RADS)4类乳腺良恶性结节采用超声弹性成像(ultrasonic elastography,UE)技术诊断的价值。方法选择2023年1—11月济南市章丘区人民医院收治的102例疑似BI-R...目的分析乳腺影像报告及数据系统(breast imaging reporting and data system,BI-RADS)4类乳腺良恶性结节采用超声弹性成像(ultrasonic elastography,UE)技术诊断的价值。方法选择2023年1—11月济南市章丘区人民医院收治的102例疑似BI-RADS 4类乳腺实性结节患者为研究对象,全部患者均接受彩色多普勒超声与UE检查。以病理结果为“金标准”,针对BI-RADS 4类乳腺良恶性结节经常规超声与UE技术诊断的结果及效能,以及对UE技术诊断结果与病理结果的一致性进行评价。结果BI-RADS 4类乳腺良恶性结节经穿刺活检结果证实为恶性36例,良性66例,UE技术诊断结果与病理诊断结果具有极好的一致性(kappa=0.890)。UE技术对BI-RADS 4类乳腺良恶性结节诊断的灵敏度94.44%、特异度95.45%、准确度95.10%均高于常规超声的72.22%、81.82%、78.43%,差异有统计学意义(χ^(2)=6.400、6.092、12.337,P均<0.05)。结论UE在BI-RADS 4类乳腺良恶性结节中具有较为理想的诊断价值,进一步提高了诊断效能,为临床提供可靠的参考信息。展开更多
This study aims to explore the formation mechanism of ethyl acetate and organic acids in acid rice soup(rice-acid soup)inoculated with Kluyveromyces marxianus L1-1 through the complementary analysis of transcriptome a...This study aims to explore the formation mechanism of ethyl acetate and organic acids in acid rice soup(rice-acid soup)inoculated with Kluyveromyces marxianus L1-1 through the complementary analysis of transcriptome and proteome.The quantity of K.marxianus L1-1 varied significantly in the fermentation process of rice-acid soup and the first and third days were the two key turning points in the growth phase of K.marxianus L1-1.Importantly,the concentrations of ethyl acetate,ethanol,acetic acid,and L-lactic acid increased from day 1 to day 3.At least 4231 genes and 2937 proteins were identified and 610 differentially expressed proteins were annotated to 30 Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways based on the analysis results of transcriptome and proteome.The key genes and proteins including up-regulated alcohol dehydrogenase family,alcohol O-acetyltransferase,acetyl-CoA C-acetyltransferase,acyl-coenzyme A thioester hydrolase,and down-regulated aldehyde dehydrogenase family were involved in glycolysis/gluconeogenesis pathways,starch and sucrose metabolism pathways,amino sugar and nucleotide sugar metabolism pathways,tricarboxylic acid(TCA)cycle,and pyruvate metabolism pathways,thus promoting the formation of ethyl acetate,organic acids,alcohols,and other esters.Our results revealed the formation mechanisms of ethyl acetate and organic acids in rice-acid soup inoculated with K.marxianus L1-1.展开更多
基金financially supported by National Natural Science Foundation of China (32060530)Guizhou University, Gui Da Te Gang He Zi (2022) 39, Technology platform and talent team plan of Guizhou. China ((2018)5251)+2 种基金Graduate Research Fund Project of Guizhou (YJSCXJH(2019]028)Industry-University-Research Cooperation Project of Guizhou (701/700465172217)China Scholarship Council (201906670006)
文摘This study aims to explore the formation mechanism of ethyl acetate and organic acids in acid rice soup(rice-acid soup)inoculated with Kluyveromyces marxianus L1-1 through the complementary analysis of transcriptome and proteome.The quantity of K.marxianus L1-1 varied significantly in the fermentation process of rice-acid soup and the first and third days were the two key turning points in the growth phase of K.marxianus L1-1.Importantly,the concentrations of ethyl acetate,ethanol,acetic acid,and L-lactic acid increased from day 1 to day 3.At least 4231 genes and 2937 proteins were identified and 610 differentially expressed proteins were annotated to 30 Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways based on the analysis results of transcriptome and proteome.The key genes and proteins including up-regulated alcohol dehydrogenase family,alcohol O-acetyltransferase,acetyl-CoA C-acetyltransferase,acyl-coenzyme A thioester hydrolase,and down-regulated aldehyde dehydrogenase family were involved in glycolysis/gluconeogenesis pathways,starch and sucrose metabolism pathways,amino sugar and nucleotide sugar metabolism pathways,tricarboxylic acid(TCA)cycle,and pyruvate metabolism pathways,thus promoting the formation of ethyl acetate,organic acids,alcohols,and other esters.Our results revealed the formation mechanisms of ethyl acetate and organic acids in rice-acid soup inoculated with K.marxianus L1-1.
基金Project(52275350)supported by the National Natural Science Foundation of ChinaProject(0301006)supported by International Cooperative Scientific Research Platform of SUES,China。