Objective:To investigate the association between the development of diabetic retinopathy and OCTA blood flow density.Methods:A total of 63 patients(100 eyes)diagnosed with type 2 diabetes in Eye Hospital of China Acad...Objective:To investigate the association between the development of diabetic retinopathy and OCTA blood flow density.Methods:A total of 63 patients(100 eyes)diagnosed with type 2 diabetes in Eye Hospital of China Academy of Chinese Medical Sciences from September 2020 to July 2021 were selected,including 44 patients(72 eyes)with diabetic retinopathy and 19 patients(28 eyes)with type 2 diabetes without retinopathy(NDR).All patients underwent OCTA examination,and FAZ,PERIM,AI,FD,SVD,DVD and other indicators were counted.Results:(1)SVD,parafoveal SVD,DVD and parafoveal DVD gradually decreased with the progression of DR(P=0.000).There was no significant difference in SVD and DVD fovea(P>0.05).(2)The correlation coefficients between SVD,SVD,DVD,DVD and DR process were-0.525,-0.586,-0.323,-0.424,respectively(P<0.05),and all showed moderate negative correlation.(3)AI and FD gradually decreased with the progression of DR,and the differences were statistically significant(P=0.011,P=0.000),while FAZ and PERIM showed no significant difference with the progression of DR(P>0.05).(4)The correlation coefficients of FAZ,PERIM and DR progression were:-0.031,0.084(P>0.05),no correlation,AI,FD and DR process correlation coefficient were 0.307,-0.459(P<0.05),respectively,were moderately positive and negative correlation;(5)The correlation coefficients of FAZ,PERIM,AI,FD and age were-0.124,-0.052,0.113,-0.170(P>0.05),respectively.Conclusion:There is a moderate correlation between the progression of DR and the superficial and deep blood flow density of OCTA.It was moderately correlated with AI and FD.OCTA can assist in the assessment of DR disease progression.展开更多
Objective:To systematically evaluate the association between MCP-1 gene-2518 A/G polymorphism and diabetic retinopathy(DR).Methods:CNKI,WanFang Data,and PubMed databases were searched.Studies on the correlation betwee...Objective:To systematically evaluate the association between MCP-1 gene-2518 A/G polymorphism and diabetic retinopathy(DR).Methods:CNKI,WanFang Data,and PubMed databases were searched.Studies on the correlation between MCP-1 gene-2518A/G polymorphism and DR were searched from self-built databases until March 2022.Meta-analysis was performed using Revman5.3 software.Results:Seven studies were included.Meta-analysis showed that MCP-1 gene 2518A/G was not associated with the risk of DR in allelic and homozygous genetic models[G vs.A:OR=1.09,95%CI(0.77,1.54),P=0.62;GG vs.AA:OR=1.64,95%CI(0.93,2.88),P=0.09],and it was correlated with the risk of DR in heterozygous,dominant and recessive genetic models[GG vs.AG:OR=1.13,95%CI(1.01,1.26),P=0.03;AA+AG vs.GG:OR=0.85,95%CI(0.77,0.94),P=0.002;AA vs.GG+AG:[OR=0.78,95%CI(0.67,0.90),P=0.0008];According to the severity of DR,further meta-analysis of proliferative diabetic retinopathy(PDR)and nonproliferative diabetic retinopathy(NPDR)patients showed that there was no correlation between MCP-1 gene-2518A/G polymorphism and the risk of PDR in five genetic models[G vs.A:OR=1.06,95%CI(0.80,1.41),P=0.68;GG vs.AA:OR=1.12,95%CI(0.77,1.61),P=0.56;GG vs.AG:OR=0.88,95%CI(0.69,1.12),P=0.31;AA+AG vs.GG:OR=1.08,95%CI(0.86,1.36),P=0.50;AA vs.GG+AG:[OR=0.73,95%CI(0.49,1.08),P=0.12].Conclusion:MCP-1 gene 2518A/G polymorphism may be associated with the pathogenesis of DR,but it may not be involved in the progression of DR patients from NPDR to PDR.展开更多
基金National Natural Science Foundation of China,No.81874494Natural Science Foundation of Beijing(7182187)+1 种基金Capital Health Development Research Project(2020-2-4182,2020-3-4184)Science and TechnologyInnovation Project of China Academy of Chinese Medical Sciences(CI2021A02604)。
文摘Objective:To investigate the association between the development of diabetic retinopathy and OCTA blood flow density.Methods:A total of 63 patients(100 eyes)diagnosed with type 2 diabetes in Eye Hospital of China Academy of Chinese Medical Sciences from September 2020 to July 2021 were selected,including 44 patients(72 eyes)with diabetic retinopathy and 19 patients(28 eyes)with type 2 diabetes without retinopathy(NDR).All patients underwent OCTA examination,and FAZ,PERIM,AI,FD,SVD,DVD and other indicators were counted.Results:(1)SVD,parafoveal SVD,DVD and parafoveal DVD gradually decreased with the progression of DR(P=0.000).There was no significant difference in SVD and DVD fovea(P>0.05).(2)The correlation coefficients between SVD,SVD,DVD,DVD and DR process were-0.525,-0.586,-0.323,-0.424,respectively(P<0.05),and all showed moderate negative correlation.(3)AI and FD gradually decreased with the progression of DR,and the differences were statistically significant(P=0.011,P=0.000),while FAZ and PERIM showed no significant difference with the progression of DR(P>0.05).(4)The correlation coefficients of FAZ,PERIM and DR progression were:-0.031,0.084(P>0.05),no correlation,AI,FD and DR process correlation coefficient were 0.307,-0.459(P<0.05),respectively,were moderately positive and negative correlation;(5)The correlation coefficients of FAZ,PERIM,AI,FD and age were-0.124,-0.052,0.113,-0.170(P>0.05),respectively.Conclusion:There is a moderate correlation between the progression of DR and the superficial and deep blood flow density of OCTA.It was moderately correlated with AI and FD.OCTA can assist in the assessment of DR disease progression.
基金National Natural Science Foundation of China(No.81874494)Capital Health Development Project(No.2020-2-4182,2020-3-4184)Science and Technology Innovation Project of China Academy of Chinese Medical Sciences(No.CI2021A02604)。
文摘Objective:To systematically evaluate the association between MCP-1 gene-2518 A/G polymorphism and diabetic retinopathy(DR).Methods:CNKI,WanFang Data,and PubMed databases were searched.Studies on the correlation between MCP-1 gene-2518A/G polymorphism and DR were searched from self-built databases until March 2022.Meta-analysis was performed using Revman5.3 software.Results:Seven studies were included.Meta-analysis showed that MCP-1 gene 2518A/G was not associated with the risk of DR in allelic and homozygous genetic models[G vs.A:OR=1.09,95%CI(0.77,1.54),P=0.62;GG vs.AA:OR=1.64,95%CI(0.93,2.88),P=0.09],and it was correlated with the risk of DR in heterozygous,dominant and recessive genetic models[GG vs.AG:OR=1.13,95%CI(1.01,1.26),P=0.03;AA+AG vs.GG:OR=0.85,95%CI(0.77,0.94),P=0.002;AA vs.GG+AG:[OR=0.78,95%CI(0.67,0.90),P=0.0008];According to the severity of DR,further meta-analysis of proliferative diabetic retinopathy(PDR)and nonproliferative diabetic retinopathy(NPDR)patients showed that there was no correlation between MCP-1 gene-2518A/G polymorphism and the risk of PDR in five genetic models[G vs.A:OR=1.06,95%CI(0.80,1.41),P=0.68;GG vs.AA:OR=1.12,95%CI(0.77,1.61),P=0.56;GG vs.AG:OR=0.88,95%CI(0.69,1.12),P=0.31;AA+AG vs.GG:OR=1.08,95%CI(0.86,1.36),P=0.50;AA vs.GG+AG:[OR=0.73,95%CI(0.49,1.08),P=0.12].Conclusion:MCP-1 gene 2518A/G polymorphism may be associated with the pathogenesis of DR,but it may not be involved in the progression of DR patients from NPDR to PDR.
