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齐拉西酮治疗奥氮平致体重增加精神分裂症患者的效果和安全性 被引量:10
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作者 宋新虹 贺守彬 《中国当代医药》 2019年第1期91-93,97,共4页
目的探讨齐拉西酮治疗奥氮平致体重增加精神分裂症患者的效果和安全性。方法选取2016年1月~2018年1月我院收治的84例精神分裂症患者作为研究对象,采用随机数字表法将其分为试验组和参照组,每组各42例。参照组患者采用奥氮平治疗,试验... 目的探讨齐拉西酮治疗奥氮平致体重增加精神分裂症患者的效果和安全性。方法选取2016年1月~2018年1月我院收治的84例精神分裂症患者作为研究对象,采用随机数字表法将其分为试验组和参照组,每组各42例。参照组患者采用奥氮平治疗,试验组患者给予齐拉西酮联合奥氮平治疗。治疗8周后,采用阳性和阴性症状量表(PANSS)和精神科不良反应量表(UKU)评估两组患者的治疗效果和不良反应,并观察两组患者治疗前后的体重、体重指数(BMI)、空腹血糖(GLU)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)。结果两组患者治疗前的PANSS评分比较,差异无统计学意义(P>0.05);两组患者治疗后的PANSS评分均明显低于治疗前,差异有统计学意义(P<0.05);两组患者治疗后的PANSS评分比较,差异无统计学意义(P>0.05)。两组患者治疗前的体重、BMI、GLU、TG、TC、HDL、LDL比较,差异无统计学意义(P>0.05);参照组患者治疗后的体重、BMI、GLU、TG、TC、HDL、LDL均高于治疗前,差异有统计学意义(P<0.05);试验组患者治疗前后的体重、BMI、GLU、TG、TC、HDL、LDL比较,差异无统计学意义(P>0.05);试验组患者治疗后的体重、BMI、GLU、TG、TC、LDL均低于参照组,差异有统计学意义(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论齐拉西酮能改善奥氮平治疗精神分裂症引起的糖脂代谢紊乱状态,从而有效防止体重增加,且安全性较高,值得临床推广和应用。 展开更多
关键词 精神分裂症 奥氮平 体重增加 代谢障碍 齐拉西酮
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MRI新技术在直肠癌临床应用研究进展 被引量:6
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作者 宋新红 王培源 《磁共振成像》 CAS CSCD 2018年第7期550-555,共6页
直肠癌是最常见的胃肠道肿瘤。准确的TN分期不仅可以指导治疗方案的制订,还可以预测术后复发及评估预后。MRI是目前直肠癌最准确的术前分期影像检查手段。应用于胃肠道的MRI新扫描技术,如高分辨率MRI、体素内不相干运动扩散加权成像、... 直肠癌是最常见的胃肠道肿瘤。准确的TN分期不仅可以指导治疗方案的制订,还可以预测术后复发及评估预后。MRI是目前直肠癌最准确的术前分期影像检查手段。应用于胃肠道的MRI新扫描技术,如高分辨率MRI、体素内不相干运动扩散加权成像、动态增强磁共振成像等,可以提高直肠癌术前TN分期的准确性,降低术后复发率,改善患者预后。作者对这些新技术在直肠癌临床诊疗、疗效评价及预后评估方面的应用研究进行综述。 展开更多
关键词 直肠肿瘤 磁共振成像
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Distribution of serum prostate-specific antigen in Chinese healthy men: a population-based study 被引量:12
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作者 YUAN Xiao-dong DONG Zhi-gang +7 位作者 ZHANG Hui LIN Hai-yan song xin-hong NIU Zhi-hong FU Qiang LIU Shuai SUN Zhi-jian LU Jia-ju 《Chinese Medical Journal》 SCIE CAS CSCD 2011年第8期1189-1192,共4页
Background The morbidity and mortality of prostate cancer have been increasing rapidly in recent China. There were few studies investigating prostate-specific antigen (PSA) values ranges in the healthy Chinese popul... Background The morbidity and mortality of prostate cancer have been increasing rapidly in recent China. There were few studies investigating prostate-specific antigen (PSA) values ranges in the healthy Chinese population. We performed this study to determine the distribution of serum PSA in a large healthy Chinese population.Methods From January 2001 to May 2008, 11 150 healthy Chinese men aged 30-79 years came to our hospital for routine health check-up. All subjects without a previous diagnosis of prostate cancer, a history of prostate surgery, or urogenital tract infection were proposed to undergo systematic serum PSA measurement and digital rectal examination (DRE). Men with normal DRE and PSA ≤4.0 ng/ml and those PSA >4.0 ng/ml or abnormal DRE but without adverse findings on prostate biopsy were included (n=9358). Age and serum PSA concentration were recorded and correlated through Logistic regression analysis.Results The 95th percentile serum PSA concentration was 1.89 ng/ml for men aged 30 to 39 years, 2.19 ng/ml for men aged 40 to 49 years, 2.88 ng/ml for men aged 50 to 59 years, 4.42 rng/ml for men aged 60 to 69 years, and 6.52 ng/ml for men aged 70 to 79 years. The serum PSA concentration correlated with age (P <0.0001) with an annual increase of 0.97% for men in 40 years, 1.58% for men in 50 years, 3.04% for men in 60 years, and 3.99% for men in 70 years.Conclusions The serum PSA level correlates directly with age in Chinese men older than 40 years, not in Chinese men younger than 40 years old. Chinese men have lower PSA level compared with white men above 60 years of age, not in those under 60 years of age. 展开更多
关键词 ASIAN CAUCASIAN CHINESE prostate-specific antigen reference ranges
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