HIV-1 Nef protein plays an important role in HIV-1 pathogenesis, including downregulation of the cell surface CD4 and class I major histocompatibility complex （MHC）, enhancement of virion infectivity and alteration ...HIV-1 Nef protein plays an important role in HIV-1 pathogenesis, including downregulation of the cell surface CD4 and class I major histocompatibility complex （MHC）, enhancement of virion infectivity and alteration of a variety of cellular signal transduction pathways.1.2 A recent report demonstrated that Nef down-regulates dendritic cell surface expression of MHC class I and up-regulates molecules known to be critical for apoptosis induction, such as TNF-α and FasL^3 It is also very interesting that Nef expression alone may be sufficient to cause an AIDS-like disease in transgenic mice.2 In many human cohort studies it has been reported that long-term nonprogressors （LTNPs）, who remain asymptomatic for more than one decade without antiretroviral therapy, harbored nef-deleted viruses.4-7 Intense studies on nef genes from LTNPs have been done in Europe and United States but none of such studies have been done in China.展开更多
基金the NIH CIPRA(No.1U19 A151915-03)the "973" National Key Project (No.G1999054107)the National Outstanding Youth Grant(No.39925030).
文摘HIV-1 Nef protein plays an important role in HIV-1 pathogenesis, including downregulation of the cell surface CD4 and class I major histocompatibility complex （MHC）, enhancement of virion infectivity and alteration of a variety of cellular signal transduction pathways.1.2 A recent report demonstrated that Nef down-regulates dendritic cell surface expression of MHC class I and up-regulates molecules known to be critical for apoptosis induction, such as TNF-α and FasL^3 It is also very interesting that Nef expression alone may be sufficient to cause an AIDS-like disease in transgenic mice.2 In many human cohort studies it has been reported that long-term nonprogressors （LTNPs）, who remain asymptomatic for more than one decade without antiretroviral therapy, harbored nef-deleted viruses.4-7 Intense studies on nef genes from LTNPs have been done in Europe and United States but none of such studies have been done in China.
