Resista nee to anticancer drugs is a major problem in on cology,which causes the failure of an titumor treatme nt.A variety of factors con tribute to drug resistance,in eluding drug efflux and metabolism,tumor cell he...Resista nee to anticancer drugs is a major problem in on cology,which causes the failure of an titumor treatme nt.A variety of factors con tribute to drug resistance,in eluding drug efflux and metabolism,tumor cell heteroge neity,tumor microenvironment stress-induced genetic or epigenetic alterations in the cancer cells and so on.However,how to circumvent this resista nee to improve antican cer efficacy remains to be determined.To circumvent chemotherapeutic resista nee,many reversal agents have been developed,but most of them fail in clinical trials due to severe adverse effects.Recently,several natural products have been reported to augme nt sen sitivity or overcome resista nee of an ticancer chemotherapeutic drugs,including elemene,curcumin,Shenqi Fuzheng Injection(参芪扶正注射液),PHY906,etc.Thus,understand!ng the novel function of Chinese medicine may allow us to develop a promising therapeutic approach to enhance the effects of anticancer strategies and preve nt or overcome their resista nee in the treatment of can cer patie nts.展开更多
Applying Chinese medicine(CM) is an important strategy for malignant tumor treatment in China. One of the significant characteristics of CM is to treat diseases based on syndrome differentiation. For Western medicine,...Applying Chinese medicine(CM) is an important strategy for malignant tumor treatment in China. One of the significant characteristics of CM is to treat diseases based on syndrome differentiation. For Western medicine, it is of important clinical significance to formulate guidelines for the diagnosis and treatment of cancer patients based on the characteristics of disease differentiation. In Chinese clinical practice, the combination of disease differentiation and syndrome differentiation is an important feature for cancer treatment in the past. Currently, molecular profiling and genomic analysis-based precision medicine optimizes the anticancer drug design and holds the greatest success in treating cancer patients. Therefore, we want to know which populations of cancer patients can benefit more from CM treatment if the theory of precision medicine is applied to CM clinical practice. So, we developed a novel diagnostic and therapeutic strategy "disease-syndrome differentiation-genomic profilingprescriptions" for cancer patients by CM syndrome differentiation and precision medicine. As a result, this strategy has greatly enhanced the anti-tumor efficacy of CM and improved clinical outcomes for cancer patients with some gene mutations. Our idea will hopefully establish a novel approach for the inheritance and innovation of CM.展开更多
基金Supported by the National Natural Science Foundation of China(No.81672932,81730108,81874380 and 81973635)Zhejiang Provincial Natural Scienee Foundation of China for Distinguished Young Scholars(No.LR18H160001)+3 种基金Zhejia ng Provi nee Scie nee and Tech no logy Project of TCM(No.2019ZZ016)Zhejiang Provinee Medical Science and Tech no logy Project(No.2017RC007)Tale nt Project of Zhejia ng Associati on for Scie nee and Tech no logy(No.2017YCGC002)Key Project of Hangzhou Ministry of Science and Technology(No.20162013A07)。
文摘Resista nee to anticancer drugs is a major problem in on cology,which causes the failure of an titumor treatme nt.A variety of factors con tribute to drug resistance,in eluding drug efflux and metabolism,tumor cell heteroge neity,tumor microenvironment stress-induced genetic or epigenetic alterations in the cancer cells and so on.However,how to circumvent this resista nee to improve antican cer efficacy remains to be determined.To circumvent chemotherapeutic resista nee,many reversal agents have been developed,but most of them fail in clinical trials due to severe adverse effects.Recently,several natural products have been reported to augme nt sen sitivity or overcome resista nee of an ticancer chemotherapeutic drugs,including elemene,curcumin,Shenqi Fuzheng Injection(参芪扶正注射液),PHY906,etc.Thus,understand!ng the novel function of Chinese medicine may allow us to develop a promising therapeutic approach to enhance the effects of anticancer strategies and preve nt or overcome their resista nee in the treatment of can cer patie nts.
基金Supported by the National Natural Science Foundation of China (Nos.81874380 and 82022075, 81730108 and 81973635)Zhejiang Province Science and Technology Project of TCM (No.2021ZQ058)。
文摘Applying Chinese medicine(CM) is an important strategy for malignant tumor treatment in China. One of the significant characteristics of CM is to treat diseases based on syndrome differentiation. For Western medicine, it is of important clinical significance to formulate guidelines for the diagnosis and treatment of cancer patients based on the characteristics of disease differentiation. In Chinese clinical practice, the combination of disease differentiation and syndrome differentiation is an important feature for cancer treatment in the past. Currently, molecular profiling and genomic analysis-based precision medicine optimizes the anticancer drug design and holds the greatest success in treating cancer patients. Therefore, we want to know which populations of cancer patients can benefit more from CM treatment if the theory of precision medicine is applied to CM clinical practice. So, we developed a novel diagnostic and therapeutic strategy "disease-syndrome differentiation-genomic profilingprescriptions" for cancer patients by CM syndrome differentiation and precision medicine. As a result, this strategy has greatly enhanced the anti-tumor efficacy of CM and improved clinical outcomes for cancer patients with some gene mutations. Our idea will hopefully establish a novel approach for the inheritance and innovation of CM.
