The coupled ice- ocean model for the Bohai Sea is used for simulating the freezing, melting, and variation of ice cover and the heat bal- ance at the sea- ice, air- ice, and air- sea interfaces of the Bohai Sea during...The coupled ice- ocean model for the Bohai Sea is used for simulating the freezing, melting, and variation of ice cover and the heat bal- ance at the sea- ice, air- ice, and air- sea interfaces of the Bohai Sea during the entire winter in 1998￣1999 and 2000￣2001. The cou- pled model is forced by real time numerical weather prediction fields. The results show that the thermodynamic effects of atmosphere and ocean are very important for the evolvement of ice in the Bohai Sea, especially in the period of ice freezing and melting. Ocean heat flux plays a key role in the thermodynamic coupling. The simulation also presents the different thermodynamic features in the ice covered region and the marginal ice zone. Ice thickness, heat budget at the interface, and surface sea temperature, etc. between the two representative points are discussed.展开更多
According to the earlier international studies on the coupled iceocean model and the hydrology, meteorology, and icefeatures in the Bohai Sea, a coupled iceocean model is developed based on the National Marine Environ...According to the earlier international studies on the coupled iceocean model and the hydrology, meteorology, and icefeatures in the Bohai Sea, a coupled iceocean model is developed based on the National Marine EnvironmentForecast Centers (NMEFC) numerical forecasting ice model of the Bohai Sea and the Princeton ocean model (POM).In the coupled model, the transfer of momentum and heat between ocean and ice is two-way, and the change of icethickness and concentration depends on heat budget not only at the surface and bottom of ice, but also at the surfaceof open water between ices. The dynamic and thermodynamic coupling process is expatiated emphatically. Somethermodynamic parameters are discussed as well.展开更多
OBJECTIVE Nowadays,with the living habits and diet structure changes,the morbidity and mortality of hypertension has been rising yearly,which induced by adverse lifestyles,excessive alcohol and poor diet.However,the a...OBJECTIVE Nowadays,with the living habits and diet structure changes,the morbidity and mortality of hypertension has been rising yearly,which induced by adverse lifestyles,excessive alcohol and poor diet.However,the animal models of hypertension resulted from adverse lifestyles have rarely been reported.It is essential to set up some more systematic models to study the characters of hypertension and evaluate the efficacy of traditional Chinese medicine(TCM).METHODS To build the rat model of human lifehabitual hypertension,SD rats had free access to alcohol with high-sucrose-fat diet(AHSFD),alcohol with high-fat diet(AHFD),high-sucrose-fat diet(HSFD),high-fat diet(HFD)and alcohol etc.Various of indicators were detected systematically to explore the features of hypertension models which included blood pressure(BP),liver and kidney functions,the lipid profiles and indexes quantifying TCM symptoms.Then we choose one of the stable and sustained animal models,studying the effects of RPA.E(which extracted from a TCM)on modulating the level of hypertension and the preliminary mechanism in this abstract.RESULTS ①The BP level,serum TC,TG,LDL-C of AHSFD-induced and AHFD-induced rats increased significantly,while the HDL-C reduced in the 4th week.② The BP level HSFD-induced rats increased significantly in the 6th week,serum TC,TG increased in 10 th week.③ The BP level of alcohol-induced rats increased significantly in the 9th week,serum TC,TG increased in 24 th week.④ The level of serum ALT,AST,UA and Cr of all model rats increased significantly after 12 weeks.Meanwhile the microcirculation increased significantly after8 weeks.⑤ After 4-week administration,RPA.E could significantly reduce BP of AHFD-induced hypertensive rats,and could reduce the serum TC,LDL-C,HDL-C,ALT,AST level after 8-week.CONCLUSION The rats induced by AHSFD,AHFD,HSFD and alcohol can raise BP obviously with underlying hepatic and kidney damage,the lipid profiles disorder and TCM symptoms change,while the AH(S)FD-induced hypertension models are earlier and more stable.RPA.E could mildly reduce BP level,and improve the lipid profiles disorders,hepatic damage,which reflects the characteristics of TCM on antihypertensive effects.The above models have their own characteristics,can be used to study the causes and pathogenesis of hypertension complicating metabolic disorder and the related treatment drug screening.展开更多
基金supported by the National Natural Science Foundation of China under contract Nos 40233032 and 40376006the National High Technolo-gy Research and Development Program of China(“863")under contract Nos 2002AA639340 and 2001 AA631070the Principal Project under contract Nos 2001DIA50040 and 2001CB7l1006.
文摘The coupled ice- ocean model for the Bohai Sea is used for simulating the freezing, melting, and variation of ice cover and the heat bal- ance at the sea- ice, air- ice, and air- sea interfaces of the Bohai Sea during the entire winter in 1998￣1999 and 2000￣2001. The cou- pled model is forced by real time numerical weather prediction fields. The results show that the thermodynamic effects of atmosphere and ocean are very important for the evolvement of ice in the Bohai Sea, especially in the period of ice freezing and melting. Ocean heat flux plays a key role in the thermodynamic coupling. The simulation also presents the different thermodynamic features in the ice covered region and the marginal ice zone. Ice thickness, heat budget at the interface, and surface sea temperature, etc. between the two representative points are discussed.
基金the National Natural Science Foundation of China under contract Nos40233032 , 40376006the National High Technology Research and Development Program(863) of China under contract Nos 2002AA639340 , 2001AA631070 the Principal Project under contract Nos2001DIA50040 , 2001CB711006.
文摘According to the earlier international studies on the coupled iceocean model and the hydrology, meteorology, and icefeatures in the Bohai Sea, a coupled iceocean model is developed based on the National Marine EnvironmentForecast Centers (NMEFC) numerical forecasting ice model of the Bohai Sea and the Princeton ocean model (POM).In the coupled model, the transfer of momentum and heat between ocean and ice is two-way, and the change of icethickness and concentration depends on heat budget not only at the surface and bottom of ice, but also at the surfaceof open water between ices. The dynamic and thermodynamic coupling process is expatiated emphatically. Somethermodynamic parameters are discussed as well.
基金The project supported by National Natural Science Foundation of China(81274123,81374003)National Major Scientific and Technological Specialized Project for the Significant Formulation of New Drugs,China(2011ZX09101-002-07,2009ZX09502-016)
文摘OBJECTIVE Nowadays,with the living habits and diet structure changes,the morbidity and mortality of hypertension has been rising yearly,which induced by adverse lifestyles,excessive alcohol and poor diet.However,the animal models of hypertension resulted from adverse lifestyles have rarely been reported.It is essential to set up some more systematic models to study the characters of hypertension and evaluate the efficacy of traditional Chinese medicine(TCM).METHODS To build the rat model of human lifehabitual hypertension,SD rats had free access to alcohol with high-sucrose-fat diet(AHSFD),alcohol with high-fat diet(AHFD),high-sucrose-fat diet(HSFD),high-fat diet(HFD)and alcohol etc.Various of indicators were detected systematically to explore the features of hypertension models which included blood pressure(BP),liver and kidney functions,the lipid profiles and indexes quantifying TCM symptoms.Then we choose one of the stable and sustained animal models,studying the effects of RPA.E(which extracted from a TCM)on modulating the level of hypertension and the preliminary mechanism in this abstract.RESULTS ①The BP level,serum TC,TG,LDL-C of AHSFD-induced and AHFD-induced rats increased significantly,while the HDL-C reduced in the 4th week.② The BP level HSFD-induced rats increased significantly in the 6th week,serum TC,TG increased in 10 th week.③ The BP level of alcohol-induced rats increased significantly in the 9th week,serum TC,TG increased in 24 th week.④ The level of serum ALT,AST,UA and Cr of all model rats increased significantly after 12 weeks.Meanwhile the microcirculation increased significantly after8 weeks.⑤ After 4-week administration,RPA.E could significantly reduce BP of AHFD-induced hypertensive rats,and could reduce the serum TC,LDL-C,HDL-C,ALT,AST level after 8-week.CONCLUSION The rats induced by AHSFD,AHFD,HSFD and alcohol can raise BP obviously with underlying hepatic and kidney damage,the lipid profiles disorder and TCM symptoms change,while the AH(S)FD-induced hypertension models are earlier and more stable.RPA.E could mildly reduce BP level,and improve the lipid profiles disorders,hepatic damage,which reflects the characteristics of TCM on antihypertensive effects.The above models have their own characteristics,can be used to study the causes and pathogenesis of hypertension complicating metabolic disorder and the related treatment drug screening.
