Objective:To investigate the therapeutic efficacy and underlying mechanisms of LiZhong Tang in the context of non-alcoholic fatty liver disease(NAFLD).Methods:High-fat feed was used to induce NAFLD in rats,Blood and l...Objective:To investigate the therapeutic efficacy and underlying mechanisms of LiZhong Tang in the context of non-alcoholic fatty liver disease(NAFLD).Methods:High-fat feed was used to induce NAFLD in rats,Blood and liver samples were collected to facilitate a comparative analysis of rat body mass and liver wet weight and calculate the liver index.Liver pathology was observed,while serum transaminase and blood lipid levels were measured.The protein expression levels of PINK1,Parkin,and LC-3II in rat liver were detected using Western Blot analysis.Results:Compared with the control group,the NAFLD rats exhibited a significant increase in body weight,liver wet weight,liver index,transaminase levels,and blood lipid levels.The expression levels of PINK1,Parkin,and LC3-II protein were significantly decreased(P<0.01).Following intervention with Lizhong Tang,rats in each herbal treatment group displayed a decrease in body weight,liver wet weight,liver index,se-rum transaminase,and blood lipid levels.The expression levels of PINK1,Parkin,and LC-3II rebounded(P<0.05),with the high-dose group demonstrating the most pronounced effects(P<0.01).Histopathological examination of liver tissue revealed that rats in the model group displayed disrupted hepatic lobule structure,swollen hepatocytes,disordered arrangement,and a multi-tude of varying-sized lipid vacuoles within the cytoplasm.Conversely,rats treated with different doses of the herbal remedy exhibited improvements in liver tissue pathology,with the high-dose group showing the most notable enhancement.Conclusion:Lizhong Tang can improve NAFLD disease by regulating mitochondrial autophagy.展开更多
For a handlebody H w ith dH = 5, let F belong S be an essential connected subsurface of S. Let C(S) be the curve complex of S, AC(F) be the arc and curve complex of F , D(H) belong C(S) be ...For a handlebody H w ith dH = 5, let F belong S be an essential connected subsurface of S. Let C(S) be the curve complex of S, AC(F) be the arc and curve complex of F , D(H) belong C(S) be the disk complex of H and πf(D (H ) ) belong AC(F) be the image of D (H) in AC (F). We introduce the definition of subsurface 1-distance between the 1-simplices of AC(F) and show that under some hypothesis, πF(D(H) ) comes within subsurface 1-distance at most 4 of every 1-simplex of AC (F).展开更多
Let Hn be an orientable handlebody of genus n. It has been proved that for n not less than 2, there exists an annulus-busting curve in δHm. In the present paper, we prove that for n not less than 2, there exists an e...Let Hn be an orientable handlebody of genus n. It has been proved that for n not less than 2, there exists an annulus-busting curve in δHm. In the present paper, we prove that for n not less than 2, there exists an essential simple closed curve C in OHm which intersects each essential planar surface in Hn non-emptily. Furthermore, we show that for n not less than 3, a pants-busting curve must also be an annulus-busting curve.展开更多
基金Youth Fund of Guangxi Natural Science Foundat ion (No.2020GXNSFBA297133)Guangxi Traditional Chinese Medicine Administration Science and Technology Project (No.GZSY20-60)+1 种基金Natural Science Youth Fund of Guangxi University of Traditional Chinese Medicine (No.2020QN020)Guangxi Qihuang Scholar Training Project.
文摘Objective:To investigate the therapeutic efficacy and underlying mechanisms of LiZhong Tang in the context of non-alcoholic fatty liver disease(NAFLD).Methods:High-fat feed was used to induce NAFLD in rats,Blood and liver samples were collected to facilitate a comparative analysis of rat body mass and liver wet weight and calculate the liver index.Liver pathology was observed,while serum transaminase and blood lipid levels were measured.The protein expression levels of PINK1,Parkin,and LC-3II in rat liver were detected using Western Blot analysis.Results:Compared with the control group,the NAFLD rats exhibited a significant increase in body weight,liver wet weight,liver index,transaminase levels,and blood lipid levels.The expression levels of PINK1,Parkin,and LC3-II protein were significantly decreased(P<0.01).Following intervention with Lizhong Tang,rats in each herbal treatment group displayed a decrease in body weight,liver wet weight,liver index,se-rum transaminase,and blood lipid levels.The expression levels of PINK1,Parkin,and LC-3II rebounded(P<0.05),with the high-dose group demonstrating the most pronounced effects(P<0.01).Histopathological examination of liver tissue revealed that rats in the model group displayed disrupted hepatic lobule structure,swollen hepatocytes,disordered arrangement,and a multi-tude of varying-sized lipid vacuoles within the cytoplasm.Conversely,rats treated with different doses of the herbal remedy exhibited improvements in liver tissue pathology,with the high-dose group showing the most notable enhancement.Conclusion:Lizhong Tang can improve NAFLD disease by regulating mitochondrial autophagy.
文摘For a handlebody H w ith dH = 5, let F belong S be an essential connected subsurface of S. Let C(S) be the curve complex of S, AC(F) be the arc and curve complex of F , D(H) belong C(S) be the disk complex of H and πf(D (H ) ) belong AC(F) be the image of D (H) in AC (F). We introduce the definition of subsurface 1-distance between the 1-simplices of AC(F) and show that under some hypothesis, πF(D(H) ) comes within subsurface 1-distance at most 4 of every 1-simplex of AC (F).
基金The grant (09XBKQ09) of Harbin Normal Universitythe NSF (11101058) of ChinaChina Postdoctoral Science Foundation (2011M500049)
文摘Let Hn be an orientable handlebody of genus n. It has been proved that for n not less than 2, there exists an annulus-busting curve in δHm. In the present paper, we prove that for n not less than 2, there exists an essential simple closed curve C in OHm which intersects each essential planar surface in Hn non-emptily. Furthermore, we show that for n not less than 3, a pants-busting curve must also be an annulus-busting curve.