Objective:Xenon is an inhalation anesthetic with a favorable safety profile,and previous studies have demonstrated the neuroprotective efficacy of xenon in Alzheimer’s disease,spinal cord ischemia/reperfusion injury,...Objective:Xenon is an inhalation anesthetic with a favorable safety profile,and previous studies have demonstrated the neuroprotective efficacy of xenon in Alzheimer’s disease,spinal cord ischemia/reperfusion injury,intrauterine asphyxia and neonatal asphyxia.Further studies confirmed the inhibition of uptake and efflux of glutamate and mediating the neuroprotective effect through the inhibition of excessive excitation and anti-apoptosis.However,whether xenon plays a role in epilepsy remains unclear.This study aimed to investigate the role of xenon treatment in kainic acid(KA)-induced acute generalized epileptic seizures in male Sprague-Dawley rats.Methods:All rats were treated with KA(1 mg/0.8 ml,0.65μl/rat),which was injected into the lateral ventricle through the cannula.Seizure severity was staged as 1~5 based on Racine’s criteria.Rats in the xenon group were treated with xenon mixture(70%xenon/30%oxygen)for 1 h immediately after KA injection,while rats in the control group were treated with 70%nitrogen/30%oxygen.In order to assess the role of autophagy in the antiepileptic effects induced by xenon,the inhibitors of autophagy(3-methyladenine,3-MA or bafilomycin A1,BafA1)and the inducer of autophagy(rapamycin)were administered before xenon展开更多
文摘Objective:Xenon is an inhalation anesthetic with a favorable safety profile,and previous studies have demonstrated the neuroprotective efficacy of xenon in Alzheimer’s disease,spinal cord ischemia/reperfusion injury,intrauterine asphyxia and neonatal asphyxia.Further studies confirmed the inhibition of uptake and efflux of glutamate and mediating the neuroprotective effect through the inhibition of excessive excitation and anti-apoptosis.However,whether xenon plays a role in epilepsy remains unclear.This study aimed to investigate the role of xenon treatment in kainic acid(KA)-induced acute generalized epileptic seizures in male Sprague-Dawley rats.Methods:All rats were treated with KA(1 mg/0.8 ml,0.65μl/rat),which was injected into the lateral ventricle through the cannula.Seizure severity was staged as 1~5 based on Racine’s criteria.Rats in the xenon group were treated with xenon mixture(70%xenon/30%oxygen)for 1 h immediately after KA injection,while rats in the control group were treated with 70%nitrogen/30%oxygen.In order to assess the role of autophagy in the antiepileptic effects induced by xenon,the inhibitors of autophagy(3-methyladenine,3-MA or bafilomycin A1,BafA1)and the inducer of autophagy(rapamycin)were administered before xenon
