To improve the global convergence speed of social cognitive optimization （SCO） algorithm, a hybrid social cognitive optimization （HSCO） algorithm based on elitist strategy and chaotic optimization is proposed to s...To improve the global convergence speed of social cognitive optimization （SCO） algorithm, a hybrid social cognitive optimization （HSCO） algorithm based on elitist strategy and chaotic optimization is proposed to solve constrained nonlinear programming problems （NLPs）. The proposed algorithm partitions learning agents into three groups in proportion： elite learning agents, chaotic learning agents and common learning agents. The common learning agents work in the search way of traditional SCO, chaotic learning agents search via chaotic search （CS） algorithm based on tent map which helps to avoid the premature convergence, elite learning agents search via elitist selection which helps to improve the global searching performance. Additionally, a chaotic search process is incorporated into local searching operation so as to enhance the local searching efficiency in the neighboring areas of the feasible solutions. Simulation results on a set of benchmark problems show that the proposed algorithm has high optimization efficiency, good global performance, and stable optimization outcomes for constrained NLPs.展开更多
Although anti-thrombotic therapy has been successful for prevention of deaths from acute myocardial infarction(MI),by far,there are few preventive and therapeutic options for ischemic heart failure(IHF)after MI.Qi-Tai...Although anti-thrombotic therapy has been successful for prevention of deaths from acute myocardial infarction(MI),by far,there are few preventive and therapeutic options for ischemic heart failure(IHF)after MI.Qi-Tai-Suan(QTS)is an oleanolic acid(OA)derivative which once underwent a clinical trial for treating hepatitis.In this study,we investigated the potential cardioprotective effect of QTS on IHF.IHF mouse model was constructed by coronary artery ligation in male C57BL/6J mice,and the protective effects of QTS on IHF were examined by echocardiography measurement,histological and TUNEL analysis,etc.We found that QTS exhibited promising cardioprotective effect on IHF.QTS treatment significantly improved cardiac function of IHF mice and the symptoms of heart failure.Notably,QTS had much better oral bioavailability(F=41.91%)in mice than its parent drug OA,and took effects mainly as its original form.Mechanistically,QTS ameliorated ischemic heart failure likely through suppression of cardiac apoptosis,inflammation and fibrosis.Taken together,QTS holds great promise as a preventive and therapeutic agent for ischemic heart failure and related diseases.展开更多
基金supported by the National Basic Research Program of China (2011CB311802)the National Natural Science Foundation of China (611721701, 61050003, 61105064)+2 种基金the Natural Science Foundation of Shaanxi Province (2011JM8007)the Open Science Foundation of Education Ministry Key Laboratory (IPIU012011007)the Scientific Research Program of Shaanxi Provincial Education Department (12JK0732, 11JK1037)
文摘To improve the global convergence speed of social cognitive optimization （SCO） algorithm, a hybrid social cognitive optimization （HSCO） algorithm based on elitist strategy and chaotic optimization is proposed to solve constrained nonlinear programming problems （NLPs）. The proposed algorithm partitions learning agents into three groups in proportion： elite learning agents, chaotic learning agents and common learning agents. The common learning agents work in the search way of traditional SCO, chaotic learning agents search via chaotic search （CS） algorithm based on tent map which helps to avoid the premature convergence, elite learning agents search via elitist selection which helps to improve the global searching performance. Additionally, a chaotic search process is incorporated into local searching operation so as to enhance the local searching efficiency in the neighboring areas of the feasible solutions. Simulation results on a set of benchmark problems show that the proposed algorithm has high optimization efficiency, good global performance, and stable optimization outcomes for constrained NLPs.
基金This program was financially supported by the National Natural Science Foundation of China(Nos.81730094 and 91853125).
文摘Although anti-thrombotic therapy has been successful for prevention of deaths from acute myocardial infarction(MI),by far,there are few preventive and therapeutic options for ischemic heart failure(IHF)after MI.Qi-Tai-Suan(QTS)is an oleanolic acid(OA)derivative which once underwent a clinical trial for treating hepatitis.In this study,we investigated the potential cardioprotective effect of QTS on IHF.IHF mouse model was constructed by coronary artery ligation in male C57BL/6J mice,and the protective effects of QTS on IHF were examined by echocardiography measurement,histological and TUNEL analysis,etc.We found that QTS exhibited promising cardioprotective effect on IHF.QTS treatment significantly improved cardiac function of IHF mice and the symptoms of heart failure.Notably,QTS had much better oral bioavailability(F=41.91%)in mice than its parent drug OA,and took effects mainly as its original form.Mechanistically,QTS ameliorated ischemic heart failure likely through suppression of cardiac apoptosis,inflammation and fibrosis.Taken together,QTS holds great promise as a preventive and therapeutic agent for ischemic heart failure and related diseases.
