Bioinformatics Analysis of the Relationship between Lifestyle and Prostate Cancer

In this study,we assessed the relationship between lifestyle and prostate cancer.We selected the Gene Expression Omnibus(GEO)dataset GSE10306 to analyze the expression levels of ataxin10(ATXN10),interferon related developmental regulator 1(IFRD1),formin-binding protein 1 like(FNBP1 L)and THO complex 2(THOC2)in prostate biopsies pre and post intensive nutrition and lifestyle intervention.Following a three-month intervention of nutrition and lifestyle,these genes showed a significant down-regulation.ONCOMINE database analysis showed that the four genes exhibited high expression in prostate cancer tissues compared with normal prostate tissues,which indicated that comprehensive lifestyle changes may modify the progression of prostate cancer mediated by altering the expression of ATXN10,FNBP1 L,THOC2 and IFRD1.Among the four genes,the high expression of IFRD1 was found to indicate a worse overall survival(OS)and disease-free survival(DFS).FNBP1 L and THOC2 were associated with CD8+T cell infiltration of prostate cancer.We also speculated a possible regulatory network for lifestyle to influence miRNA,subsequently influencing the expression of relevant genes.Our findings suggested that these genes may be used as potential target sites for the treatment of prostate cancer.