Objective To explore the difference of low-frequency electroacupuncture in regulating serum leptin and neuropeptide Y（NPY） of male and female patients with simple obesity due to spleen deficiency and damp exuberance...Objective To explore the difference of low-frequency electroacupuncture in regulating serum leptin and neuropeptide Y（NPY） of male and female patients with simple obesity due to spleen deficiency and damp exuberance. Methods Eighty patients with simple obesity, including 37 males and 43 females, were included in this study. In both groups（male group and female group）, Yīnlíngquán（阴陵泉 SP 9）, Sānyīnjiāo（三阴交 SP 6）, Zúsānlǐ（足三里 ST 36）, Fēnglóng（丰隆 ST 40）, Qūchí（曲池 LI 11）, Tiānshū（天枢 ST 25）, Zhōngwǎn（中脘 CV 12）, Shuǐfēn（水分 CV 9）, Qìhǎi（气海 CV 6）, and Guānyuán（关元 CV 4）. were selected, and low-frequency electroacupuncture treatment was applied. Needles were retained for 30 min. The treatment was conducted once a day, and 10 times were considered as one course of treatment. Two courses were needed. The changes of weight, BMI（body mass index）, F%（fat percentage） and serum leptin and NPY contents of patients in the two groups before and after treatment were observed and analyzed comparatively. Results After treatment, in male group, the weight lost（9.24±2.55） kg, BMI reduced by 4.19±2.30, F% reduced by 3.98±2.13, serum leptin level reduced by（0.66±0.23） ng/m L, and serum NPY level reduced by（18.56±2.89） pg/m L; in female group, the weight lost（6.77±2.31） kg, BMI reduced by 2.65±0.93, F% reduced by 4.98±2.30, serum leptin level reduced by（3.49±1.09） ng/m L, and serum NPY level reduced by（11.21±1.97） pg/m L. The results reduced significantly when compared with the level before treatment（P〈0.05, P〈0.01）. The loss of weight, BMI and serum NPY content in male group was more obvious than that in female group（all P〈0.01）, and the loss of F% and serum leptin content in female group was more obvious than that in male group（both P〈0.01）. Conclusion Low-frequency electroacupuncture can significantly regulate the weight, BMI, F% and serum leptin and NPY contents of male and female patients with simple obesity, and there are gender differences. In terms of reducing weight, BMI and serum NPY content, the efficacy of low-frequency electroacupuncture in males is superior to that in females, while in terms of reducing F% and serum leptin content, the efficacy in females is superior to that in males.展开更多
Objective： To investigate the effect of moxibustion at Shenque （CV 8） on free radical metabolism in rat＇s hippocampus after different degrees of exhaustive exercise. Methods： A total of 72 male Sprague-Dawley （S...Objective： To investigate the effect of moxibustion at Shenque （CV 8） on free radical metabolism in rat＇s hippocampus after different degrees of exhaustive exercise. Methods： A total of 72 male Sprague-Dawley （SD） rats were randomly divided into a normal group （n=8）, a model group （n=32） and a moxibustion group （n=32）. According to the times of modeling or treatment, the model group was further randomly divided into different subgroups of a 1-time model subgroup, a 4-time model subgroup, a 7-time model subgroup and a 10-time model subgroup （n=8）; the moxibustion group was also further randomly divided into different subgroups of a 1-time moxibustion subgroup, a 4-time moxibustion subgroup, a 7-time moxibustion subgroup and a 10-time moxibustion subgroup （n=8）. Rats in both model and moxibustion subgroups were subjected to establishing the swimming exhaustive model. Rats in each moxibustion subgroup received mild moxibustion at Shenque （CV 8） for 15 min immediately after modeling, once every other day. The concentration of malic dialdehyde （MDA）, as well as the activities of superoxide dismutase （SOD）, glutathione peroxidase （GSH-Px） and total antioxidant capacity （T-AOC） in rat＇s hippocampus in each group were detected 24 h after the exhaustive exercise. Results： Compared with the 1-time model subgroup, the exhaustive swimming time of rats was significantly prolonged in the 4-time model subgroup （P〈0.01）, while it was significantly shortened in the 7-time and 10-time model subgroups （both P〈0.01）. Compared with the matched model subgroup, the exhaustive swimming time of rats in the 7-time and 10-time moxibustion subgroups was significantly prolonged （both P〈0.01）. Compared with the normal group, the MDA concentration was increased significantly （P〈0.01）, and the activities stress response of SOD and T-AOC were increased in the 1-time model subgroup （both P〈0.05）; the MDA concentration was increased （all P〈0.01）, and the activities of SOD, GSH-Px and T-AOC were decreased differently （P〈0.05 or P〈0.01） in the 4-time, 7-time and 10-time model subgroups. Compared with the matched model subgroup, the concentration of MDA was significantly reduced （P〈0.05 or P〈0.01）, and the activities of SOD, GSH-Px and T-AOC were significantly increased in the 4-time, 7-time and 10-time moxibustion subgroups （all P〈0.01）. Conclusion： Moxibustion at Shenque （CV 8） can improve the fatigue status of the body after long-term exhaustive exercise by regulating free radical metabolism in rat＇s hippocampus. To some extent, this provides an experimental basis for moxibustion at Shenque （CV 8） against exercise-induced fatigue.展开更多
Objective:To investigate the effect of moxibustion at Shenque(CV 8)on fatigue in rats with chronic exercise-induced exhaustion.Methods:Thirty male Sprague-Dawley(SD)rats were randomly divided into a blank group,a mode...Objective:To investigate the effect of moxibustion at Shenque(CV 8)on fatigue in rats with chronic exercise-induced exhaustion.Methods:Thirty male Sprague-Dawley(SD)rats were randomly divided into a blank group,a model group and a moxibustion group,10 rats in each group.Except rats in the blank group,the remaining rats were subjected to create long-term exhaustion models by repeated swimming.After successful modeling,rats in the moxibustion group received mild moxibustion at Shenque(CV 8)for 15 min,once every other day with a total of 10 times.Rats in the model group and the blank group did not receive moxibustion.At the end of the treatment,the exhausted times,and the body weight of rats before and after the experiment were compared among groups.The levels of blood malondialdehyde(MDA)and urea nitrogen(BUN),as well as the activities of aspartate transarninase(AST),alanine aminotransferase(ALT)and lactate dehydrogenase(LDH)were also measured by the automatic biochemical analyzer,24 h after the exhausting excise.Results:The 10 th swimming time was significantly longer in the moxibustion group than that in the model group(P〈0.01).The increase rate of the body weight was lower in the rats of the moxibustion group than that in the model group before the 7 th and the 10 th exhausting excise(P〈0.05,P〈0.01).The levels of serum MDA and BUN,as well as the activities of AST,ALT and LDH in the model group were higher than those in the blank group(all P〈0.01).The levels of serum MDA and BUN,as well as the activities of AST,ALT and LDH in the moxibustion group were lower than those in the model group(P〈0.01).Conclusion:Moxibustion at Shenque(CV 8)can decrease the serum levels of MDA and BUN,as well as activities of AST,ALT and LDH in the long-term fatigue rats,thus to improve the symptoms of fatigue.展开更多
Objective:To observe the difference of the effect of low-frequency electroacupuncture(EA)on blood lipids between male and female patients with simple obesity due to damp induced by spleen deficiency.Methods:Eighty pat...Objective:To observe the difference of the effect of low-frequency electroacupuncture(EA)on blood lipids between male and female patients with simple obesity due to damp induced by spleen deficiency.Methods:Eighty patients with simple obesity were recruited,including 37 males and 43 females,to receive low-frequency EA by selecting Yinlingquan(SP 10),Sanyinjiao(SP 6),Zusanli(ST 36),Fenglong(ST 40),Quchi(LI 11),Tianshu(ST 25),Zhongwan(CV 12),Shuifen(CV 9),Qihai(CV 6)and Guanyuan(CV 4),with needles retained for 30 min.The treatment was given once a day,10 sessions as a treatment course,for 2 courses in total.The contents of body fat percentage(F%),total cholesterol(TC),triglyceride(TG),high-density lipoprotein(HDL),low-density lipoprotein(LDL),blood glucose(Glu)and adiponectin(ADPN)in serum were observed to see the changes,and the two groups were compared and analyzed.Results:After the treatment,F%,and serum contents of TC,TG,LDL,Glu and ADPN dropped significantly in the two groups(P〈0.05 or P〈0.01)and the serum content of HDL increased significantly in male group(P〈0.05).The decrease of F%in female group was more significant than that in male group(P〈0.01);the decrease of ADPN in male group was more significant than that in female group(P〈0.05).Conclusion:EA can regulate the disordered blood lipids in male and female patients with simple obesity,with certain differences between genders.The decrease of subcutaneous fat content is more significant in females than that in males,while the decrease of ADPN is more significant in males.展开更多
基金Supported by Science-technology support project of Hebei Provincial Administration of Traditional Chinese Medicine:2014015Youth fund project of Hebei University of Chinese Medicine:QNZ2014023
文摘Objective To explore the difference of low-frequency electroacupuncture in regulating serum leptin and neuropeptide Y（NPY） of male and female patients with simple obesity due to spleen deficiency and damp exuberance. Methods Eighty patients with simple obesity, including 37 males and 43 females, were included in this study. In both groups（male group and female group）, Yīnlíngquán（阴陵泉 SP 9）, Sānyīnjiāo（三阴交 SP 6）, Zúsānlǐ（足三里 ST 36）, Fēnglóng（丰隆 ST 40）, Qūchí（曲池 LI 11）, Tiānshū（天枢 ST 25）, Zhōngwǎn（中脘 CV 12）, Shuǐfēn（水分 CV 9）, Qìhǎi（气海 CV 6）, and Guānyuán（关元 CV 4）. were selected, and low-frequency electroacupuncture treatment was applied. Needles were retained for 30 min. The treatment was conducted once a day, and 10 times were considered as one course of treatment. Two courses were needed. The changes of weight, BMI（body mass index）, F%（fat percentage） and serum leptin and NPY contents of patients in the two groups before and after treatment were observed and analyzed comparatively. Results After treatment, in male group, the weight lost（9.24±2.55） kg, BMI reduced by 4.19±2.30, F% reduced by 3.98±2.13, serum leptin level reduced by（0.66±0.23） ng/m L, and serum NPY level reduced by（18.56±2.89） pg/m L; in female group, the weight lost（6.77±2.31） kg, BMI reduced by 2.65±0.93, F% reduced by 4.98±2.30, serum leptin level reduced by（3.49±1.09） ng/m L, and serum NPY level reduced by（11.21±1.97） pg/m L. The results reduced significantly when compared with the level before treatment（P〈0.05, P〈0.01）. The loss of weight, BMI and serum NPY content in male group was more obvious than that in female group（all P〈0.01）, and the loss of F% and serum leptin content in female group was more obvious than that in male group（both P〈0.01）. Conclusion Low-frequency electroacupuncture can significantly regulate the weight, BMI, F% and serum leptin and NPY contents of male and female patients with simple obesity, and there are gender differences. In terms of reducing weight, BMI and serum NPY content, the efficacy of low-frequency electroacupuncture in males is superior to that in females, while in terms of reducing F% and serum leptin content, the efficacy in females is superior to that in males.
文摘Objective： To investigate the effect of moxibustion at Shenque （CV 8） on free radical metabolism in rat＇s hippocampus after different degrees of exhaustive exercise. Methods： A total of 72 male Sprague-Dawley （SD） rats were randomly divided into a normal group （n=8）, a model group （n=32） and a moxibustion group （n=32）. According to the times of modeling or treatment, the model group was further randomly divided into different subgroups of a 1-time model subgroup, a 4-time model subgroup, a 7-time model subgroup and a 10-time model subgroup （n=8）; the moxibustion group was also further randomly divided into different subgroups of a 1-time moxibustion subgroup, a 4-time moxibustion subgroup, a 7-time moxibustion subgroup and a 10-time moxibustion subgroup （n=8）. Rats in both model and moxibustion subgroups were subjected to establishing the swimming exhaustive model. Rats in each moxibustion subgroup received mild moxibustion at Shenque （CV 8） for 15 min immediately after modeling, once every other day. The concentration of malic dialdehyde （MDA）, as well as the activities of superoxide dismutase （SOD）, glutathione peroxidase （GSH-Px） and total antioxidant capacity （T-AOC） in rat＇s hippocampus in each group were detected 24 h after the exhaustive exercise. Results： Compared with the 1-time model subgroup, the exhaustive swimming time of rats was significantly prolonged in the 4-time model subgroup （P〈0.01）, while it was significantly shortened in the 7-time and 10-time model subgroups （both P〈0.01）. Compared with the matched model subgroup, the exhaustive swimming time of rats in the 7-time and 10-time moxibustion subgroups was significantly prolonged （both P〈0.01）. Compared with the normal group, the MDA concentration was increased significantly （P〈0.01）, and the activities stress response of SOD and T-AOC were increased in the 1-time model subgroup （both P〈0.05）; the MDA concentration was increased （all P〈0.01）, and the activities of SOD, GSH-Px and T-AOC were decreased differently （P〈0.05 or P〈0.01） in the 4-time, 7-time and 10-time model subgroups. Compared with the matched model subgroup, the concentration of MDA was significantly reduced （P〈0.05 or P〈0.01）, and the activities of SOD, GSH-Px and T-AOC were significantly increased in the 4-time, 7-time and 10-time moxibustion subgroups （all P〈0.01）. Conclusion： Moxibustion at Shenque （CV 8） can improve the fatigue status of the body after long-term exhaustive exercise by regulating free radical metabolism in rat＇s hippocampus. To some extent, this provides an experimental basis for moxibustion at Shenque （CV 8） against exercise-induced fatigue.
文摘Objective:To investigate the effect of moxibustion at Shenque(CV 8)on fatigue in rats with chronic exercise-induced exhaustion.Methods:Thirty male Sprague-Dawley(SD)rats were randomly divided into a blank group,a model group and a moxibustion group,10 rats in each group.Except rats in the blank group,the remaining rats were subjected to create long-term exhaustion models by repeated swimming.After successful modeling,rats in the moxibustion group received mild moxibustion at Shenque(CV 8)for 15 min,once every other day with a total of 10 times.Rats in the model group and the blank group did not receive moxibustion.At the end of the treatment,the exhausted times,and the body weight of rats before and after the experiment were compared among groups.The levels of blood malondialdehyde(MDA)and urea nitrogen(BUN),as well as the activities of aspartate transarninase(AST),alanine aminotransferase(ALT)and lactate dehydrogenase(LDH)were also measured by the automatic biochemical analyzer,24 h after the exhausting excise.Results:The 10 th swimming time was significantly longer in the moxibustion group than that in the model group(P〈0.01).The increase rate of the body weight was lower in the rats of the moxibustion group than that in the model group before the 7 th and the 10 th exhausting excise(P〈0.05,P〈0.01).The levels of serum MDA and BUN,as well as the activities of AST,ALT and LDH in the model group were higher than those in the blank group(all P〈0.01).The levels of serum MDA and BUN,as well as the activities of AST,ALT and LDH in the moxibustion group were lower than those in the model group(P〈0.01).Conclusion:Moxibustion at Shenque(CV 8)can decrease the serum levels of MDA and BUN,as well as activities of AST,ALT and LDH in the long-term fatigue rats,thus to improve the symptoms of fatigue.
文摘Objective:To observe the difference of the effect of low-frequency electroacupuncture(EA)on blood lipids between male and female patients with simple obesity due to damp induced by spleen deficiency.Methods:Eighty patients with simple obesity were recruited,including 37 males and 43 females,to receive low-frequency EA by selecting Yinlingquan(SP 10),Sanyinjiao(SP 6),Zusanli(ST 36),Fenglong(ST 40),Quchi(LI 11),Tianshu(ST 25),Zhongwan(CV 12),Shuifen(CV 9),Qihai(CV 6)and Guanyuan(CV 4),with needles retained for 30 min.The treatment was given once a day,10 sessions as a treatment course,for 2 courses in total.The contents of body fat percentage(F%),total cholesterol(TC),triglyceride(TG),high-density lipoprotein(HDL),low-density lipoprotein(LDL),blood glucose(Glu)and adiponectin(ADPN)in serum were observed to see the changes,and the two groups were compared and analyzed.Results:After the treatment,F%,and serum contents of TC,TG,LDL,Glu and ADPN dropped significantly in the two groups(P〈0.05 or P〈0.01)and the serum content of HDL increased significantly in male group(P〈0.05).The decrease of F%in female group was more significant than that in male group(P〈0.01);the decrease of ADPN in male group was more significant than that in female group(P〈0.05).Conclusion:EA can regulate the disordered blood lipids in male and female patients with simple obesity,with certain differences between genders.The decrease of subcutaneous fat content is more significant in females than that in males,while the decrease of ADPN is more significant in males.
