A Fuzzy Cluster and Retinex Theory-based Variation Model for Inhomogenous Image Segmentation

A variational inhomogeneous image segmentation model based on fuzzy membership functions and Retinex theory is proposed by introducing the fuzzy membership function.The existence of the solution of the proposed model is proved theoretically.A valid algorithm is designed to make numerical solution of the model under the framework of alternating minimization.The last experimental results show that the model can make segmentation of the real image with intensity inhomogeneity effectively.

Box-Behnken法优化渗透泵微丸丸芯的制备工艺

目的:优化渗透泵微丸丸芯的处方、制备工艺,为渗透泵载药微丸研究提供优质丸芯。方法:在单因素的基础上,以休止角、硬度为评价指标,采用Box-Behnken法优选渗透丸芯的最佳制备工艺。结果:由单因素试验及Box-Behnken试验可知,以乳糖-微晶纤维素-PVP(5∶1∶0.1,w/w)为丸芯组成,以挤出转速30r·min^(-1),挤出温度24℃,滚圆转速1 800r·min^(-1)为最佳制备工艺,制得粒径为0.8mm,休止角为28.42°,硬度为17.52kg·cm-2的丸芯。结论:本实验筛选出渗透泵丸芯的处方组成及制备工艺,可为以渗透压为动力的渗透泵丸芯的制备研究提供参考。