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Influences of Cu or Cd on the neurotoxicity induced by petroleum hydrocarbons in ragworm Perinereis aibuhitensis 被引量:12
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作者 ZHANG Qianru ZHOU Qixing +3 位作者 WANG Jing sun shulan HUA Tao REN Liping 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2008年第3期364-371,共8页
The ecotoxicological effects of heavy metals and petroleum hydrocarbons (PHCs) on ragworms are still vague. The relationships between toxicological indices (mortality and acetylcholinesterase (ACHE) activity) an... The ecotoxicological effects of heavy metals and petroleum hydrocarbons (PHCs) on ragworms are still vague. The relationships between toxicological indices (mortality and acetylcholinesterase (ACHE) activity) and concentrations of toxicants (Cu, Cd, and PHCs) were examined in the estuary keystone species Perinereis aibuhitensis in laboratory conditions. The results of single toxicant indicated that three toxicants had potentially physiological toxicity to P. aibuhitensis. The estimated 4-d and 10-d LC50 for Cu, Cd, and PHCs was derived from the relationships between mortality and toxicants concentrations. Notable changes in the morphological signs and symptoms of P. aibuhitensis exposed to PHCs were observed. The ACHE activity of P. aibuhitensis was more sensitive to the toxicity of PHCs than the others. The results of combined toxicants implied that the combined toxicity of Cu or Cd and PHCs to P. aibuhitensis was related to the concentration combination of toxicants. Compared to single PHCs treatment, the addition of Cu or Cd significantly mitigated the neurotoxicity of PHCs to ACHE activity in P. aibuhitensis, which showed an antagonistic effect. 展开更多
关键词 acetylcholinesterase (ACHE) Perinereis aibuhitensis CU CD petroleum hydrocarbons
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宫颈癌患者与健康人群血常规指标比较 被引量:7
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作者 苏楠 李晓曦 +3 位作者 孙舒岚 许梦丹 廖一鸣 张桂荣 《现代肿瘤医学》 CAS 2018年第6期924-927,共4页
目的:对未经过任何治疗的初诊宫颈癌患者与健康人群血常规中白细胞计数、中性粒细胞计数、淋巴细胞计数、血小板计数、中性粒细胞-淋巴细胞比率(the neutrophil-to-lymphocyte ratio,NLR)及血小板-淋巴细胞比率(the platelet-to-lymphoc... 目的:对未经过任何治疗的初诊宫颈癌患者与健康人群血常规中白细胞计数、中性粒细胞计数、淋巴细胞计数、血小板计数、中性粒细胞-淋巴细胞比率(the neutrophil-to-lymphocyte ratio,NLR)及血小板-淋巴细胞比率(the platelet-to-lymphocyte,PLR)进行比较,探讨各项指标在宫颈癌发生中的意义。方法:收集2013年1月至12月期间,于我院接受手术治疗的151名宫颈癌患者的初次检查血常规结果及病理资料,同时收集同年在我院体检中心接受健康体检人群的血常规结果。以宫颈癌患者年龄为基础,与健康人群进行1∶1配对。对两组人群血常规结果中的白细胞计数、中性粒细胞计数、淋巴细胞计数、血小板计数进行配对t检验分析,对通过计算得到的NLR及PLR进行配对秩和检验。结果:宫颈癌组白细胞计数、中性粒细胞计数、血小板计数、NLR值和PLR值均高于健康对照组(P<0.05)。而宫颈癌组淋巴细胞计数明显低于健康对照组(P<0.05)。以上血常规指标在年龄分组中均呈现相同趋势。随着肿瘤罹患,白细胞、中性粒细胞、血小板、NLR值及PLR值均升高,而淋巴细胞计数下降。结论:宫颈癌的发生与免疫状态低下和炎症反应有关,NLR和PLR可能成为宫颈癌的早诊指标。 展开更多
关键词 白细胞 淋巴细胞计数 中性粒细胞-淋巴细胞比率 血小板-淋巴细胞比率 宫颈
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双歧杆菌三联活菌辅助蓝光照射治疗新生儿黄疸的临床疗效 被引量:3
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作者 孙淑兰 《当代医学》 2022年第10期168-170,共3页
目的探究双歧杆菌三联活菌辅助蓝光照射治疗新生儿黄疸的临床疗效。方法选取本院2019年6月至2020年6月收治的100例新生儿黄疸患儿作为研究对象,随机分为对照组与观察组,每组50例。对照组采用蓝光照射法治疗,观察组在对照组基础上联合双... 目的探究双歧杆菌三联活菌辅助蓝光照射治疗新生儿黄疸的临床疗效。方法选取本院2019年6月至2020年6月收治的100例新生儿黄疸患儿作为研究对象,随机分为对照组与观察组,每组50例。对照组采用蓝光照射法治疗,观察组在对照组基础上联合双歧杆菌三联活菌治疗。比较两组临床疗效、治疗前后胆红素相关指标及不良反应发生率。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组总胆红素(TSB)、直接胆红素(DB)及经皮胆红素(TCB)均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组不良反应率为12.00%,明显低于对照组的54.00%,差异有统计学意义(P<0.05)。结论双歧杆菌三联活菌辅助蓝光照射治疗新生儿黄疸效果显著,可提高临床疗效,减少不良反应发生率,降低总胆红素、直接胆红素及经皮胆红素水平,值得临床推广应用。 展开更多
关键词 双歧杆菌三联活菌 蓝光照射 新生儿黄疸
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Characterization of a new mutant allele of the Arabidopsis Flowering Locus D (FLD) gene that controls theflowering time by repressing FLC 被引量:6
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作者 CHEN Ruiqiang ZHANG Suzhi +2 位作者 sun shulan CHANG Jianhong ZUO Jianru 《Chinese Science Bulletin》 SCIE EI CAS 2005年第23期2701-2706,共6页
Flowering in higher plants is controlled by both the internal and environmental cues. In Arabidopsis, several major genetic loci have been defined as the key switches to control flowering. The Flowering Locus C (FLC) ... Flowering in higher plants is controlled by both the internal and environmental cues. In Arabidopsis, several major genetic loci have been defined as the key switches to control flowering. The Flowering Locus C (FLC) gene has been shown in the autonomous pathway to inhibit the vege-tative-to-reproductive transition. FLC appears to be re-pressed by Flowering Locus D (FLD), which encodes a com-ponent of the histone deacetylase complex. Here we report the identification and characterization of a new mutant allele fld-5. Genetic analysis indicates that fld-5 (in the Was-silewskija background) is allelic to the previously character-ized fld-3 and fld-4 (in the Colombia-0 background). Genetic and molecular analyses reveal that fld-5 carries a frame-shift mutation, resulting in a premature termination of the FLD open reading frame. The FLC expression is remarkably in-creased in fld-5, which presumably attributes to the ex-tremely delayed flowering phenotype of the mutant. 展开更多
关键词 阿布属 开花基因位点 突变等位基因 植物遗传学 开花时间控制
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