Introduction Although devices based on pseudorotaxanes, cantenanes, and rotaxanes are commercialized yet, several researches have been done on the applications of these donor-acceptor molecules. A promising area is t...Introduction Although devices based on pseudorotaxanes, cantenanes, and rotaxanes are commercialized yet, several researches have been done on the applications of these donor-acceptor molecules. A promising area is the field of nanotechnology. The miniaturization of semi-conductor technology by the ＂top-down＂ approach is limited by the wavelength of the radiation used in the lithography to prepare electronic components. Therefore, the ＂bottom-up＂ may be more suitable to create devices with sizes down to the molecular level. A molecular or supramolecular system, in which the relative position of the component parts can be altered by an external stimulus, a molecular switch, can act as the basic unit for the creation of new molecular devices .展开更多
A quasi-rectangular waveguide polymer MacH^(-)Zehnder (M-Z) electro-optic (EO) modulator based on an organic/inorganic hybrid material with thermal bias control is fabricated and demonstrated.Linear bias for the modul...A quasi-rectangular waveguide polymer MacH^(-)Zehnder (M-Z) electro-optic (EO) modulator based on an organic/inorganic hybrid material with thermal bias control is fabricated and demonstrated.Linear bias for the modulator is obtained through thermo-optic effect.The optical output is adjusted by changing phase difference between the two arms of the M-Z interferometer.A power consumption of 16.1 m W for π phase change is observed owing to the application of silica cladding.This approach is proved to be effective to suppress direct current drift in polymer EO modulators.展开更多
目的了解宁夏2020年流感病原学检测情况,分析H3N2流感病毒神经氨酸酶(neuraminidase,NA)基因特征及对奥斯他韦和扎那米韦的药物敏感性。方法采集2020年宁夏9家国家级流感监测哨点医院流感样病例标本,采用real time RT-PCR方法进行核酸检...目的了解宁夏2020年流感病原学检测情况,分析H3N2流感病毒神经氨酸酶(neuraminidase,NA)基因特征及对奥斯他韦和扎那米韦的药物敏感性。方法采集2020年宁夏9家国家级流感监测哨点医院流感样病例标本,采用real time RT-PCR方法进行核酸检测,阳性标本用狗肾细胞(MDCK)进行病毒分离;分离的H3N2流感毒株进行NA基因序列测定,利用生物信息软件对测序结果进行比对,分析变异和耐药位点;通过神经氨酸酶抑制(NAI)实验,分析H3N2流感病毒耐药情况。结果2020年宁夏采集咽拭子标本共6479份,核酸检测阳性数为273份,阳性率为4.21%,其中H3N2流感阳性数为178份,占总阳性数的65.20%,分离H3N2流感毒株26株。H3N2流感毒株NA蛋白酶活性中心及周围相关位点未发生变异;与疫苗株A/Kansas/14/2017(H3N2)比较,A/Ningxia-Yuanzhou/1116/2020(H3N2)和A/Ningxia-Yuanzhou/133/2020(H3N2)毒株发生T329N、N339D变异,增加1个潜在糖基化位点NDS329~331;其余24株NA蛋白抗原决定簇位点发生T329S变异,潜在糖基化位点与疫苗株一致共有8个;二硫键未发生变异。26株H3N2流感毒株间的NA基因核苷酸同源性为98.7%~100%,与疫苗株A/Kansas/14/2017(H3N2)的核苷酸同源性为98.1%~98.9%,宁夏毒株属3C.2a.1分支。26株H3N2流感毒株NA蛋白耐药位点未发生变异。26株对奥斯他韦敏的IC50值均<13.05;对扎那米韦的IC50值均<2.488。结论宁夏2020年流感优势毒株为H3N2流感毒株。NA蛋白序列发生了不同程度的变异。宁夏H3N2流感病毒对奥斯他韦和扎那米韦均敏感,可以继续使用此类药物进行H3N2流感病毒感染患者的临床治疗。展开更多
基金Supported by the National Natural Science Foundation of China(No.20272019).
文摘Introduction Although devices based on pseudorotaxanes, cantenanes, and rotaxanes are commercialized yet, several researches have been done on the applications of these donor-acceptor molecules. A promising area is the field of nanotechnology. The miniaturization of semi-conductor technology by the ＂top-down＂ approach is limited by the wavelength of the radiation used in the lithography to prepare electronic components. Therefore, the ＂bottom-up＂ may be more suitable to create devices with sizes down to the molecular level. A molecular or supramolecular system, in which the relative position of the component parts can be altered by an external stimulus, a molecular switch, can act as the basic unit for the creation of new molecular devices .
基金Supported by the National Natural Science Foundation of China under Grant Nos 61107019,61077041,61177027 and 60807029the Program for Special Funds of Basic Science&Technology of Jilin University under Grant Nos 201103071,201100253 and 200905005+1 种基金Science Foundation for Young Scientists of Jilin Province(No 20100174)Science and Technology Development Plan of Jilin Province(No 20110315).
文摘A quasi-rectangular waveguide polymer MacH^(-)Zehnder (M-Z) electro-optic (EO) modulator based on an organic/inorganic hybrid material with thermal bias control is fabricated and demonstrated.Linear bias for the modulator is obtained through thermo-optic effect.The optical output is adjusted by changing phase difference between the two arms of the M-Z interferometer.A power consumption of 16.1 m W for π phase change is observed owing to the application of silica cladding.This approach is proved to be effective to suppress direct current drift in polymer EO modulators.
文摘目的了解宁夏2020年流感病原学检测情况,分析H3N2流感病毒神经氨酸酶(neuraminidase,NA)基因特征及对奥斯他韦和扎那米韦的药物敏感性。方法采集2020年宁夏9家国家级流感监测哨点医院流感样病例标本,采用real time RT-PCR方法进行核酸检测,阳性标本用狗肾细胞(MDCK)进行病毒分离;分离的H3N2流感毒株进行NA基因序列测定,利用生物信息软件对测序结果进行比对,分析变异和耐药位点;通过神经氨酸酶抑制(NAI)实验,分析H3N2流感病毒耐药情况。结果2020年宁夏采集咽拭子标本共6479份,核酸检测阳性数为273份,阳性率为4.21%,其中H3N2流感阳性数为178份,占总阳性数的65.20%,分离H3N2流感毒株26株。H3N2流感毒株NA蛋白酶活性中心及周围相关位点未发生变异;与疫苗株A/Kansas/14/2017(H3N2)比较,A/Ningxia-Yuanzhou/1116/2020(H3N2)和A/Ningxia-Yuanzhou/133/2020(H3N2)毒株发生T329N、N339D变异,增加1个潜在糖基化位点NDS329~331;其余24株NA蛋白抗原决定簇位点发生T329S变异,潜在糖基化位点与疫苗株一致共有8个;二硫键未发生变异。26株H3N2流感毒株间的NA基因核苷酸同源性为98.7%~100%,与疫苗株A/Kansas/14/2017(H3N2)的核苷酸同源性为98.1%~98.9%,宁夏毒株属3C.2a.1分支。26株H3N2流感毒株NA蛋白耐药位点未发生变异。26株对奥斯他韦敏的IC50值均<13.05;对扎那米韦的IC50值均<2.488。结论宁夏2020年流感优势毒株为H3N2流感毒株。NA蛋白序列发生了不同程度的变异。宁夏H3N2流感病毒对奥斯他韦和扎那米韦均敏感,可以继续使用此类药物进行H3N2流感病毒感染患者的临床治疗。
