Objective: To investigate whether Naoxueshu Oral Liquid(NXS) could promote hematoma absorption in post-craniotomy hematoma(PCH) patients. Methods: This is an open-label, multicenter, and randomized controlled trial co...Objective: To investigate whether Naoxueshu Oral Liquid(NXS) could promote hematoma absorption in post-craniotomy hematoma(PCH) patients. Methods: This is an open-label, multicenter, and randomized controlled trial conducted at 9 hospitals in China. Patients aged 18–80 years with post-craniotomy supratentorial hematoma volume ranging from 10 to 30 mL or post-craniotomy infratentorial hematoma volume less than 10 mL, or intraventricular hemorrhage following cranial surgery were enrolled. They were randomly assigned at a 1:1 ratio to the NXS(10 m L thrice daily for 15 days) or control groups using a randomization code table. Standard medical care was administered in both groups. The primary outcome was the percentage reduction in hematoma volume from day 1 to day 15. The secondary outcomes included the percentage reduction in hematoma volume from day 1 to day 7, the absolute reduction in hematoma volume from day 1 to day 7 and 15, and the change in neurological function from day 1 to day 7 and 15. The safety was closely monitored throughout the study. Moreover, subgroup analysis was performed based on age, gender, history of diabetes, and etiology of intracerebral hemorrhage(ICH). Results: A total of 120 patients were enrolled and randomly assigned between March 30, 2018 and April 15, 2020. One patient was lost to follow-up in the control group. Finally, there were 119 patients(60 in the NXS group and 59 in the control group) included in the analysis. In the full analysis set(FAS) analysis, the NXS group had a greater percentage reduction in hematoma volume from day 1 to day 15 than the control group [median(Q1, Q3): 85%(71%, 97%) vs. 76%(53%, 93%), P<0.05]. The secondary outcomes showed no statistical significance between two groups, either in FAS or per-protocol set(P>0.05). Furthermore, no adverse events were reported during the study. In the FAS analysis, the NXS group exhibited a higher percentage reduction in hematoma volume on day 15 in the following subgroups: male patients, patients younger than 65 years, patients without diabetes, or those with initial cranial surgery due to ICH(all P<0.05). Conclusions: The administration of NXS demonstrated the potential to promote the percentage reduction in hematoma volume from day 1 to day 15. This intervention was found to be safe and feasible. The response to NXS may be influenced by patient characteristics.展开更多
Network virtualization is a promising way to overcome the current ossification of the Intemet. It is essential challenge to find effective, efficient and robust embedding algorithms for recovering virtual network. The...Network virtualization is a promising way to overcome the current ossification of the Intemet. It is essential challenge to find effective, efficient and robust embedding algorithms for recovering virtual network. The virtual network mapping algorithm based on integer programming which was proposed months ago. But it did consider the faults of physical network resources, which is so called survivable virtual network embedding （VNE） problem. Previous strategies for enabling survivability in network virtualization focused on providing protection for the physical network or enhancing the virtual networks by providing backup physical resources in advance, and treated all the physical failures as link failures. In the article, a dynamic recovery method is proposed to solve the survivable virtual network embedding problem based on the integer programming VNE algorithm. The dynamic recovery method doesn＇t need to backup physical resources and it makes more substrate resources which can be used in the embedding. The dynamic recovery process will be activated only when physical failures occur. Different algorithms are used to recovery node and link failures. Simulations show that the method helps to recover almost all of physical failures by finding the substitute nodes and paths, and its performance is very close to that of pure VNE method without considering physical failures.展开更多
基金Supported by the Technology Platform Construction Project of Fujian Province (No. 2021Y2001 and 2020Y2003)。
文摘Objective: To investigate whether Naoxueshu Oral Liquid(NXS) could promote hematoma absorption in post-craniotomy hematoma(PCH) patients. Methods: This is an open-label, multicenter, and randomized controlled trial conducted at 9 hospitals in China. Patients aged 18–80 years with post-craniotomy supratentorial hematoma volume ranging from 10 to 30 mL or post-craniotomy infratentorial hematoma volume less than 10 mL, or intraventricular hemorrhage following cranial surgery were enrolled. They were randomly assigned at a 1:1 ratio to the NXS(10 m L thrice daily for 15 days) or control groups using a randomization code table. Standard medical care was administered in both groups. The primary outcome was the percentage reduction in hematoma volume from day 1 to day 15. The secondary outcomes included the percentage reduction in hematoma volume from day 1 to day 7, the absolute reduction in hematoma volume from day 1 to day 7 and 15, and the change in neurological function from day 1 to day 7 and 15. The safety was closely monitored throughout the study. Moreover, subgroup analysis was performed based on age, gender, history of diabetes, and etiology of intracerebral hemorrhage(ICH). Results: A total of 120 patients were enrolled and randomly assigned between March 30, 2018 and April 15, 2020. One patient was lost to follow-up in the control group. Finally, there were 119 patients(60 in the NXS group and 59 in the control group) included in the analysis. In the full analysis set(FAS) analysis, the NXS group had a greater percentage reduction in hematoma volume from day 1 to day 15 than the control group [median(Q1, Q3): 85%(71%, 97%) vs. 76%(53%, 93%), P<0.05]. The secondary outcomes showed no statistical significance between two groups, either in FAS or per-protocol set(P>0.05). Furthermore, no adverse events were reported during the study. In the FAS analysis, the NXS group exhibited a higher percentage reduction in hematoma volume on day 15 in the following subgroups: male patients, patients younger than 65 years, patients without diabetes, or those with initial cranial surgery due to ICH(all P<0.05). Conclusions: The administration of NXS demonstrated the potential to promote the percentage reduction in hematoma volume from day 1 to day 15. This intervention was found to be safe and feasible. The response to NXS may be influenced by patient characteristics.
基金supported by the National Basic Research Programs of China(2012CB315801)
文摘Network virtualization is a promising way to overcome the current ossification of the Intemet. It is essential challenge to find effective, efficient and robust embedding algorithms for recovering virtual network. The virtual network mapping algorithm based on integer programming which was proposed months ago. But it did consider the faults of physical network resources, which is so called survivable virtual network embedding （VNE） problem. Previous strategies for enabling survivability in network virtualization focused on providing protection for the physical network or enhancing the virtual networks by providing backup physical resources in advance, and treated all the physical failures as link failures. In the article, a dynamic recovery method is proposed to solve the survivable virtual network embedding problem based on the integer programming VNE algorithm. The dynamic recovery method doesn＇t need to backup physical resources and it makes more substrate resources which can be used in the embedding. The dynamic recovery process will be activated only when physical failures occur. Different algorithms are used to recovery node and link failures. Simulations show that the method helps to recover almost all of physical failures by finding the substitute nodes and paths, and its performance is very close to that of pure VNE method without considering physical failures.
