Drimane-type sesquiterpenoids are widely distributed in fungi.From the ethyl acetate extract of the earwig-derived Aspergillus sp.NF2396,seven new drimane-type sesquiterpenoids,named drimanenoids A−G(1−7),were isolate...Drimane-type sesquiterpenoids are widely distributed in fungi.From the ethyl acetate extract of the earwig-derived Aspergillus sp.NF2396,seven new drimane-type sesquiterpenoids,named drimanenoids A−G(1−7),were isolated.Their structures were elucidated by diverse spectroscopic analysis including high-resolution ESI-MS,one-and two-dimensional NMR spectroscopy.Drimanenoids A−F(1−6)are new members of drimane-type sesquiterpenoid esterified with unsaturated fatty acid side chain at C-6.Drimanenoids C(3),D(4)and F(6)showed antibacterial activity against five types of bacteria with different inhibition diameters.Drimanenoid D(4)exhibited moderate cytotoxicity against human myelogenous leukemia cell line K562 with an IC_(50) value of 12.88±0.11μmol·L^(−1).展开更多
基金This work was supported by the Central Publicinterest Scientific Institution Basal Research Fund for CATAS-ITBB(Nos.1630052022016,1630052019011,and 19CXTD-32)the National Key Research and Development Program(No.2018YFA0902000)+1 种基金the National Natural Science Foundation of China(No.81991524)the Hainan Provincial Basic and Applied Basic Research Fund for High-Level Talents in Natural Science(Nos.2019RC306 and 2019RC352).
文摘Drimane-type sesquiterpenoids are widely distributed in fungi.From the ethyl acetate extract of the earwig-derived Aspergillus sp.NF2396,seven new drimane-type sesquiterpenoids,named drimanenoids A−G(1−7),were isolated.Their structures were elucidated by diverse spectroscopic analysis including high-resolution ESI-MS,one-and two-dimensional NMR spectroscopy.Drimanenoids A−F(1−6)are new members of drimane-type sesquiterpenoid esterified with unsaturated fatty acid side chain at C-6.Drimanenoids C(3),D(4)and F(6)showed antibacterial activity against five types of bacteria with different inhibition diameters.Drimanenoid D(4)exhibited moderate cytotoxicity against human myelogenous leukemia cell line K562 with an IC_(50) value of 12.88±0.11μmol·L^(−1).