Bladder cancer is among the most frequently diagnosed cancer. Tobacco smoking exposures involving nitrosamines and aromatic amines are the main cause of bladder cancer. Although cigarette consumption has gradually dec...Bladder cancer is among the most frequently diagnosed cancer. Tobacco smoking exposures involving nitrosamines and aromatic amines are the main cause of bladder cancer. Although cigarette consumption has gradually decreased, an increased incidence of bladder cancer was registered among males Tunisian for the last two decades. A similar increased incidence of lung adenocarcinoma and bladder cancer was registered among Tunisian males. Epidemiological results suggest that changes in cigarette smoking may be the cause of the increased incidence of bladder cancer. The relationship between CYP1A2 enzyme activities, a key enzyme for activation of bladder carcinogens, and bladder cancer risk was investigated. Variations in CYP1 A2 activities measured in patients with bladder cancer and healthy smokers showed a signifycantly higher CYP1A2 metabolic activity in patient group. Changing in cigarette smoking habits associated to the variation in CYP1A2 activity seem to explain partly the increase incidence of bladder cancer observed in Tunisian male population.展开更多
The present study investigated relationships between clozapine dose, clozapine and norclozapine plasma concentrations, and clinical responses to clozapine treatment in Tunisian schizophrenics. Fourteen schizophrenia-t...The present study investigated relationships between clozapine dose, clozapine and norclozapine plasma concentrations, and clinical responses to clozapine treatment in Tunisian schizophrenics. Fourteen schizophrenia-treatment resistant patients, recruited for this study, were treated with clozapine for 45 days. Patient health improvement was assessed before and after each cycle of two weeks of clozapine therapy, using the Brief Psychiatric Rating Scale (BPRS). Plasma clozapine and norclozapine concentrations were determined by high-performance liquid chromatography (HPLC). No significant correlations between plasma clozapine and norclozapine concentrations and clinical health improvement among our schizophrenic patients were found. However, a significant correlation was observed between clinical health improvement given by BPRS scores and norclozapine plasma concentration to daily clozapine dose ratio (NCZ/D). Despite the small sample size of our study, our findings suggest that the clozapine therapy response variations observed in our patients may be, in part, explained by the interindividual differences in plasma norclozapine concentration to clozapine dose ratio (NCZ/D). So the NCZ/D parameter could be used as a good indicator for adjusting the clozapine dose-adaptation strategy and consequently for improving the clinical psychopathological state of schizophrenia-treatment resistant patients.展开更多
文摘Bladder cancer is among the most frequently diagnosed cancer. Tobacco smoking exposures involving nitrosamines and aromatic amines are the main cause of bladder cancer. Although cigarette consumption has gradually decreased, an increased incidence of bladder cancer was registered among males Tunisian for the last two decades. A similar increased incidence of lung adenocarcinoma and bladder cancer was registered among Tunisian males. Epidemiological results suggest that changes in cigarette smoking may be the cause of the increased incidence of bladder cancer. The relationship between CYP1A2 enzyme activities, a key enzyme for activation of bladder carcinogens, and bladder cancer risk was investigated. Variations in CYP1 A2 activities measured in patients with bladder cancer and healthy smokers showed a signifycantly higher CYP1A2 metabolic activity in patient group. Changing in cigarette smoking habits associated to the variation in CYP1A2 activity seem to explain partly the increase incidence of bladder cancer observed in Tunisian male population.
文摘The present study investigated relationships between clozapine dose, clozapine and norclozapine plasma concentrations, and clinical responses to clozapine treatment in Tunisian schizophrenics. Fourteen schizophrenia-treatment resistant patients, recruited for this study, were treated with clozapine for 45 days. Patient health improvement was assessed before and after each cycle of two weeks of clozapine therapy, using the Brief Psychiatric Rating Scale (BPRS). Plasma clozapine and norclozapine concentrations were determined by high-performance liquid chromatography (HPLC). No significant correlations between plasma clozapine and norclozapine concentrations and clinical health improvement among our schizophrenic patients were found. However, a significant correlation was observed between clinical health improvement given by BPRS scores and norclozapine plasma concentration to daily clozapine dose ratio (NCZ/D). Despite the small sample size of our study, our findings suggest that the clozapine therapy response variations observed in our patients may be, in part, explained by the interindividual differences in plasma norclozapine concentration to clozapine dose ratio (NCZ/D). So the NCZ/D parameter could be used as a good indicator for adjusting the clozapine dose-adaptation strategy and consequently for improving the clinical psychopathological state of schizophrenia-treatment resistant patients.
