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Significance of Cu/Zn-Superoxide Dismutase Levels in Hemodialysis Patients: A Mini Review
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作者 Yuya Nakamura Masahiro Inagaki +8 位作者 sachiyo kenmotsu Shiho Yamadera Isao Ohsawa Hiromichi Gotoh Yoshikazu Goto Naoki Sato Tatsunori Oguchi Mayumi Tsuji Yuji Kiuchi 《Modern Research in Inflammation》 2017年第2期9-13,共5页
Cu/Zn-superoxide dismutase (Cu/Zn-SOD) is an enzyme that is ubiquitously present in the cytoplasm and causes dismutation of superoxide radicals, therefore Cu/Zn-SOD is primarily used as an antioxidant marker. Levels o... Cu/Zn-superoxide dismutase (Cu/Zn-SOD) is an enzyme that is ubiquitously present in the cytoplasm and causes dismutation of superoxide radicals, therefore Cu/Zn-SOD is primarily used as an antioxidant marker. Levels of Cu/Zn-SOD are higher in the serum of hemodialysis patients than in serum of healthy volunteers. The increase of serum Cu/Zn-SOD levels is related to the decrease of kidney function with aging and arteriosclerosis in hemodialysis patients. Moreover, infection, vascular puncture, and hemostasis may be related to the increase in serum Cu/Zn-SOD levels. As it is associated with numerous factors in hemodialysis patients, Cu/Zn-SOD may serve as a complex marker for arteriosclerosis, vascular, and inflammatory conditions. It is important to investigate various agents that decrease serum Cu/Zn-SOD levels to improve the life-span of hemodialysis patients. 展开更多
关键词 Cu/Zn-Superoxide DISMUTASE HEMODIALYSIS Complex MARKER
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