TO THE EDITOR Prion diseases are fatal and in curable n eurodegenerative diseases caused by a pathogenic form of prion protein(PrP^(Sc))derived from a cellular form of prion protein(PrP^(C)).Recent studies have report...TO THE EDITOR Prion diseases are fatal and in curable n eurodegenerative diseases caused by a pathogenic form of prion protein(PrP^(Sc))derived from a cellular form of prion protein(PrP^(C)).Recent studies have reported that aquaporin 4(AQP4)expression is dramatically upregulated in the brains of individuals with several different prion diseases.Since AQP4 is a key protein of the glymphatic system,which is the perivascular waste clearing system of the brain,and since altered expression of AQP4 has been observed in prion diseases,the glymphatic system may be associated with prion diseases.展开更多
基金This work was supported by a National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIT)(2021R1A2C1013213)This research was supported by the Basic Science Research Program through the National Research Foundation(NRF)of Korea funded by the Ministry of Education(2017R1A6A1A03015876)+1 种基金This work was supported by an NRF(National Research Foundation of Korea)Grant funded by the Korean Government(NRF-2019-Fostering Core Leaders of the Future Basic Science Program/Global Ph.D.Fellowship Program)SYW and YCK were supported by the BK21 Plus Program in the Department of Bioactive Material Sciences.
文摘TO THE EDITOR Prion diseases are fatal and in curable n eurodegenerative diseases caused by a pathogenic form of prion protein(PrP^(Sc))derived from a cellular form of prion protein(PrP^(C)).Recent studies have reported that aquaporin 4(AQP4)expression is dramatically upregulated in the brains of individuals with several different prion diseases.Since AQP4 is a key protein of the glymphatic system,which is the perivascular waste clearing system of the brain,and since altered expression of AQP4 has been observed in prion diseases,the glymphatic system may be associated with prion diseases.
