期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Hepatitis B Vaccine and Immunoglobulin: Key Concepts 被引量:4
1
作者 saibal das Kirubakaran Ramakrishnan +3 位作者 Sapan Kumar Behera Mahalakshmi Ganesapandian Alphienes Stanley Xavier Sandhiya Selvarajan 《Journal of Clinical and Translational Hepatology》 SCIE 2019年第2期165-171,共7页
Hepatitis B virus(HBV)immunization is safe and has been accepted worldwide as a routine practice.The target of such vaccination is to induce the immune response in the host,resulting in the prevention of replication o... Hepatitis B virus(HBV)immunization is safe and has been accepted worldwide as a routine practice.The target of such vaccination is to induce the immune response in the host,resulting in the prevention of replication of HBV.There are several immunological and clinical factors which determine the clinical efficacy and safety of the HBV vaccine.In this article we have highlighted the response of the host immune system to HBV vaccination(immunogenicity),efficacy,and safety of the vaccine,issues with booster dosing,paths of development(preclinical and clinical)of the HBV vaccine,novel and upcoming strategies for improvement of HBV vaccination,and the concept of therapeutic HBV vaccination.The different aspects and regulatory recommendations pertaining to HBV vaccine development are also discussed.The new strategies for improvement of HBV vaccination include pre-S1 and pre-S2 portions of the HBV surface antigen,increasing the antigen dose,accelerated vaccination schedules,alternative vaccination route,use of adjuvants like immunostimulatory DNA sequences,etc.Therapeutic vaccination is being explored for initiation of a multifunctional and multispecific T cell response against the major HBV antigens and also effective activation of humoral immunity for viral control. 展开更多
关键词 ANTIBODY DEVELOPMENT Immune response IMMUNOGLOBULIN VACCINE
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部