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Percutaneous kyphoplasty in the treatment of Kümmell disease in lumbar scoliosis:A case report
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作者 saijilafu Jia-Wen Zhou +2 位作者 Gen-Lin Wang Ke-Hong Sun Ji-Le Xie 《World Journal of Clinical Cases》 SCIE 2024年第17期3123-3129,共7页
BACKGROUND Due to mechanical imbalance in the spine,elderly scoliosis patients tend to develop vertebral fracture nonunion,i.e.,Kümmell disease,when osteoporotic vertebral compression fractures occur.However,acco... BACKGROUND Due to mechanical imbalance in the spine,elderly scoliosis patients tend to develop vertebral fracture nonunion,i.e.,Kümmell disease,when osteoporotic vertebral compression fractures occur.However,accompanying vertebral rotational deformities make surgical procedures challenging risky.Such patients are usually compelled to undergo conservative treatment and there are very few reports on minimally invasive surgeries for them.We first-time report a patient with Kümmell disease and lumbar scoliosis treated with percutaneous kyphoplasty(PKP)under O-arm guidance.CASE SUMMARY An 89-year-old female was admitted to the hospital due to delayed low back pain after a fall.She was diagnosed with Kümmell disease based on physical and radiologic examinations.The patient experienced severe scoliosis and subsequently underwent O-arm-guided kyphoplasty,resulting in a significant alleviation of low back pain.CONCLUSION PKP has good efficacy in treating Kümmell disease.However,surgical risks are elevated in scoliosis patients with Kümmell disease due to the abnormal anatomical structure of the spine.O-arm assisted operations play a crucial role in decreasing surgical risks. 展开更多
关键词 Kümmell disease Vertebral compression fracture SCOLIOSIS KYPHOPLASTY Case report
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Individualized vaginal applicator for stage IIb primary vaginal adenocarcinoma:A case report
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作者 saijilafu Yan-Jun Gu +2 位作者 Ai-Wu Huang Chang-Fen Xu Li-Wen Qian 《World Journal of Clinical Oncology》 2024年第8期1102-1109,共8页
BACKGROUND Primary vaginal cancer is rare and most vaginal tumors are metastatic,often arising from adjacent gynecologic structures.Primary vaginal cancers are also more common among postmenopausal women and most of t... BACKGROUND Primary vaginal cancer is rare and most vaginal tumors are metastatic,often arising from adjacent gynecologic structures.Primary vaginal cancers are also more common among postmenopausal women and most of these are squamous cell carcinomas,with adenocarcinomas being relatively rare.Vaginal bleeding is the most common clinical manifestation of vaginal adenocarcinoma.About 70%of vaginal adenocarcinomas are stage I lesions at the time of diagnosis,for which radical surgery is recommended.However,more advanced vaginal cancers are not amenable to radical surgical treatment and have poor clinical outcomes.Optimal treatments modes are still being explored.Here,we report a rare case of stage IIb primary vaginal adenocarcinoma for which an individually designed vaginal applicator for after-loading radiotherapy was used to achieve good tumor control.CASE SUMMARY A 62-year-old woman presented to our clinic after 3 months of abnormal postmenopausal vaginal bleeding.Gynecological examination,computed tomography(CT),and positron emission tomography-CT showed a large mass(about 5 cm)on the anterior vaginal wall.Colposcopy biopsy confirmed adenocarcinoma of vaginal origin.After three cycles of carboplatin plus paclitaxel chemotherapy,the lesion partially shrunk.The patient then received external irradiation of 45 gray(gy)in 25 fractions,which further reduced the vaginal lesion,followed by after-loading radiotherapy of 30 gy in 5 fractions with an individually designed vaginal applicator.Three months later,magnetic resonance imaging showed a slight thickening CONCLUSION Primary vaginal adenocarcinoma is rare,and prognosis is poor in most vaginal cancers of locally advanced stages,which cannot be treated with radical surgery.Better tumor control can be achieved with an individualized vaginal applicator that allows administration of a higher radical dose to the tumor area while protecting normal tissues. 展开更多
关键词 Primary vaginal adenocarcinoma After-loading radiotherapy Vaginal applicator Tumor control Case report
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敲减骨桥蛋白的膝关节滑膜细胞转录组和蛋白质组定量分析 被引量:2
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作者 徐人杰 钟桥 +5 位作者 刘宇博 虞宵 颜勇卿 赛吉拉夫 杨惠林 陈广祥 《中国组织工程研究》 CAS 北大核心 2022年第11期1680-1685,共6页
背景:骨关节炎患者关节软骨和关节液中骨桥蛋白mRNA水平及蛋白表达均较正常人明显增高,但是骨桥蛋白在膝骨关节炎发展进程中的作用及其具体机制在既往文献中尚未阐明。目的:探讨膝骨关节炎患者膝关节滑膜细胞中骨桥蛋白水平及其与骨关... 背景:骨关节炎患者关节软骨和关节液中骨桥蛋白mRNA水平及蛋白表达均较正常人明显增高,但是骨桥蛋白在膝骨关节炎发展进程中的作用及其具体机制在既往文献中尚未阐明。目的:探讨膝骨关节炎患者膝关节滑膜细胞中骨桥蛋白水平及其与骨关节炎严重程度的关系,并通过转录组和蛋白质组测序,进一步阐述其影响骨关节炎进展的机制。方法:选取2019年诊治的42例原发性膝骨关节炎患者,根据胫股关节受累情况,分为单间室骨关节炎组和双间室骨关节炎组。获取滑膜标本及关节液标本,PCR法检测滑膜标本中骨桥蛋白基因在细胞中的表达丰度,ELISA法检测关节液标本中骨桥蛋白水平。应用酶消化法获取培养人膝骨关节炎滑膜成纤维样细胞,用骨桥蛋白siRNA干预24 h后,对样品进行转录组和蛋白质组检测。结果与结论:(1)与单间室骨关节炎组相比,双间室骨关节炎组关节滑膜及关节液中骨桥蛋白均升高,差异有显著性意义(P<0.05);(2)体外培养人膝骨关节炎滑膜成纤维样细胞,通过siRNA敲减骨桥蛋白后,转录组与蛋白质组定量研究分别鉴定了14662个转录本和3608个蛋白,其中5种蛋白的转录组与蛋白质组分析结果显示同步下降,2种蛋白的转录组与蛋白质组分析结果显示同步上升;(3)结果表明,骨桥蛋白对骨关节炎产生不利影响,其机制可能是通过促炎作用和胰岛素样生长因子结合蛋白3对软骨的负面作用。 展开更多
关键词 膝关节 骨关节炎 骨桥蛋白 滑膜细胞 转录组 蛋白质组 机制
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硫化氢缓释供体ADT-OH对神经前体细胞增殖的调控 被引量:1
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作者 周立宇 马艳霞 +3 位作者 齐士斌 赛吉拉夫 韦善文 倪莉 《中国组织工程研究》 CAS 北大核心 2021年第1期96-100,共5页
背景:研究人员认为,硫化氢作为一种重要的细胞保护分子,通过人为调控内源性硫化氢生物合成或使用硫化氢供体体外给药可能成为新的疾病治疗方式,用来恢复病变细胞或器官系统的生理功能。ADT-OH是硫化氢的一种缓释供体,它能够提高谷氨酸... 背景:研究人员认为,硫化氢作为一种重要的细胞保护分子,通过人为调控内源性硫化氢生物合成或使用硫化氢供体体外给药可能成为新的疾病治疗方式,用来恢复病变细胞或器官系统的生理功能。ADT-OH是硫化氢的一种缓释供体,它能够提高谷氨酸诱导的损伤海马神经细胞的生存率,但是对大脑皮质神经前体细胞增殖的影响尚不清楚。目的:探究ADT-OH对胚胎期大脑皮质神经前体细胞增殖的影响。方法:分离E14.5 d胚胎小鼠大脑皮质心室带和脑室管膜下区神经前体细胞,将1只胎鼠的神经前体细胞接种于1个孔中(24孔板),培养基中加入100μmol/L ADT-OH药物进行培养,3 d后统计每孔中神经球的大小和数目,对培养的神经前体细胞进行BrdU标记检测细胞增殖率,用增殖细胞的特异性抗体Ki67对细胞进行免疫荧光染色进一步验证细胞增殖情况,最后采用Western blot检测增殖相关基因cyclin D1的表达。结果与结论:ADT-OH可促进神经球的形成,提高神经前体细胞的增殖率,同时神经前体细胞中增殖相关基因cyclin D1的表达上调。由以上数据可知,ADT-OH促进神经前体细胞的增殖可能是通过调控cyclin D1的表达来完成。 展开更多
关键词 硫化氢 ADT-OH 神经前体细胞 细胞增殖 神经球 BRDU Ki67 免疫荧光染色 cyclin D1
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纳米β磷酸三钙/水凝胶复合材料促进骨再生的实验研究
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作者 徐人杰 马进进 +6 位作者 周晓强 虞宵 颜勇卿 杨志杰 杨惠林 赛吉拉夫 陈广祥 《中国骨科临床与基础研究杂志》 2021年第3期108-115,共8页
目的观察纳米β磷酸三钙(TCP)/水凝胶复合材料对骨再生的促进作用。方法制作纳米β-TCP/甲基丙烯酸酰化明胶(GelMA)水凝胶复合材料。根据培养基的不同,分为空白对照组、GelMA组和纳米β-TCP/GelMA组,将大鼠骨髓间充质干细胞(BMSCs)与上... 目的观察纳米β磷酸三钙(TCP)/水凝胶复合材料对骨再生的促进作用。方法制作纳米β-TCP/甲基丙烯酸酰化明胶(GelMA)水凝胶复合材料。根据培养基的不同,分为空白对照组、GelMA组和纳米β-TCP/GelMA组,将大鼠骨髓间充质干细胞(BMSCs)与上述培养基共同培养。通过电镜观察、细胞增殖实验、碱性磷酸酶(ALP)染色,了解纳米β-TCP/GelMA复合材料的生物相容性及体外骨诱导活性。制作大鼠颅骨缺损模型,根据植入材料的不同,分为空白对照组、GelMA组和纳米β-TCP/GelMA组,术后4、8周取颅骨标本,通过Micro-CT扫描计算骨量分数和骨密度,对新骨形成情况进行组织学观察。结果大鼠BMSCs在材料表面培养48 h,扫描电镜观察发现其在GelMA组和纳米β-TCP/GelMA组表面良好贴附及铺展;细胞与材料共培养1、3、5 d,BMSCs数量随时间推移不断增加,3、5 d时纳米β-TCP/GelMA组OD值最高(P<0.05),7 d时与GelMA组相比,纳米β-TCP/GelMA组ALP表达明显增强。大鼠颅骨缺损区Micro-CT检查显示,纳米β-TCP/GelMA组骨量分数和骨密度高于空白对照组和GelMA组,差异具有统计学意义(P<0.05);组织学观察结果显示,与空白对照组、GelMA组相比,纳米β-TCP/GelMA组新生骨更丰富。结论纳米β-TCP/水凝胶复合材料具有良好的生物相容性,体外可促进大鼠BMSCs增殖和成骨分化,在大鼠颅骨缺损模型中具有良好的促进骨再生能力。 展开更多
关键词 纳米复合物 磷酸钙类 水凝胶 生物相容性材料 骨代用品 骨髓细胞 干细胞 细胞 培养的 颅骨缺损 大鼠 骨生成 骨再生
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子宫内电穿孔转染胎鼠脑室管膜下区神经干细胞的条件优化 被引量:1
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作者 邹明明 倪莉 +4 位作者 周立宇 李迪 赛吉拉夫 韦善文 张鹏飞 《中国组织工程研究》 CAS 北大核心 2022年第30期4879-4883,共5页
背景:神经干细胞是一群可以自我增殖并具有多向分化潜能的细胞。子宫内电穿孔转染可将RNA或质粒瞬时转入活体小鼠神经干细胞内对目的基因进行干扰或过表达,是目前活体研究大脑皮质发育的最直接可靠的研究方法。目的:以胚胎小鼠脑室管膜... 背景:神经干细胞是一群可以自我增殖并具有多向分化潜能的细胞。子宫内电穿孔转染可将RNA或质粒瞬时转入活体小鼠神经干细胞内对目的基因进行干扰或过表达,是目前活体研究大脑皮质发育的最直接可靠的研究方法。目的:以胚胎小鼠脑室管膜下区的神经干细胞为目标,以增强型绿色荧光蛋白作为报告基因,优化子宫内电穿孔转染的条件,为研究大脑皮质的发育提供更加有效的方法。方法:将成年ICR小鼠以1只雄鼠和3只雌鼠的比例进行交配,晚上8点将小鼠合笼,第2天早晨8点查验雌鼠阴栓,将有阴栓的雌鼠计为怀孕0.5 d。待怀孕14 d(E14)时腹腔注射Ketamin(120 mg/kg)和Xylazine(10 mg/kg)麻醉孕鼠,剃掉孕鼠腹部毛发,打开腹腔,不剪开孕鼠子宫,用ECM803电穿孔转染仪和BTX电极在不同的电压下将pEx-4-eGFP质粒在电场的作用下瞬时转入胎鼠脑室管膜下区的神经干细胞内。转染3 d后取出转染小鼠脑组织进行冰冻切片,观察增强型绿色荧光蛋白在大脑皮质上的表达,统计绿色荧光蛋白阳性细胞数来评估转染效率。结果与结论:①电转电压在38,40,42,45 V时小鼠存活及转染效果不同,38 V电压对胎鼠的致死性较小,但是转染效率较低,在42 V电压下电转的小鼠可存活,且电转的脑组织中绿色荧光蛋白荧光强度高于40 V电压,但是45 V电压对小鼠的致死性较大。因此,42 V电压是一个较好的电转条件。②在电压42 V条件下,脉冲数由5个改为8个后绿色荧光蛋白阳性细胞更多,荧光更亮。③改良后的电转条件对转染成功的细胞生长无影响。 展开更多
关键词 子宫 电穿孔 转染 神经干细胞 电压 脉冲 转染效率
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Decoding epigenetic codes: new frontiers in exploring recovery from spinal cord injury 被引量:3
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作者 Bo-Yin Zhang Peng-Yu Chang +2 位作者 Qing-San Zhu Yu-Hang Zhu saijilafu 《Neural Regeneration Research》 SCIE CAS CSCD 2020年第9期1613-1622,共10页
Spinal cord injury that results in severe neurological disability is often incurable.The poor clinical outcome of spinal cord injury is mainly caused by the failure to reconstruct the injured neural circuits.Several i... Spinal cord injury that results in severe neurological disability is often incurable.The poor clinical outcome of spinal cord injury is mainly caused by the failure to reconstruct the injured neural circuits.Several intrinsic and extrinsic determinants contribute to this inability to reconnect.Epigenetic regulation acts as the driving force for multiple pathological and physiological processes in the central nervous system by modulating the expression of certain critical genes.Recent studies have demonstrated that post-SCI alteration of epigenetic landmarks is strongly associated with axon regeneration,glial activation and neurogenesis.These findings not only establish a theoretical foundation for further exploration of spinal cord injury,but also provide new avenues for the clinical treatment of spinal cord injury.This review focuses on the epigenetic regulation in axon regeneration and secondary spinal cord injury.Together,these discoveries are a selection of epigenetic-based prognosis biomarkers and attractive therapeutic targets in the treatment of spinal cord injury. 展开更多
关键词 axon regeneration epigenetic biomarkers epigenetic modification HISTONE microRNA prognosis secondary injury spinal cord injury
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Glycogen synthase kinase 3: a crucial regulator of axotomy-induced axon regeneration 被引量:2
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作者 Jinlian Liu Qing Zhou +2 位作者 Chaoqun Liu Chunfeng Liu saijilafu 《Neural Regeneration Research》 SCIE CAS CSCD 2020年第5期859-860,共2页
Following nerve injury,axonal disconnection in neurons usually results in persistent functional deficits,such as paralysis.However,axons in the adult mammalian central nervous system (CNS) have very limited regenerati... Following nerve injury,axonal disconnection in neurons usually results in persistent functional deficits,such as paralysis.However,axons in the adult mammalian central nervous system (CNS) have very limited regenerative ability.Understanding the molecular mechanism of controlling axon regeneration can provide idea for the design of effective therapeutic interventions for CNS injury,such as spinal cord injuries.Efficient axonal regeneration is achieved via gene expression in the neuronal soma,axonal transport of raw materials along the shaft,and membrane and cytoskeleton assembly at the nerve growth cone.Each process is delicately regulated by spatial-temporal controlled signaling pathways that target distinct effectors.Gene expression in the neuronal soma,especially of transcription factors,is often activated immediately following nerve injury.Injury signals at distal axons are interpreted and transmitted back to the soma,initiating a stream of gene expression events which positively regulate subsequent axonal regeneration.Over the past few decades,extensive studies have identified many regeneration-associated genes,including CREB,nuclear factor of activated T-cells,protein 53,Sprr1a,c-Jun,Smad1,activating transcription factor 3,signal transducer and activator of transcription 3,SRF,Sox11,and Kruppel-like factors.However,we know far less about how the coordinated expression of these regeneration-associated genes is regulated during axonal regeneration.Indeed,it is possible that they are regulated by a single common upstream regulator.If so,identification of this upstream regulator will provide us with an invaluable target for the development of more effective treatments for traumatic nerve injuries.Adult dorsal root ganglion (DRG) neurons represent a favorable medium in which to study the molecular mechanisms controlling intrinsic neuronal axon growth ability.Axotomy of the peripheral branch of a DRG neuron,known as a “conditioning lesion”,has been well-documented to greatly accelerate axonal growth both in vivo and in vitro,by enhancing the neuronal intrinsic growth potential.Enhancement of the growth state is thought to be mediated by a transcription-dependent axonal growth system that controls the expression of a number of regeneration-associated genes. 展开更多
关键词 GENE expression SPINAL CORD CENTRAL nervous system
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Deletion of Krüppel-like factor-4 promotes axonal regeneration in mammals 被引量:1
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作者 Jin-Hui Xu Xu-Zhen Qin +7 位作者 Hao-Nan Zhang Yan-Xia Ma Shi-Bin Qi Hong-Cheng Zhang Jin-Jin Ma Xin-Ya Fu Ji-Le Xie saijilafu 《Neural Regeneration Research》 SCIE CAS CSCD 2021年第1期166-171,共6页
Axonal regeneration plays an important role in functional recovery after nervous system damage.However,after axonal injury in mammals,regeneration is often poor.The deletion of Krüppel-like factor-4(Klf4)has been... Axonal regeneration plays an important role in functional recovery after nervous system damage.However,after axonal injury in mammals,regeneration is often poor.The deletion of Krüppel-like factor-4(Klf4)has been shown to promote axonal regeneration in retinal ganglion cells.However,the effects of Klf4 deletion on the corticospinal tract and peripheral nervous system are unknown.In this study,using a mouse model of sciatic nerve injury,we show that the expression of Klf4 in dorsal root ganglion sensory neurons was significantly reduced after peripheral axotomy,suggesting that the regeneration of the sciatic nerve is associated with Klf4.In vitro,dorsal root ganglion sensory neurons with Klf4 knockout exhibited significantly enhanced axonal regeneration.Furthermore,the regeneration of the sciatic nerve was enhanced in vivo following Klf4 knockout.Finally,AAV-Cre virus was used to knockout the Klf4 gene in the cortex.The deletion of Klf4 enhanced regeneration of the corticospinal tract in mice with spinal cord injury.Together,our findings suggest that regulating KLF4 activity in neurons is a potential strategy for promoting axonal regeneration and functional recovery after nervous system injury.This study was approved by the Animal Ethics Committee at Soochow University,China(approval No.SUDA20200316A01). 展开更多
关键词 axonal regeneration corticospinal tract dorsal root ganglion KLF4 peripheral nervous system sciatic nerve crush sensorimotor cortex spinal cord crushl
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CaMK Ⅱ-Smad1促进外周神经的轴突再生
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作者 王丰 周立宇 +3 位作者 赛吉拉夫 齐士斌 马艳霞 韦善文 《中国组织工程研究》 CAS 北大核心 2021年第7期1064-1068,共5页
背景:哺乳动物中枢神经系统损伤后轴突不能再生,主要是由于损伤处抑制性微环境和自身再生能力减弱导致的。研究发现,外周神经系统损伤后具有一定的再生能力,因此通过研究促进外周神经系统再生的基因来探索中枢神经系统修复的方法。CaMK... 背景:哺乳动物中枢神经系统损伤后轴突不能再生,主要是由于损伤处抑制性微环境和自身再生能力减弱导致的。研究发现,外周神经系统损伤后具有一定的再生能力,因此通过研究促进外周神经系统再生的基因来探索中枢神经系统修复的方法。CaMKⅡ作为神经元重要的蛋白激酶家族之一,它的上调能够提高神经元再生能力;同样在成年小鼠中Smad1蛋白的急性耗竭也会阻碍轴突在体内的再生。这些基因都可以直接或者间接调控神经元轴突再生,但是具体如何调控神经再生,目前还不够清楚。目的:采用腹腔注射CaMKⅡ抑制剂与激活剂的方法研究CaMKⅡ-Smad1信号通路对背根神经节神经元轴突再生的影响,探究CaMKⅡ和Smad1调节背根神经节神经元轴突再生的作用机制。方法:取40只ICR小鼠进行实验,随机分成4组:KN93对照组、KN93实验组、CdCl2对照组、CdCl2实验组,连续7 d腹腔注射CaMKⅡ抑制剂KN93或CaMKⅡ激活剂CdCl2之后取背根神经节组织进行体外培养,3 d后统计分析背根神经节神经元轴突再生的长度,Western blot实验检测背根神经节神经元中p-Smad1蛋白表达。结果与结论:①与KN93对照组比较,KN93实验组背根神经节神经元轴突再生能力受到抑制,p-Smad1蛋白表达下降,差异有显著性意义;②与CdCl2对照组比较,CdCl2实验组背根神经节神经元轴突再生能力得到促进,p-Smad1蛋白表达上升,差异有显著性意义;③结果表明CaMKⅡ-Smad1信号通路对背根神经节神经元轴突再生有调控作用。 展开更多
关键词 背根神经节 神经元 CaMKⅡ SMAD1 轴突再生 腹腔注射 细胞培养
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Multiple stress fractures of unilateral femur:A case report
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作者 Mao-Ting Tang Chun-Feng Liu +2 位作者 Jin-Lian Liu saijilafu Zhen Wang 《World Journal of Clinical Cases》 SCIE 2022年第13期4280-4287,共8页
BACKGROUND Stress fractures of the femoral neck are not common in clinical practice,and simultaneous stress fractures of the femoral neck and proximal femur of the unilateral femur are even more rare.We introduce a ca... BACKGROUND Stress fractures of the femoral neck are not common in clinical practice,and simultaneous stress fractures of the femoral neck and proximal femur of the unilateral femur are even more rare.We introduce a case of this type of fracture that was treated in our department,analyze the causes,and review similar stress fractures reported in the literature to provide references for the diagnosis and treatment of such conditions.CASE SUMMARY A 62-year-old female,with a free medical history,was admitted to the hospital mainly due to pain in the right hip and worsening pain in the right thigh.The patient had no obvious history of trauma.X-ray and computed tomography showed fracture of the femoral neck and proximal femur.The patient had undergone surgery 1 year prior to address a fracture of the left proximal femur that had occurred in a traffic accident.Our first consideration was stress fracture of the femoral neck;however,simultaneous stress fractures of the femoral neck and proximal femur of the unilateral femur were seen.The femoral neck stress fracture was a tension fracture,with obvious displacement and varus deformity of the hip.Considering that the patient was an elderly female,we performed total hip arthroplasty.Follow-up X-rays showed that the stress fracture of the proximal femur had mostly healed after 3 mo.CONCLUSION Muscle fatigue and hip varus deformity provide an anatomical basis for the occurrence of femoral neck stress fractures. 展开更多
关键词 Femoral neck fracture Femoral fracture Stress fracture Fatigue fracture Hip pain Case report
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Heel pain caused by os subcalcis:A case report
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作者 saijilafu Suo-Yuan Li +5 位作者 Xiao Yu Zhi-Qiang Li Guang Yang Jing-Huan Lv Guang-Xiang Chen Ren-Jie Xu 《World Journal of Clinical Cases》 SCIE 2022年第16期5373-5379,共7页
BACKGROUND The accessory bones are common bone variations around the feet and ankles,which usually originate from nonunion of the secondary ossification center adjacent to the main bone mass,and most of them remain as... BACKGROUND The accessory bones are common bone variations around the feet and ankles,which usually originate from nonunion of the secondary ossification center adjacent to the main bone mass,and most of them remain asymptomatic.Os subcalcis is an accessory bone at the plantar aspect of the calcaneus,which is located just posterior to the insertion of the plantar fascia.Focal bone formation at the calcaneal plantar pole with heel pain has rarely been reported.CASE SUMMARY A 55-year-old man presented to our clinic with left plantar heel pain and a progressive swelling for 8 years.X-ray,computer tomography and magnetic resonance imaging showed a large os subcalcison the plantar side of the calcaneus,located at the insertion of the plantar fascia.He underwent surgical excision of the lesion.Microscopically the bony trabeculae were intermingled with fat and covered with cartilage.CONCLUSION This is a rare case with accessory os subcalcis leading to heel pain.It highlights the awareness of os subcalcis and helps avoid future misdiagnosis of heel pain. 展开更多
关键词 Heel pain Accessory ossicle CALCANEUS Os subcalcis Case report
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Signaling pathways that regulate axon regeneration 被引量:7
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作者 saijilafu Bo-Yin Zhang Feng-Quan Zhou 《Neuroscience Bulletin》 SCIE CAS CSCD 2013年第4期411-420,共10页
Neurons in the mammalian central nervous system (CNS) cannot regenerate axons after injury. In contrast, neurons in the mammalian peripheral nervous system and in some non-mammalian models, such as C. elegans and Dr... Neurons in the mammalian central nervous system (CNS) cannot regenerate axons after injury. In contrast, neurons in the mammalian peripheral nervous system and in some non-mammalian models, such as C. elegans and Drosophila, are able to regrow axons. Understanding the molecular mechanisms by which these neurons support axon regeneration will help us find ways to enhance mammalian CNS axon regeneration. Here, recent studies in which signaling pathways regulating naturally-occurring axon regeneration that have been identified are reviewed, focusing on how these pathways control gene expression and growth-cone function during axon regeneration. 展开更多
关键词 axon regeneration axonal growth signal transduction
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