Objective(s): To investigate if testosterone levels are higher in patients with preeclampsia compared to normotensive pregnant patients. Study design: The levels of serum total and free testosterone, dehydroepiandrost...Objective(s): To investigate if testosterone levels are higher in patients with preeclampsia compared to normotensive pregnant patients. Study design: The levels of serum total and free testosterone, dehydroepiandrosterone sulfate, androstenedione and sex hormone binding globulin were estimated in 28 patients during the third trimester of pregnancy with established preeclampsia and 25 normotensive women. Results: No statistically significant diffe- rences were noted between the two groups regarding the maternal age, gestational age, body mass index(BMI) haematocrit and neonatal sex. The mean±S.D. total testosterone and free testosterone levels were significantly higher(p< 0.01) in the group with preeclapsia compared to the control group. The values of DHEA-S, androstenedione and sex hormone binding globulin were lower in the group with preeclampsia but the difference did not reach statistical significance. Conclusion(s): The levels of total and free testosterone appear to be higher in patients with preeclampsia compared to normotensive pregnant women during the third trimester of pregnancy. This difference could indicate an involvement of testosterone in the pathophysiology of preeclampsia and stimulates research in the potential role of antiandrogens in the management of preeclampsia.展开更多
Insulin levels,insulin resistance,and leptin levels were evaluated in 47women who developed o varian hyperstim-ulation syndrome (OHSS)after participation in assisted reproduction technologies program s and in 47matche...Insulin levels,insulin resistance,and leptin levels were evaluated in 47women who developed o varian hyperstim-ulation syndrome (OHSS)after participation in assisted reproduction technologies program s and in 47matched controls who did not develop such a complication.Analysis of the results in relation to underly ing polycystic ovarian syndrome and hyperinsulinemia reve aled no association of insulin levels,insulin resistance,and leptin levels with the development of OHSS.展开更多
文摘Objective(s): To investigate if testosterone levels are higher in patients with preeclampsia compared to normotensive pregnant patients. Study design: The levels of serum total and free testosterone, dehydroepiandrosterone sulfate, androstenedione and sex hormone binding globulin were estimated in 28 patients during the third trimester of pregnancy with established preeclampsia and 25 normotensive women. Results: No statistically significant diffe- rences were noted between the two groups regarding the maternal age, gestational age, body mass index(BMI) haematocrit and neonatal sex. The mean±S.D. total testosterone and free testosterone levels were significantly higher(p< 0.01) in the group with preeclapsia compared to the control group. The values of DHEA-S, androstenedione and sex hormone binding globulin were lower in the group with preeclampsia but the difference did not reach statistical significance. Conclusion(s): The levels of total and free testosterone appear to be higher in patients with preeclampsia compared to normotensive pregnant women during the third trimester of pregnancy. This difference could indicate an involvement of testosterone in the pathophysiology of preeclampsia and stimulates research in the potential role of antiandrogens in the management of preeclampsia.
文摘Insulin levels,insulin resistance,and leptin levels were evaluated in 47women who developed o varian hyperstim-ulation syndrome (OHSS)after participation in assisted reproduction technologies program s and in 47matched controls who did not develop such a complication.Analysis of the results in relation to underly ing polycystic ovarian syndrome and hyperinsulinemia reve aled no association of insulin levels,insulin resistance,and leptin levels with the development of OHSS.
