期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Development and Validation of a High Performance Thin Layer Chromatographic Method for Quantitative Analysis of Saxagliptin
1
作者 salvala srividya Ettireddy Swetha Ciddi Veeresham 《American Journal of Analytical Chemistry》 2015年第10期797-806,共10页
A simple, specific, accurate and precise high performance thin layer chromatographic method (HPTLC) was developed for the quantitative analysis of Saxagliptin in active pharmaceutical ingredients (APIs) and pharmaceut... A simple, specific, accurate and precise high performance thin layer chromatographic method (HPTLC) was developed for the quantitative analysis of Saxagliptin in active pharmaceutical ingredients (APIs) and pharmaceutical dosage forms. The method was achieved using silica gel aluminum plate 60 F254 (10 × 10 cm) as stationary phase and Methanol:Chloroform (6:4 v/v) as mobile phase. The developed plate was scanned densitometrically using UV 222 nm wavelength. The Rf value of Saxagliptin was found to be 0.50 ± 0.02. The developed method was validated according to ICH guidelines. Limit of detection (LOD) and limit of quantification (LOQ) of Saxagliptin by this method were found as 7.96 ng/spot and 26.54 ng/spot, respectively. The method was found to be sensitive, specific, linear, accurate, precise and robust for the quantitative analysis of Saxagliptin in both APIs and marketed tablet formulation. 展开更多
关键词 HPTLC SAXAGLIPTIN QUANTITATIVE Analysis Stress Induced DEGRADATION VALIDATION API
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部