Spectroscopic Investigations for the Six New Synthesized Complexes of Fluoroquinolones and Quinolones Drugs With Nickel(Ⅱ) Metal Ion:Infrared and Electronic Spectroscopy

Quinolone has a broad spectrum of synthetic antibiotics with a strong therapeutic effect and quinolone is a term used for chemical treatments used to treat a powerful bacteria.Quinolones are divided into 4 generations according to the bacterial spectrum,the majority of quinolones used clinically belong to the sub fluoroquinolones group,which has a fluorine atom linked to the central ring system,usually on its carbon atom 6 or 7.Herein in this article,six new nickel(Ⅱ)complexes(Ⅰ—Ⅵ)have been synthesized in aqueous alkaline media at pH ranged 8-9,the chemical reactions take place between levofloxacin(HLEV),lomefloxacin(HLOM),nalidixic acid(HNLA),oxolonic acid(HOXO),pipemidic acid(HPIP),and pefloxacin mesylate(HPEF)with nickel(Ⅱ)nitrate hexahydrate.The microanalytical(percentage of carbon,hydrogen and nitrogen),molar conductance(Λm),Infrared(FTIR)spectra,electronic(UV-Vis)spectra,and effective magnetic moment instrumentals were used to identify the suggested structures and their surface morphology.According the analytical and spectroscopic analyses,the stoichiometry between nickel(Ⅱ)metal ion and drug ligands was found to be 1∶2 with general formula as[Ni(L)_(2)(H_(2)O)_(2)]·x H_(2)O(L=LEV(Ⅰ),LOM(Ⅱ),NAL(Ⅲ),OXO(Ⅳ),PIP(V),and PEF(Ⅵ);x=2 or 4).By the comparison between FTIR spectra of quinolone drugs and their complexes,it can be deduced that all the drug ligands act as a bidentate chelates through oxygen atoms of pyridine ring and carboxylate group.The electronic configuration of all synthesized nickel(Ⅱ)complexes were octahedral geometry which confirmed based on the values of magnetic susceptibility and the electronic transition bands.

Spectroscopic Characterizations of Metal-Complexes of 4-Hydroxybenzoic Acid With the Ni(Ⅱ),Mn(Ⅱ),and Cu(Ⅱ)Ions

One of the phenolic acids is 4-hydroxybenzoic acid(HBA)which takes the form of a white crystalline solid with a molecular formula of C 7H 6O 3,a melting point of 214.5℃and a molecular weight of 138.12 g·mol^(-1).It soluble in polar organic solvents like acetone and alcohols,and slightly soluble in chloroform and water.The reactions between the metal ions and the HBA were carried out under specific conditions like(molar reaction was 2∶2(ligand to metal),reaction temperature was 60℃,media was neutral(pH 7),and solvent was H 2O∶MeOH(1∶1).Under these conditions,the HBA was deprotonated to form(HOC_(6)H_(4)CO^(2);L^(-)).The ligand L-was coordinated to the metal ions forming the metal complexation.The reaction of 4-hydroxybenzoic acid(HOC 6H 4CO 2H;HL)with the Ni(Ⅱ),Mn(Ⅱ)and Cu(Ⅱ)ions afford metal-complexes with gross formula of[Ni_(2)L_(2)(NO_(3))_(2)(H_(2)O)_(4)],[Mn_(2)L_(2)(NO_(3))_(2)(H_(2)O)_(4)]and[Cu_(2)L_(2)(NO_(3))_(2)(H_(2)O)_(4)],respectively.These complexes were characterized by elemental analysis(CHN),magnetic susceptibility,UV-Vis spectra,infrared(IR),and X-ray powder diffraction(XRD)techniques.The complexes of HBA are insoluble in common solvents and hence molar conductance could not be measured,but this very insolubility indicates that the complexes are neutral.Data has demonstrated that the ligand(L^(-))was coordinated to the metal ion by bidentate bridging carboxylate group(COO^(-)),with an octahedral geometry.Thus,HBA is expected to act as bidentate uninegative ions and the coordination number of the metal ions is six.XRD results showed that the complexes possess uniform and organized microstructures in the nanometer range with a main diameter in the range of 11~28 nm.