Since the association between nephrogenic systemic fibrosis(NSF) and gadolinium contrast agents(Gd-CAs) was suggested in 2006,several experimental studies have been published to elucidate the role of these agents in t...Since the association between nephrogenic systemic fibrosis(NSF) and gadolinium contrast agents(Gd-CAs) was suggested in 2006,several experimental studies have been published to elucidate the role of these agents in the pathogenesis of NSF.Low stability Gd-CAs have a stimulant effect on human skin and fibroblasts in culture and modulate the production of collagen by these cells.Low stability agents have also induced NSFlike skin changes in a rat model with normal renal function after multiple repeat administrations.The role of the 5/6 subtotal nephrectomy rat model in investigating NSF remains under evaluation.展开更多
文摘Since the association between nephrogenic systemic fibrosis(NSF) and gadolinium contrast agents(Gd-CAs) was suggested in 2006,several experimental studies have been published to elucidate the role of these agents in the pathogenesis of NSF.Low stability Gd-CAs have a stimulant effect on human skin and fibroblasts in culture and modulate the production of collagen by these cells.Low stability agents have also induced NSFlike skin changes in a rat model with normal renal function after multiple repeat administrations.The role of the 5/6 subtotal nephrectomy rat model in investigating NSF remains under evaluation.
